No association of the dopamine DRD4 receptor (DRD4) gene polymorphism with attention deficit hyperactivity disorder (ADHD) in the Irish population

American Journal of Medical Genetics - Neuropsychiatric Genetics

Volumn 96, Issue 3, 2000, Pages 268-272

  Hawi, Ziarih ^a   McCarron, Mary ^a   Kirley, Aiveen ^a   Daly, Grainne ^a   Fitzgerald, Michael ^a   Gill, Michael ^a  

^a TRINITY COLLEGE DUBLIN   (Ireland)

Author keywords

Association; Attention deficit hyperactivity disorder (ADHD); Dopamine DRD4; Haplotype based haplotype relative risk (HHRR)

Indexed keywords

DOPAMINE 4 RECEPTOR;

ADOLESCENT; ADULT; ARTICLE; ATTENTION DEFICIT DISORDER; CHILD; CHROMOSOME 11P; GENE FREQUENCY; GENE MAPPING; GENETIC ASSOCIATION; GENETIC POLYMORPHISM; GENETIC PREDISPOSITION; HUMAN; IRELAND; MAJOR CLINICAL STUDY; POPULATION GENETICS; PRIORITY JOURNAL;

EID: 0034640708     PISSN: 15524841     EISSN: 1552485X     Source Type: Journal    
DOI: 10.1002/1096-8628(20000612)96:3<268::aid-ajmg6>3.0.co;2-%23     Document Type: Article

References (27)

1. Adamson MD, Kennedy J, Petronis A, Dean M, Virkkunen M, Linnoila M, Goldman D. 1995. DRD4 dopamine receptor genotype and CSF monamine metabolites in Finnish alcoholics and controls. Am J Med Gen (Neuropsych Genet) 60:99-205.
2. Ashershon P, Curran S, Simanoff E, Taylor E.1997. Candidate gene studies in Attention Deficit Hyperactivity Disorder (abstract). Am J Med Genet (Neuropsych Genet) 74:631.
3. Barkley RA. 1990. Attention deficit hyperactivity disorder: a handbook for diagnosis and treatment. New York: Guiford.
4. Castellanos FX. 1997. Neuroimaging of attention deficit hyperactivity disorder. Child Adolesc Psychiat Clin North Am 6:383-411.
5. Castellanos FX, Lau E, Tayebi N, Lee P, Long RE, Giedd JN, Sharp W, Marsh WL, Walter JM, Hamburger SD, Ginns El Rapoport JL, Sidransky E. 1998. Lack of association between a dopamine-4 receptor polymorphism and attention deficit hyperactivity disorder: genetic and brain morphometric analyses. Mol Psychiatry 3:431-434.
6. Castellanos FX, Lewczyk CM, Fernandez T, Koprivica V, Kashani A, Tayebi N, Ginns EI, Sidransky E. 1999. Lack of an association between dopamine transporter (DAT1) and ADHD. Mol Psychiatry 4:S 80.
7. Chang F, Kidd JR, Livak KJ, Pakstis AJ, Kidd KK. 1996. The world-wide distribution of allele frequencies at the human dopamine D4 receptor locus. Hum Genet 98:91-101.
8. Civelli O, Bunzow JR, Grandy DK, Zhou Q-Y, Van Tol HHM. 1991. Molecular biology of the dopamine receptors. Eur J Pharmacol (Mol Pharmacol Section) 207:277-286.
9. Comings DE, Comings BG, Muhleman D, Dietz G, Shahbahrami B, Tast D, Knell E, Kocsis P, Baungarten R, Kovacs BW. 1991. The dopamine D2 receptor locus as a modifying gene in neuropsychiatric disorders. J Am Med Assoc 266:1793-1800.
10. Comings DE, Wu S, Chiu H, Ring RH, Gade R, Ahn C, MacMurray JP, Dietz G, Muhleman D. 1996. Polygenetic inheritance of Tourette's syndrome, stuttering, attention deficit hyperactivity, conduct and oppositional defiant disorder: the additive and subtractive effect of the three dopaminergic genes - DRD2, DBH and DAT1. Am J Med Genet (Neuropsych Genet) 67:264-288.
11. Cook EH, Stein MA, Krasowski MD, Cox NJ, Olkon DM, Kieffer JE, Leventhal BL. 1995. Association of attention-deficit hyperactivity disorder and the dopamine transporter gene. Am J Hum Genetics 56:993-998.
12. Daly G, Hawi Z, Fitzgerald M, Gill M. 1999. Mapping susceptibility loci in attention deficit hyperactivity disorder: preferential transmission of parental alleles at DAT1, DBH and DRD5 to affected children. Mol Psychiatry 4:192-196.
13. Faraone SV, Biederman J, Weiffenbach B, Keith T, Chu MP, Weaver A, Spencer TJ, Wilens TE, Frazier J, Cleves M, Sakai J. 1999. Dopamine D4 gene 7-receptor allele and attention hyperactivity disorder. Am J psychiatry 156:768-770.
14. Gelernter J, Kennedy JL, van Tol HH, Civelli O, Kidd KK. 1992. The D4 dopamine receptor (DRD4) maps to distal 11p close to HRAS. Genomics 13:208-210.
15. Gill M, Daly G, Heron S, Hawi Z, Fitzgerald M. 1997. Confirmation of association between attention deficit hyperactivity disorder and a dopamine transporter polymorphism. Mol Psychiatry 12:311-313.
16. Gjone H, Stevenson J, Sundet JM. 1996. Genetic influence on parent-reported attention related problems in Norwegian general population twin sample. J Am Acad Child Adolesc Psychiatry 35:588-596.
17. LaHoste GL, Swanson JM, Wigal SB, Glabe C, Wigal T, King N, Kennedy JL. 1996. Dopamine D4 receptor gene polymorphism is associated with attention deficit hyperactivity disorder. Mol Psychiatry 1:121-124.
18. Lander E and Kruglyak L. 1995. Genetic dissection of complex traits: guidelines for interpreting and reporting linkage results. Nat Genet 11:241-247.
19. Levy F, Hay DA, McStephen M, Wood C. 1997. Attention deficit hyperactivity disorder: a category or continuum? J Am Acad Child Adolesc Psychiatry 36:737-744.
20. Lichter JB, Barr CL, Kennedy JL, Van Tol HHM, Kidd KK, Livak KJ. 1993. A hypervariable segment in the human dopamine receptor D4 (DRD4) gene. Hum Mol Genet 6:767-773.
21. Meador-Woodruff JH, Grandy DK, Van Tol HHM, Damask SP, Little KY. 1994. Dopamine receptor gene expression in the human medial temporal lobe. Neuropsychopharmacology 10:239-248.
22. Palmer CGS, Bailey JU, Ramsey C, Cantwell D, Sinsheimer JS, De'Homme M, McGough J, Woodward JA, Asarnow R, Nelson S, Smalley SL. 2000. DAT1 and attention deficit hyperactivity disorder: is there genetic heterogeneity between familial with a single affected and multiple affected children? Am J Hum Genet (in press).
23. Rowe DC, Stever C, Giendinghagen LN, Gard JMC, Cleveland HH, Terris ST, Mohr JH, Shermans S, Abramowitz A, Waldman ID. 1998. Dopamine DRD4 receptor polymorphism and attention deficit hyperactivity disorder. Mol Psychiatry 3:419-426.
24. Smalley SL, Bailey JN, Palmer CG, Cantwell DP, McGough JJ, Del'Homme MA, Asarnow JR, Woodward JA, Ramsey C, Nelson SF. 1998. Evidence that the dopamine D4 receptor is a susceptibility gene in attention deficit. Mol Psychiatry 3:427-430.
25. Swanson JM, Sunohara GA, Kennedy JL, Regino R, Fineberg E, Wigal T, Lerner M, Williams L, LaHoste GJ, Wigal S. 1998. Association of the dopamine receptor D4 (DRD4) gene with a refined phenotype of attention deficit hyperactivity disorder (ADHD): a family-based approach. Mol Psychiatry 3:38-41.
26. Waldman ID, Rowe DC, Abramowitz A, Kozel ST, Mohr JH, Sherman SL, Cleveland HH, Sanders ML, Gard JM, Stever C. 1998. Association and linkage of the dopamine transporter gene and attention-deficit hyperactivity disorder in children: heterogeneity owing to diagnostic subtype and severity. Am J Hum Genet 63:1767-1776.
27. Ward MF, Wender PH, Reimherr FW. 1993. The Wender Utah Rating Scale: an aid in the retrospective diagnosis of childhood attention deficit hyperactivity disorder. Am J Psychiatry 150:885-890.