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Volumn 289, Issue 3, 2000, Pages 209-212

1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced complex I inhibition is reversed by disulfide reductant, dithiothreitol in mouse brain

Author keywords

1 Methyl 4 phenyl 1,2,3,6 tetrahydropyridine; Brain; Complex I; Mitochondria; Oxidative stress; Protein thiol

Indexed keywords

1,2,3,6 TETRAHYDRO 1 METHYL 4 PHENYLPYRIDINE; ANTIOXIDANT; DISULFIDE; DITHIOTHREITOL; GLUTATHIONE PEROXIDASE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE (UBIQUINONE);

EID: 0034637078     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0304-3940(00)01300-8     Document Type: Article
Times cited : (28)

References (19)
  • 1
    • 0017184389 scopus 로고
    • A rapid and sensitive method for the quantification of microgram quantities of protein utilizing the principle of dye-binding
    • Bradford M.M. A rapid and sensitive method for the quantification of microgram quantities of protein utilizing the principle of dye-binding. Anal. Biochem. 72:1976;248-254.
    • (1976) Anal. Biochem. , vol.72 , pp. 248-254
    • Bradford, M.M.1
  • 2
    • 0032557511 scopus 로고
    • Energy thresholds in brain mitochondria: Potential involvement in neurodegeneration
    • Davey G.P., Peuchen S., Clark J.B. Energy thresholds in brain mitochondria: potential involvement in neurodegeneration. J. Biol. Chem. 273:1988;12753-12757.
    • (1988) J. Biol. Chem. , vol.273 , pp. 12753-12757
    • Davey, G.P.1    Peuchen, S.2    Clark, J.B.3
  • 3
    • 0025915639 scopus 로고
    • NADH, ubiquinone oxidoreductase from bovine mitochondria
    • Dupuis A., Skehel J.M., Walker J.E. NADH, ubiquinone oxidoreductase from bovine mitochondria. Biochem. J. 277:1991;11-15.
    • (1991) Biochem. J. , vol.277 , pp. 11-15
    • Dupuis, A.1    Skehel, J.M.2    Walker, J.E.3
  • 4
    • 0013939811 scopus 로고
    • 3H-DOPA in various regions of the rat brain
    • 3H-DOPA in various regions of the rat brain. J. Neurochem. 13:1966;655-669.
    • (1966) J. Neurochem. , vol.13 , pp. 655-669
    • Glowinsky, J.1    Iversen, L.L.2
  • 5
    • 0027965971 scopus 로고
    • Characterization of the inhibitory mechanism of 1-methyl-4-phenyl pyridinium and 4-phenyl pyridine analogs in inner membrane preparations
    • Gluck M.R., Krueger M.J., Ramsay R.R., Sablin O.S., Singer T.P., Nicklas W.J. Characterization of the inhibitory mechanism of 1-methyl-4-phenyl pyridinium and 4-phenyl pyridine analogs in inner membrane preparations. J. Biol. Chem. 269:1994;3167-3174.
    • (1994) J. Biol. Chem. , vol.269 , pp. 3167-3174
    • Gluck, M.R.1    Krueger, M.J.2    Ramsay, R.R.3    Sablin, O.S.4    Singer, T.P.5    Nicklas, W.J.6
  • 7
    • 0010305496 scopus 로고
    • Preparing neural tissue for metabolite studies in isolation
    • H. McIlwain. London: Churchill Livingstone
    • McIlwain H. Preparing neural tissue for metabolite studies in isolation. McIlwain H. Practical Neurochemistry. 1975;105-132 Churchill Livingstone, London.
    • (1975) Practical Neurochemistry , pp. 105-132
    • McIlwain, H.1
  • 9
    • 0021810979 scopus 로고
    • Inhibition of NADH-linked oxidation of brain mitochondria by 1-methyl-4-phenyl pyridinium, a metabolite of the neurotoxin, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)
    • Nicklas W.J., Vyas I., Heikkila R.E. Inhibition of NADH-linked oxidation of brain mitochondria by 1-methyl-4-phenyl pyridinium, a metabolite of the neurotoxin, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). Life Sci. 36:1985;2503-2508.
    • (1985) Life Sci. , vol.36 , pp. 2503-2508
    • Nicklas, W.J.1    Vyas, I.2    Heikkila, R.E.3
  • 10
    • 0025848858 scopus 로고
    • A simple and inexpensive slicer for preparation of brain slices
    • Pai K.S., Shankar S.K., Ravindranath V. A simple and inexpensive slicer for preparation of brain slices. J. Neurosci. Methods. 37:1991;209-214.
    • (1991) J. Neurosci. Methods , vol.37 , pp. 209-214
    • Pai, K.S.1    Shankar, S.K.2    Ravindranath, V.3
  • 12
    • 0022516015 scopus 로고
    • Inhibition of mitochondrial NADH dehydrogenase by pyridine derivatives and its possible relation to experimental and idiopathic Parkinsonism
    • Ramsay R.R., Salach J.I., Dadgar J., Singer T.P. Inhibition of mitochondrial NADH dehydrogenase by pyridine derivatives and its possible relation to experimental and idiopathic Parkinsonism. Biochem. Biophys. Res. Commun. 135:1986;269-275.
    • (1986) Biochem. Biophys. Res. Commun. , vol.135 , pp. 269-275
    • Ramsay, R.R.1    Salach, J.I.2    Dadgar, J.3    Singer, T.P.4
  • 14
    • 0025298423 scopus 로고
    • Glutathione depletion and formation of glutathione-protein mixed disulfide following exposure of brain mitochondria to oxidative stress
    • Ravindranath V., Reed D.J. Glutathione depletion and formation of glutathione-protein mixed disulfide following exposure of brain mitochondria to oxidative stress. Biochem. Biophys. Res. Commun. 169:1990;1075-1079.
    • (1990) Biochem. Biophys. Res. Commun. , vol.169 , pp. 1075-1079
    • Ravindranath, V.1    Reed, D.J.2
  • 15
    • 0029095120 scopus 로고
    • Glutathione and protein thiol homeostasis in brain during reperfusion following cerebral ischemia
    • Shivakumar B.R., Kolluri S.V.R., Ravindranath V. Glutathione and protein thiol homeostasis in brain during reperfusion following cerebral ischemia. J. Pharmacol. Exp. Ther. 274:1995;1117-1167.
    • (1995) J. Pharmacol. Exp. Ther. , vol.274 , pp. 1117-1167
    • Shivakumar, B.R.1    Kolluri, S.V.R.2    Ravindranath, V.3
  • 16
    • 0028837133 scopus 로고
    • Carbidopa/levodopa and selegiline do not affect platelet mitochondrial function in early Parkinsonism
    • Shults C.W., Nasirian F., Ward D.M., Nakano K., Pay M., Hill L.R., Haas R.H. Carbidopa/levodopa and selegiline do not affect platelet mitochondrial function in early Parkinsonism. Neurology. 45:1995;344-348.
    • (1995) Neurology , vol.45 , pp. 344-348
    • Shults, C.W.1    Nasirian, F.2    Ward, D.M.3    Nakano, K.4    Pay, M.5    Hill, L.R.6    Haas, R.H.7
  • 17
    • 0031036391 scopus 로고    scopus 로고
    • Evidence for generation of oxidative stress in brain by MPTP: In vitro and in vivo studies in mice
    • Sriram K., Pai K.S., Boyd M.R., Ravindranath V. Evidence for generation of oxidative stress in brain by MPTP: in vitro and in vivo studies in mice. Brain Res. 749:1997;44-52.
    • (1997) Brain Res. , vol.749 , pp. 44-52
    • Sriram, K.1    Pai, K.S.2    Boyd, M.R.3    Ravindranath, V.4
  • 18
    • 0027504297 scopus 로고
    • Advances in our understanding of the mechanisms of the neurotoxicity of MPTP and related compounds
    • Tipton K.F., Singer T.P. Advances in our understanding of the mechanisms of the neurotoxicity of MPTP and related compounds. J. Neurochem. 61:1993;1191-1206.
    • (1993) J. Neurochem. , vol.61 , pp. 1191-1206
    • Tipton, K.F.1    Singer, T.P.2
  • 19
    • 0024996681 scopus 로고
    • The oxidative inactivation of mitochondrial electron transport chain components and ATPase
    • Zhang Y., Marcillat O., Giulivi G., Ernster L., Davies K.J.A. The oxidative inactivation of mitochondrial electron transport chain components and ATPase. J. Biol. Chem. 265:1990;16330-16336.
    • (1990) J. Biol. Chem. , vol.265 , pp. 16330-16336
    • Zhang, Y.1    Marcillat, O.2    Giulivi, G.3    Ernster, L.4    Davies, K.J.A.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.