The contribution of a conformationally mobile, active site loop to the reaction catalyzed by glutamate semialdehyde aminomutase

Journal of Biological Chemistry

Volumn 275, Issue 6, 2000, Pages 3879-3886

  Contestabile, Roberto ^a   Angelaccio, Sebastiana ^b   Maytum, Robin ^a,c   Bossa, Francesco ^b   John, Robert A ^a,d  

^a CARDIFF UNIVERSITY   (United Kingdom)

^b SAPIENZA UNIVERSITY OF ROME   (Italy)

^c UNIVERSITY OF KENT   (United Kingdom)

^d CARDIFF UNIVERSITY   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ALDEHYDE; AMINOLEVULINIC ACID; GLUTAMIC ACID DERIVATIVE; MUTASE; PYRROLE DERIVATIVE;

ARTICLE; BINDING SITE; CATALYSIS; ENZYME ACTIVE SITE; ENZYME CONFORMATION; ENZYME KINETICS; ENZYME MECHANISM; PRIORITY JOURNAL; SITE DIRECTED MUTAGENESIS;

FELIS CATUS;

EID: 0034635371     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.275.6.3879     Document Type: Article

References (18)

1. Kannangara, G., Gough, S. P., Bryant, P., Hoober, J. K., Kahn, A., and von Wettstein, D. (1988) Trends Biochem. Sci. 13, 139-143
2. Hennig, M., Grimm, B., Contestabile, R., John, R. A., and Jansonius, J. N. (1997) Proc. Natl. Acad. Sci. U. S. A. 94, 4866-4871
3. Shen, B. W., Hennig, M., Hohenester, E., Jansonius, J. N., and Schirmer, T. J. Mol. Biol. 277, 81-102
4. Smith, M. A. Kannangara, C. G., Grimm, B., and von Wettstein, D. (1991) Eur. J. Biochem. 202, 749-757
5. Pugh, C. E., Harwood, J. L., and John, R. A. (1992) J. Biol. Chem. 267, 1584-1588
6. Tyacke, R. J. Harwood, J. L., and John, R. A. (1993) Biochem. J. 293, 697-701
7. Smith, M. A., King, P. J., and Grimm, B. (1998) Biochemistry 37, 319-329
8. Grimm, B., Smith, A. J., Kannangara, C. G., and Smith, M. A. (1991) J. Biol. Chem. 266, 12495-12501
9. Pugh, C. E., Nair, S. P., Harwood, J. L., and John, R. A. (1991) Anal. Biochem. 198, 43-46
10. Higuchi, R., Innis, M. A., Gelfand, D. H., Snisky, J. J., and White, T. J. (1990) in PCR Protocols: A Guide to Methods and Applications (Higuchi, R., Innis, M. A., Gelfand, D. H., Snisky, J. J., and White, T. J., eds) pp. 177-183, Academic Press, Inc., San Diego
11. Eccleston, J. F. Messerschmidt, R. G., and Yates, D. W. (1980) Anal. Biochem. 106, 73-77
12. Peterson, E. A., and Sober, H. A. (1954) J. Am. Chem. Soc. 76, 169-175
13. Kallen, R. G., Korpela, T., Martell, A. E., Matsushima, Y., Metzler, C. M., Metzler, D. E., Morozov, Y. V., Ralston, I. M., Savin, F. A., Torchinsky, Y. M., and Ueno, I. (1985) in Transaminases (Christen, P., and Metzler, D. E., eds) pp. 37-108, Wiley-Interscience, New York
14. Pogson, C. I., and Wolfe, R. G. (1972) Biochem. Biophys. Res. Commun. 46, 1043-1054
15. Tyacke, R. J., Contestabile, R., Grimm, B., Harwood, J. L., and John, R. A. (1995) Biochem. J. 309, 307-313
16. Grishin, N. V., Phillips, M. A., and Goldsmith, E. J. (1995) Protein Sci. 4, 1291-1304
17. Clarke, A. R., Wigley, D. B., Chia, W. N., Barstow, D., Atkinson, T., and Holbrook, J. J. (1986) Nature 324, 699-702
18. Pompliano, D. L., Peyman, A., and Knowles, J. R. (1990) Biochemistry 29, 3186-3194