An autoradiographic study in μ-opioid receptor knockout mice

Molecular Brain Research

Volumn 76, Issue 1, 2000, Pages 170-172

  Chen, Hung Chun ^a   Seybold, Virginia S ^a   Loh, Horace H ^a  

^a UNIVERSITY OF MINNESOTA   (United States)

Author keywords

Autoradiography; Knock out mice; Opioid receptor

Indexed keywords

ENKEPHALIN[2 DEXTRO ALANINE 4 METHYLPHENYLALANINE 5 GLYCINE]; LEVORPHANOL; MU OPIATE RECEPTOR;

ANIMAL EXPERIMENT; AUTORADIOGRAPHY; BINDING SITE; DRUG RECEPTOR BINDING; GENE EXPRESSION; KNOCKOUT MOUSE; MOUSE; NONHUMAN; PRIORITY JOURNAL; SHORT SURVEY;

EID: 0034629421     PISSN: 0169328X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0169-328X(99)00346-0     Document Type: Article

References (11)

1. Kitchen I., Slowe S.J., Matthes H.W.D., Kieffer B.L. Quantitative autoradiographic mapping of μ-, δ- and κ-opioid receptors in knockout mice lacking the μ-opioid receptor gene. Brain Res. 778:1997;73-88.
2. Loh H.H., Liu H.C., Cavalli A., Yang W., Chen Y.F., Wei L.N. Mu opioid receptor knockout in mice: effects on ligand-induced analgesia and morphine lethality. Mol. Brain Res. 54:1998;321-326.
3. Matthes H.W.D., Maldonado R., Simonin F., Valverde O., Slowe S., Kitchen I., Befort K., Dierich A., Meur M.L., Dolle P., Tzavara E., Hanoune J., Roques B.P., Kieffer B.L. Loss of morphine-induced analgesia, reward effect and withdrawal symptoms in mice lacking the mu-opioid receptor gene. Nature. 383:1996;819-823.
4. Roy S., Liu H.C., Loh H.H. mu opioid receptor-knockout mice: the role of mu opioid receptor in gastrointestinal transit. Mol. Brain Res. 56:1998;281-283.
5. Schoffelmer A.N.M., Hogenboom F., Mulder A.H. Inhibition of dopamine-sensitive adenylate cyclase by opioids: possible involvement of physically associated μ- and δ-opioid receptors. Naunyn-Schmiedeberg's Arch. Pharmacol. 335:1987;278-284.
6. Schuller A.G.P., King M.A., Zhang J., Bolan E., Pan Y.X., Morgan D.J., Chang A., Czick M.E., Unterwald E.M., Pasternak G.W., Pintar J.E. Retention of heroin and morphine-6b-glucuronide analgesia in a new line of mice lacking exon 1 of MOR-1. Nat. Neurosci. 2:1999;151-156.
7. Sora I., Funada M., Uhl G.R. The m-opioid receptor is necessary for [D-Pen2, D-Pen5]enkephalin-induced analgesia. Eur. J. Pharmacol. 324:1997;R1-R2.
8. Sora I., Li X.F., Funada M., Kinsey S., Uhl G.R. Visceral chemical nociception in mice lacking μ-opioid receptors: effects of morphine, SNC80 and U-50,488. Eur. J. Pharmacol. 366:1999;R3-R5.
9. Sora I., Takahashi N., Funada M., Ujike H., Revay R.S., Donovan D.M., Miner L.L., Uhl G.R. Opiate receptor knockout mice define mu opioid receptor roles in endogenous nociceptive responses and morphine-induced analgesia. Proc. Natl. Acad. Sci. U.S.A. 94:1997;1544-1549.
10. Stevens C.W., Lacey C.B., Miller K.E., Elde R.P., Seybold V.S. Biochemical characterization and regional quantification of mu, delta and kappa opioid binding sites in rat spinal cord. Brain Res. 550:1991;77-85.
11. Tian M., Broxmeyer H.E., Fan Y., Lai Z., Zhang S., Aronica S., Cooper S., Bigsby R.M., Steinmetz R., Engle S.J., Mestek A., Pollock J.D., Lehman M.N., Jansen H.T., Ying M., Stambrook P.J., Tischfield J.A., Yu L. Altered hematopoiesis, behavior, and sexual function in mu opioid receptor-deficient mice. J. Exp. Med. 185:1997;1517-1522.