The α1/2 helical backbone of the prodomains defines the intrinsic inhibitory specificity in the cathepsin L-like cysteine protease subfamily

FEBS Letters

Volumn 469, Issue 2-3, 2000, Pages 203-207

  Guo, Ying Lan ^a   Kurz, Ursula ^a   Schultz, J E ^a   Lim, Chin Chia ^b   Wiederanders, B ^b   Schilling, K ^b  

^a UNIVERSITY OF TÜBINGEN   (Germany)

^b FRIEDRICH SCHILLER UNIVERSITY JENA   (Germany)

Author keywords

Inhibition kinetics; Papain family; Paramecium; Propeptide; Specificity

Indexed keywords

CATHEPSIN L; CATHEPSIN S; CYSTEINE PROTEINASE; PAPAIN; SYNTHETIC PEPTIDE; CATHEPSIN; HYBRID PROTEIN; PROTEINASE;

ANIMAL EXPERIMENT; ARTICLE; CHIMERA; CONFORMATION; ENZYME INHIBITION; ENZYME KINETICS; ENZYME SPECIFICITY; ENZYME STRUCTURE; NONHUMAN; PARAMECIUM; PRIORITY JOURNAL; PROTEIN EXPRESSION; AMINO ACID SEQUENCE; ANIMAL; CELL LINE; CHEMISTRY; HUMAN; KINETICS; MOLECULAR GENETICS; PROTEIN SECONDARY STRUCTURE; PROTEIN TERTIARY STRUCTURE; SEQUENCE ANALYSIS; STRUCTURE ACTIVITY RELATION;

AMINO ACID SEQUENCE; ANIMALS; CATHEPSINS; CELL LINE; CYSTEINE ENDOPEPTIDASES; ENDOPEPTIDASES; HUMANS; KINETICS; MOLECULAR SEQUENCE DATA; PARAMECIUM; PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY; RECOMBINANT FUSION PROTEINS; SEQUENCE ANALYSIS, PROTEIN; STRUCTURE-ACTIVITY RELATIONSHIP; SUBSTRATE SPECIFICITY;

EID: 0034628674     PISSN: 00145793     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-5793(00)01281-3     Document Type: Article

References (25)

1. Smith S.M., Gottesman M.M. J. Biol. Chem. 264:1989;20487-20495.
2. Tao K., Stearns N.A., Dong J., Wu Q.L., Sahagian G.G. Arch. Biochem. Biophys. 311:1994;19-27.
3. Nomura T., Fujisawa Y. Biochem. Biophys. Res. Commun. 230:1997;143-146.
4. McIntyre G.F., Godbold G.D., Erickson A.H. J. Biol. Chem. 269:1994;567-572.
5. Mach L., Mort J.S., Glossl J. J. Biol. Chem. 269:1994;13030-13035.
6. Menard R., Carmona E., Takebe S., Dufour E., Plouffe C., Mason P., Mort J.S. J. Biol. Chem. 273:1998;4478-4484.
7. Jerala R., Zerovnik E., Kidric J., Turk V. J. Biol. Chem. 273:1998;11498-11504.
8. Fox T., de Miguel E., Mort J.S., Storer A.C. Biochemistry. 31:1992;12571-12576.
9. Taylor M.A., Briggs G.S., Baker K.C., Cummings N.J., Pratt K.A., Freedman R.B., Goodenough P.W. Biochem. Soc. Trans. 23:1995;80S.
10. Carmona E., Dufour E., Plouffe C., Takebe S., Mason P., Mort J.S., Menard R. Biochemistry. 35:1996;8149-8157.
11. Völkel H., Kurz U., Linder J., Klumpp S., Gnau V., Jung G., Schultz J.E. Eur. J. Biochem. 238:1996;198-206.
12. Maubach G., Schilling K., Rommerskirch W., Wenz I., Schultz J.E., Weber E., Wiederanders B. Eur. J. Biochem. 250:1997;745-750.
13. Visal S., Taylor M.A., Michaud D. FEBS Lett. 434:1998;401-405.
14. McGrath M.E., Palmer J.T., Brömme D., Somoza J.R. Protein Sci. 7:1998;1294-1302.
15. Kirschke H., Wiederanders B. Methods Enzymol. 244:1994;500-511.
16. Wiederanders B., Brömme D., Kirschke H., von Figura K., Schmidt B., Peters C. J. Biol. Chem. 267:1992;13708-13713.
17. Cha S. Biochem. Pharmacol. 24:1975;2177-2185.
18. Baici A. Biol. Chem. 379:1998;1007-1018.
19. Taylor M.A., Baker K.C., Briggs G.S., Connerton I.F., Cummings N.J., Pratt K.A., Revell D.F., Freedman R.B., Goodenough P.W. Protein Eng. 8:1995;59-62.
20. Coulombe R., Grochulski P., Sivaraman J., Menard R., Mort J.S., Cygler M. EMBO J. 15:1996;5492-5503.
21. Groves M.R., Taylor M.A., Scott M., Cummings N.J., Pickersgill R.W., Jenkins J.A. Structure. 4:1996;1193-1203.
22. LaLonde J.M., Zhao B., Janson C.A., D'Alessio K.J., McQueney M.S., Orsini M.J., Debouck C.M., Smith W.W. Biochemistry. 38:1999;862-869.
23. Sivaraman J., Lalumiere M., Menard R., Cygler M. Protein Sci. 8:1999;283-290.
24. Groves M.R., Coulombe R., Jenkins J., Cygler M. Proteins. 32:1998;504-514.
25. Kreusch, S., Fehn, M., Maubach, G., Nissler, K., Rommerskirch, W., Schilling, K., Weber, E., Wenz, I. and Wiederanders, B. (1999) submitted for publication.