Myoepithelial-specific CD44 shedding is mediated by a putative chymotrypsin-like sheddase

Biochemical and Biophysical Research Communications

Volumn 279, Issue 1, 2000, Pages 116-123

  Lee, Maggie C ^a   Alpaugh, Mary L ^a   Nguyen, Mai ^a   Deato, Maria ^a   Dishakjian, Lena ^a   Barsky, Sanford H ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Anti invasion; Antiangiogenesis; CD44; Chymotrypsin; Myoepithelial cells; PMA; Sheddase

Indexed keywords

1,10 PHENANTHROLINE; ALPHA 1 ANTICHYMOTRYPSIN; CHYMOSTATIN; CHYMOTRYPSIN; HERMES ANTIGEN; MARIMASTAT; MEMBRANE ANTIGEN; PHORBOL 13 ACETATE 12 MYRISTATE; PLASMIN; SHEDDASE; SQUAMOUS CELL CARCINOMA ANTIGEN; TISSUE INHIBITOR OF METALLOPROTEINASE 1; TOSYLPHENYLALANYL CHLOROMETHYL KETONE; UNCLASSIFIED DRUG;

ANTIGEN SPECIFICITY; ARTICLE; CELL FRACTIONATION; CELL KINETICS; CELL MEMBRANE TRANSPORT; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ACTIVITY; HUMAN; HUMAN CELL; MYOEPITHELIUM CELL; PRIORITY JOURNAL;

EID: 0034627120     PISSN: 0006291X     EISSN: None     Source Type: Journal    
DOI: 10.1006/bbrc.2000.3918     Document Type: Article

References (46)

1. The human myoepithelial cell is a natural tumor suppressor
2. The myoepithelial defense: A host defense against cancer
3. The human myoepithelial cell exerts antiproliferative effects on breast carcinoma cells characterized by p21WAF1/CIP1 induction, G2/M arrest, and apoptosis
4. Should DCIS be renamed carcinoma of the ductal system?
5. Establishment and characterization of a novel human myoepithelial cell line and matrix-producing xenograft from a parotid basal cell adenocarcinoma
6. Characterizations of the extracellular matrix and proteinase inhibitor content of human myoepithelial tumors
7. The human myoepithelial cell displays a multifaceted anti-angiogenic phenotype
8. Extensive apoptosis in ductal carcinoma in situ of the breast
9. Myoepithelial-specific CD44 shedding contributes to the anti-invasive and antiangiogenic phenotype of myoepithelial cells
10. Hydrophobic association of calpains with subcellular organelles - Compartmentalization of calpains and the endogenous inhibitor calpastatin in tissues
11. A siren song from tumor cells
12. Cancer metastasis and angiogenesis: An imbalance of positive and negative regulation
13. Angiogenic factors
14. Fibroblast cell interactions with human melanoma cells affect tumor cell growth as a function of tumor progression
15. Coexpression of CD44 variant (v10/ex14) and CD44S in human mammary epithelial cells promotes tumorigenesis
16. CD44 is involved in tumor angiogenesis; an activation antigen on human endothelial cells
17. CD44-related chondroitin sulfate proteoglycan, a cell surface receptor implicated with tumor cell invasion mediates endothelial cell migration on fibrinogen and invasion into a fibrin matrix
18. Interaction between CD44 and hyaluronate is directly implicated in the regulation of tumor development
19. The loss of expression of CD44 standard and variant isoforms is related to prostatic carcinoma development and tumor progression
20. Diverse cell surface protein ectodomains are shed by a system sensitive to metalloprotease inhibitors
21. Regulated CD44 cleavage under the control of protein kinase C, calcium influx, and the Rho family of small G proteins
22. CD44 cleavage induced by a membrane-associated metalloprotease plays a critical role in tumor cell migration
23. Expression of antisense CD44 variant 6 inhibits colorectal tumor metastasis and tumor growth in a wound environment
24. Migration of highly aggressive melanoma cells on hyaluronic acid is associated with functional changes, increased turnover and shedding of CD44 receptors
25. Further evidence for a common mechanism for shedding of cell surface proteins
26. Hyaluronidases in tissue invasion
27. Shedding of the CD44 adhesion molecule from leukocytes induced by anti-CD44 monoclonal antibody simulating the effect of a natural receptor ligand
28. Early detachment of colon carcinoma cells during CD95 (APO-1/Fas)-mediated apoptosis I. De-adhesion from hyaluronate by shedding of CD44
29. The role of hyaluronan in tumour neovascularization
30. Correlation of CD44 expression with proliferative activity of normal human breast epithelial cells in culture
31. Migration of highly aggressive MV3 melanoma cells in 3-dimensional collagen lattices results in local matrix reorganization and shedding of α2 and β1 integrins and CD44
32. Membrane proteins with soluble counterparts: Role of proteolysis in the release of transmembrane proteins
33. Metalloprotease and serine proteases are involved in cleavage of CD43 CD44, and CD16 from stimulated human granulocytes
34. A cellular striptease act
35. Down-regulation by tumor necrosis faetor-α of neutrophil cell surface expression of the sialophorin CD43 and the hyaluronate receptor CD44 through a proteolytic mechanism
36. Shedding of the lymphocyte L-selectin adhesion molecule is inhibited by a hydroxamic acid-based protease inhibitor
37. Membrane protein secretases
38. The Notch1 receptor is cleaved constitutively by a furin-like convertase
39. Metalloproteinase-mediated regulation of L-selectin levels on leucocytes
40. Synthetic matrix metalloproteinase inhibitors and tissue inhibitor of metalloproteinase (TIMP)-2, but not TIMP-1, inhibit shedding of tumor necrosis factor-α receptors in a human colon adenocarcinoma (Colo 205) cell line
41. A metalloproteinase inhibitor blocks the shedding of soluble cytosine receptors and processing of transmembrane cytokine precursors in human monocytic cells
42. Squamous cell carcinoma antigen 2 is a novel serpin that inhibits the chymotrypsin-like proteinases cathepsin G and mast cell chymase
43. SCCA1 and SCCA2 are proteinase inhibitors that map to the serpin cluster at 18q21.3
44. Factors influencing chelator-stable, detergent-extractable, phorbol diester-induced membrane association of protein kinase C
45. Evidence of involvement of CD44 in endothelial cell proliferation, migration and angiogenesis in vitro
46. Induction of apoptosis of metastatic mammary carcinoma cells in vivo by disruption of tumor cell surface CD44 function