Oncogenic insertional mutations in the P-loop of Ras are overactive in MAP kinase signaling

Oncogene

Volumn 19, Issue 47, 2000, Pages 5367-5376

  Klockow, Boris ^a,b   Ahmadia, Mohammad R ^a   Block, Christoph ^a   Wittinghofer, Alfred ^a  

^a MAX PLANCK INSTITUTE OF MOLECULAR PHYSIOLOGY   (Germany)

^b MAX PLANCK INSTITUTE FOR MEDICAL RESEARCH   (Germany)

Author keywords

GTPase; Map kinase pathway; Oncogene; Ras

Indexed keywords

MITOGEN ACTIVATED PROTEIN KINASE; RAS PROTEIN;

ANIMAL CELL; ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ACTIVITY; GENE INSERTION; GENE MUTATION; HUMAN; MICROINJECTION; MOLECULAR CLONING; NERVE FIBER GROWTH; NONHUMAN; ONCOGENE RAS; PRIORITY JOURNAL; PROTEIN BINDING; SIGNAL TRANSDUCTION;

ANIMALS; BINDING SITES; CLONING, MOLECULAR; GENE EXPRESSION; GENES, RAS; GTP PHOSPHOHYDROLASES; GUANOSINE TRIPHOSPHATE; MITOGEN-ACTIVATED PROTEIN KINASES; MUTAGENESIS, INSERTIONAL; NUCLEOTIDES; ONCOGENE PROTEIN P21(RAS); PC12 CELLS; PHOSPHATES; PROTO-ONCOGENE PROTEINS C-RAF; RABBITS; RATS; SIGNAL TRANSDUCTION;

ANIMALIA;

EID: 0034626694     PISSN: 09509232     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.onc.1203909     Document Type: Article

References (64)