Ca2+-entry blockade by CAF603, a carotane sesquiterpene isolated from Trichoderma virens

European Journal of Pharmacology

Volumn 335, Issue 2-3, 1997, Pages 153-159

  Suarez Kurtz, Guilherme ^a   Nascimento, José H M ^a   Ondeyka, John G ^b   Kaczorowski, Gregory J ^b  

^a FEDERAL UNIVERSITY OF RIO DE JANEIRO   (Brazil)

^b MERCK RESEARCH LABORATORIES   (United States)

Author keywords

Ca2+ current; Ca2+ entry block; Excitation contraction coupling; K+ channel, Ca2+ activated; Natural product

Indexed keywords

CAF 603; CALCIUM CHANNEL; GLIBENCLAMIDE; IBERIOTOXIN; SESQUITERPENE; UNCLASSIFIED DRUG; CALCIUM CHANNEL BLOCKING AGENT; PEPTIDE; POTASSIUM CHANNEL BLOCKING AGENT;

ANIMAL TISSUE; ARTICLE; CALCIUM TRANSPORT; CONTROLLED STUDY; DETRUSOR MUSCLE; DRUG ISOLATION; DUODENUM; GUINEA PIG; HYPHOMYCETES; ILEUM; IN VITRO STUDY; MUSCLE CELL; MUSCLE TONE; NONHUMAN; PATCH CLAMP; PORTAL VEIN; PRIORITY JOURNAL; RABBIT; SMOOTH MUSCLE CONTRACTILITY; ANIMAL; BLADDER; CHEMISTRY; COMPARATIVE STUDY; CYTOLOGY; DRUG EFFECT; HEART MUSCLE; ISOLATION AND PURIFICATION; MUSCLE CONTRACTION; MUSCLE RELAXATION; PHYSIOLOGY; SMALL INTESTINE; SMOOTH MUSCLE; TRICHODERMA; VASCULAR SMOOTH MUSCLE;

ANIMALS; CALCIUM CHANNEL BLOCKERS; GLYBURIDE; GUINEA PIGS; INTESTINE, SMALL; MUSCLE CONTRACTION; MUSCLE RELAXATION; MUSCLE TONUS; MUSCLE, SMOOTH; MUSCLE, SMOOTH, VASCULAR; MYOCARDIUM; PATCH-CLAMP TECHNIQUES; PEPTIDES; POTASSIUM CHANNEL BLOCKERS; RABBITS; SESQUITERPENES; TRICHODERMA; URINARY BLADDER;

EID: 0030613696     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-2999(97)01206-5     Document Type: Article

References (16)

1. DeFarias F.P., Carvalho M.F., Lee S.H., Kaczorowski G.J., Suarez-Kurtz G. Effects of the potassium channel blockers paspalitrem-C and paxilline on mammalian smooth muscle. Eur. J. Pharmacol. 314:1996;123-128.
2. Galvez A., Gimenez-Gallego G., Reuben J.P., Roy-Contancin L., Feigelbaum P., Kaczorowski G.J., Garcia M.L. Purification and characterization of a unique, potent, peptidyl probe for the high-conductance calcium-activated potassium channel from venom of the scorpion Buthus tamulus. J. Biol. Chem. 265:1990;11083-11088.
3. Garcia M.L., Knaus H.-G., Munujos P., Slaughter R.S., Kaczorowski G.J. Charybdotoxin and its effects on potassium channels. Am. J. Physiol. 269:1995;C1-C10.
4. Hamill O.P., Marty A., Neher E., Sakmann B., Sigworth F.J. Improved patch clamp techniques for high-resolution current recordings from cells and cell-free membrane patches. Pflug. Arch. 391:1981;85-100.
5. Knaus H.-G., McManus O.B., Lee S.H., Schmalhofer W.A., Garcia-Calvo M., Helms L.M.H., Sanchez M., Giangiacomo K., Reuben J.P., Smith A.B. III, Kaczorowski G.J., Garcia M.L. Tremorgenic indole alkaloids potently inhibit smooth muscle high-conductance calcium-activated potassium channels. Biochemistry. 33:1994;5819-5828.
6. Lee S.H., Hensens O.D., Helms G.L., Liesch J.M., Zink D.L., Giacobe R.A., Bills G.F., Stevens-Miles S., Garcia M.L., Schmalhofer W.A., McManus O.B., Kaczorowski G.J. A novel sesquiterpenoid potassium channel-agonist from Trichoderma virens. J. Nat. Prod. 58:1995;1822-1828.
7. McManus O.B., Harris G.H., Giangiacomo K.M., Feigelbaum P., Reuben J.P., Addy M.E., Burka J.F., Kaczorowski G.J., Garcia M.L. An activator of calcium-dependent potassium channels isolated from a medicinal herb. Biochemistry. 32:1993;6128-6133.
8. Mostwin J.L. Receptor operated intracellular calcium stores in the smooth muscle of the guinea pig bladder. J. Urol. 133:1985;900-905.
9. Ca channel from Arthrinium phaeospermum. Bioorg. Med. Chem. Lett. 5:1995;733-734.
10. Perez M.A., Sarabanda A.V.L., Padilha W.L.N., Masuda M.O. Effect of salicylate on normal and digoxin intoxicated isolated rabbit heart. Braz. J. Med. Biol. Res. 17:1984;189-196.
11. Ca channels. J. Chem. Soc. Perkin Trans. 1:1994;3349-3352.
12. Suarez-Kurtz, G., 1993. Bloqueantes de los canales de calcio. In: Velazco, A., Lorenzo, P., Serrano J.S., Andres-Trellles, F. (Eds.), Velazquez - Farmacologia. Interamericana-McGraw-Hill, Barcelona, pp. 575-587.
13. Suarez-Kurtz G., Garcia M.L., Kaczorowski G.J. Effects of charybdotoxin and iberiotoxin on the spontaneous motility and tonus of different guinea pig smooth muscle tissues. J. Pharmacol. Exp. Ther. 259:1991;339-443.
14. Triggle, D.J., 1981. Calcium antagonists: Basic chemical and pharmacological aspects. In: Weiss, G.B. (Ed.), New Perspectives on Calcium Antagonists. American Physiological Society, Bethesda, MD, pp. 1-18.
15. Vazquez J., Feigelbaum P., Katz G.M., King V.F., Reuben J.P., Roy-Contancin L., Slaughter R.S., Kaczorowski G.J., Garcia M.L. Characterization of high affinity binding sites for charybdotoxin in sarcolemmal membranes from bovine aortic smooth muscle. J. Biol. Chem. 264:1989;20902-20909.
16. 3H ]nitrendipine binding Can. J. Physiol. Pharmacol. 63:1985;453-462.