Up-regulation of pituitary adenylate cyclase-activating polypeptide in urinary bladder pathways after chronic cystitis

Journal of Comparative Neurology

Volumn 420, Issue 3, 2000, Pages 335-348

  Vizzard, Margaret A ^a  

^a UNIVERSITY OF VERMONT COLLEGE OF MEDICINE   (United States)

Author keywords

Cyclophosphamide; Lateral collateral pathway; Lumbosacral spinal cord; Retrograde tracing; Urinary bladder; Visceral inflammation

Indexed keywords

HYPOPHYSIS ADENYLATE CYCLASE ACTIVATING POLYPEPTIDE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLADDER FUNCTION; CONTROLLED STUDY; CYSTITIS; ENZYME ACTIVATION; IMMUNOREACTIVITY; LABELING INDEX; MICTURITION REFLEX; NEUROTRANSMITTER RELEASE; NONHUMAN; PARASYMPATHETIC NERVE; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; RECEPTOR UPREGULATION; RETROGRADE NERVE FIBER TRANSPORT; SPINAL CORD DORSAL HORN;

EID: 0034621676     PISSN: 00219967     EISSN: None     Source Type: Journal    
DOI: 10.1002/(sici)1096-9861(20000508)420:3<335::aid-cne5>3.0.co;2-%23     Document Type: Article

References (70)

1. Arimura A, Somogyvari-Vigh A, Miyata A, Mizuno K, Coy DH, Kitada C. 1991. Tissue distribution of PACAP as determined by RIA: highly abundant in rat brain and testes. Endocrinology 129:2787-2789.
2. Beitel RE, Dubner. 1976. Response of unmyelinated (C) polymodal nociceptors to thermal stimuli applied to monkey's face. J Neurophysiol 39:1160-1175.
3. Birder LA, de Groat WC. 1993. Induction of c-fos expression in spinal neurons by nociceptive and nonnociceptive stimulation of the LUT. Am J Physiol 265:R326-R333.
4. Campbell JN, Meyer RA. 1986. Primary afferents and hyperaglesia. In: Yaksh TL, editor. Spinal afferent processing. New York: Plenum Press, p 59-81.
5. Coderre TJ, Katx J, Vaccarino AL, Melzack R. 1993. Contribution of central neuroplasticity to pathological pain: review of clinical and experimental evidence. Pain 52:259-285.
6. Cox PJ. 1979. Cyclophosphamide cystitis - identification of acrolein as the causative agent. Biochem Pharmacol 28:2045.
7. Damoiseaux JGMC, Dopp EA, Calame W, Chao D, MacPherson GG. 1994. Rat macrophage lysosomal membrane antigen recognized by monoclonal antibody ED1. Immunology 83:140-147.
8. de Groat WC, Kruse MN. 1993. Central processing and morphological plasticity in lumbosacral afferent pathways from the lower urinary tract. In: Mayer EA, Raybould HE, editors. Basic and clinical aspects of chronic abdominal pain. Pain research and clinical management. Amsterdam: Elsevier Science Publishers, p 219-235.
9. de Groat WC, Booth AM, Yoshimura N. 1993. Neurophysiology of micturition and its modification in animal models of human disease. In: Maggi CA, editor. The autonomic nervous system. London: Harwood Academic Publishers, p 227-290.
10. Dickinson T. Mitchell R, Robberecht P, Fleetwood-Walker SM. 1999. The role of VIP/PACAP receptor subtypes in spinal somatosensory processing in rats with experimental peripheral mononeuropathy. Neuropharmacology 38:167-180.
11. Dmitrieva N, McMahon SB. 1996. Sensitisation of visceral afferents by nerve growth factor in the adult rat. Pain 66:87-97.
12. Dmitrieva N, Shelton D, Rice ASC, McMahon SB. 1997. The role of nerve growth factor in a model of visceral inflammation. Neuroscience 78: 449-459.
13. Donaldson LF, Harmar AJ, McQueen DS, Seckl JR. 1992. Increased expression of preprotachykinin, calcitonin gene-related peptide, but not vasoactive intestinal peptide messenger RNA in dorsal root ganglia during the development of adjuvant monarthritis in the rat. Brain Res Mol Brain Res 16:143-149.
14. Donovan MK, Winternitz SR, Wyss JM. 1983. An analysis of the sensory innervation of the urinary system of the rat. Brain Res Bull 11:321-324.
15. Doone GV, Vizzard MA. 1998. Redistribution and increased numbers of Fos-immunoreactive (IR) cells in the lumbosacral (L6-S1) spinal cord induced by urinary bladder distension following chronic cyclophosphamide (CYP)-induced urinary bladder inflammation in the rat: effects of capsaicin. Soc Neurosci Abstr 24:1617.
16. Dubner R, Ruda MA. 1992. Activity dependent neuronal plasticity following tissue injury and inflammation. Trends Neurosci 15:96-103.
17. Eide FF, Lowenstein DH, Reichardt LF. 1993. Neurotrophins and their receptors - current concepts and implications for neurologic disease. Exp Neurol 121:200-214.
18. Fahrenkrug J, Hannibal J. 1998. Pituitary adenylate cyclase activating polypeptide immunoreactivity in capsaicin-sensitive nerve fibres supplying the rat urinary tract. Neuroscience 83:1261-1272.
19. Habler HJ, Jänig W, Koltzenburg M. 1990. Activation of unmyelinated afferent fibers by mechanical stimuli and inflammation of the urinary bladder in the cat. J Physiol 425:545-562.
20. Hanesch U, Pfrommer U, Grubb BD, Schaible H-G. 1993. Acute and chronic phases of unilateral inflammation in rat's ankle are associated with an increase in the proportion of calcitonin gene-related peptide-immunoreactive dorsal root ganglion cells. Eur J Neurosci 5:154-161.
21. Hannibal J, Mikkelsen JD, Clausen H, Holst JJ, Wulff BS, Fahrenkrug J. 1995. Gene expression of pituitary adenylate cyclase-activating polypeptide (PACAP) in the rat hypothalamus. Regul Peptides 55:133-148.
22. Hannibal J, Jessop DS, Fahrenkrug J, Harbuz MS, Larsen PJ. 1999. PACAP gene expression in neurons of the rat hypothalamo-pituitary-adrenocortical axis is induced by endotoxin and interleukin-1B. Neuroendocrinology 70:73-82.
23. Ho N, Koziol JA, Parsons CL. 1997. Epidemiology of interstitial cystitis. In: Sant GR, editor. Interstitial cystitis. Philadelphia: Lippincott-Raven Publishers, p 9-16.
24. Ishizuka O, Alm P, Larsson B, A. M, Andersson K-E. 1995. Facilitatory effect of pituitary adenylate cyclase-activating polypeptide on micturition in normal conscious rats. Neuroscience 66:1009-1014.
25. Jennings LJ, Vizzard MA. 1999. Cyclophosphamide-induced inflammation of the urinary bladder alters electrical properties of small diameter afferent neurons from dorsal root ganglia. FASEB J 13:A57.
26. Johansson SL, Ogawa K, Fall M. 1997. The pathology of interstitial cystitis. In: Sant GR, editor. Interstitial cystitis. Philadelphia: Lippincott-Raven Publishers, p 143-152.
27. Keast JR, de Groat WC. 1992. Segmental distribution and peptide content of primary afferent neurons innervating the urogenital organs and colon of male rats. J Comp Neurol 319:615-623.
28. Korsching S. 1993. The neurotrophic factor concept: a reexamination. J Neurosci 13:2739-2748.
29. Lantéri-Minet M, Bon K, de Pommery J, Michiels JF, Menétrey D. 1995. Cyclophosphamide cystitis as a model of visceral pain in rats: model elaboration and spinal structures involves as revealed by the expression of c-Fos and Krox-24 proteins. Exp Brain Res 105:220-232.
30. Larsen JO, Hannibal J, Knudsen SM, Fahrenkrug J. 1997. Expression of pituitary adenylate cyclase-activating polypeptide (PACAP) in the mesencephalic trigeminal nucleus of the rat after transection of the masseteric nerve. Brain Res Mol Brain Res 46:109-117.
31. Lecci A, Giulani S, Santicioli P, Maggi CA. 1994. Involvement of spinal tachykinin NK1 and NK2 receptors in detrusor hyperreflexia during chemical cystitis in anaesthetized rats. Eur J Pharmacol 259:129-135.
32. Levine LA, Richie JP. 1989. Urological complications of Cyclophosphamide. J Urol 141:1063-1069.
33. Maggi CA, Lecci A, Santicioli P, Del Biance E, Giuliani S. 1992. Cyclophosphamide cystitis in rats: involvement of capsaicin-sensitive primary afferents. J Autonom Nerv Syst 38:201-208.
34. Masuo Y, Suzuki N, Matsumoto H, Tokito F, Matsumoto Y, Tsuda M, Fujino M. 1993. Regional distribution of pituitary adenylate cyclase-activating polypeptide (PACAP) in the rat central nervous system as determined by sandwich-enzyme immunoassay. Brain Res 602:57-63.
35. McMahon SB. 1996. NGF as a mediator of inflammatory pain. Phil Trans R Soc London Biol Sci 351:431-440.
36. Meller ST, Gebhart GF. 1993. Nitric oxide (NO) and nociceptive processing in the spinal cord. Pain 52:127-136.
37. Moller K, Zhang Y-Z, Hakanson R, Luts A, Sjolund B, Uddman R, Sundler F. 1993. Pituitary adenylate cyclase-activating peptide is a sensory neuropeptide: immunocytochemical and immunochemical evidence. Neuroscience 57:725-732.
38. Moller K, Reimer M, Ekblad E, Hannibal J, Fahrenkrug J, Kanje M, Sundler F. 1997, The effects of axotomy and preganglionic denervation on the expression of pituitary adenylate cyclase-activating peptide (PACAP), galanin and PACAP type 1 receptors in the rat superior cervical ganglion. Brain Res 775:166-182.
39. Morgan C, Nadelhaft I, de Groat WC. 1981. The distribution of visceral primary afferents from the pelvic nerve within Lissauer's tract and the spinal gray matter and its relationship to the sacral parasympathetic nucleus. J Comp Neurol 201:415-440.
40. Pelissier N, Doone G, Boyle MM, Vizzard MA. 1999. Changes in growth associated protein (GAP-43), calcitonin gene-related peptide (CGRP) and pituitary adenylate cyclase-activating polypeptide (PACAP38) in L6-S1 spinal cord and dorsal root ganglia (DRG) following cyclophosphamide (CYP)-induced cystitis. Soc Neurosci Abstr 25:1686.
41. Perl ER, Kumuzawa T, Lynn B, Kenins P. 1974. Sensitization of high threshold receptors with unmyelinated (C) afferent fibres. In: Iggo A, Ilynksy I, editors. Somatosensory and visceral receptor mechanisms. Progress in brain research. Amsterdam: Elsevier, p 263-278.
42. Petrone RL, Agha AH, Roy JB, Hurst RE. 1995. Urodynamic findings in patients with interstitial cystitis. J Urol 153:290A.
43. Reichardt LF, Farinas I. 1997. Neurotrophic factors and their receptors: roles in neuronal development and function. In: Cowan, WM, Jessel TM, Zipursky SL, editors. Molecular and cellular approaches to neural development. New York: Oxford University Press, p 220-263.
44. Ruda MA, Iadarola MJ, Cohen LV, Yound WS II. 1988. In situ hybridization, histochemistry and immunocytochemistry reveal an increase in spinal dynorphin biosynthesis in a rat model of peripheral inflammation and hyperalgesia. Proc Natl Acad Sci USA 85:622-626.
45. Sengupta JN, Gebhart GF. 1994. Mechanosensitive properties of pelvic nerve afferent fibers innervating the urinary bladder of the rat. J Neurophysiol 72:2420-2430.
46. Smith GD, Harmar AJ, McQueen DS, Seckl JR. 1992. Increase in substance P and CGRP, but not somatostatin content of innervating dorsal root ganglia in adjuvant monoarthritis in the rat. Neurosci Lett 137:257-260.
47. Steers WD, de Groat WC. 1988. Effect of bladder outlet obstruction on micturition reflex pathways in the rat. J Urol 140:864-871.
48. Steers WD, Ciambotti J, Etzel B, Erdman S, de Groat WC. 1991a. Alterations in afferent pathways from the urinary bladder of the rat in response to partial urethral obstruction. J Comp Neurol 310:1-10.
49. Steers WD, Kolbeck S, Creedon D, Tuttle JB. 1991b. Nerve growth factor in the urinary bladder of the adult regulates neuronal form and function. J Clin Invest 88:1709-1715.
50. Steers WD, Creedon DJ, Tuttle JB. 1996. Immunity to nerve growth factor prevents afferent plasticity following urinary bladder hypertrophy. J Urol 155:379-385.
51. Stillwell TJ, Benson RC. 1988. Cyclophosphamide-induced cystitis. A review of 100 patients. Cancer 61:451-457.
52. Su HC, Polak JM, Mulderry PK, Ghatei MA, Gibson SJ, Terenghi G, Morrison JFB, Ballesta J, Bloom SR. 1986. Calcitonin gene-related peptide immunoreactivity in afferent neurons supplying the urinary tract: combined retrograde tracing and immunohistochemistry. Neuroscience 18:727-747.
53. Sundler F, Ekblad E, Hannibal J, Moller K, Zhang YZ, Mulder H, Elsas T, Grunditz T, Danielsen N, Fahrenkrug J, Uddman R. 1996. Pituitary adenylate cyclase-activating peptide in sensory and autonomic ganglia: localization and regulation. Ann NY Acad Sci 805:410-426.
54. Tuttle JB, Steers WD, Albo M, Nataluk E. 1994. Neural input regulates tissue NGF and growth of the adult rat urinary bladder. J Autonom Nerv Syst 49:147-158.
55. Vantini G, Skaper SD. 1992. Neurotrophic factors: from physiology to pharmacology. Pharmacol Res 26:1-15.
56. Vizzard MA. 1999a. Changes in neurotrophic factor mRNA and NGF protein following urinary bladder dysfunction. Exp Neurol (in press).
57. Vizzard MA. 1999b. Increased expression of spinal Fos protein in lower urinary tract pathways induced by bladder distension following chronic cystitis. Am J Physiol (in press).
58. Vizzard MA, Boyle MM. 1999. Increased expression of growth associated protein (GAP-43) in lower urinary tract pathways following cyclophosphamide (CYP)-induced urinary bladder inflammation. Brain Res 844: 174-187.
59. Vizzard MA, de Groat WC. 1996. Increased expression of neuronal nitric oxide synthase (NOS) in bladder afferent pathways following chronic bladder irritation. J Comp Neurol 370:191-202.
60. Vizzard MA, Erdman SL, de Groat WC. 1993a. The effect of rhizotomy on NADPH diaphorase staining in the lumbar spinal cord of the rat. Brain Res 607:349-353.
61. Vizzard MA, Erdman SL, de Groat WC. 1993b. Localization of NADPH-diaphorase in bladder afferent and postganglionic efferent neurons of the rat. J Autonom Nerv Syst 44:85-90.
62. Vizzard MA, Erdman SL, Erickson VL, Stewart RJ, Roppolo JR, de Groat WC. 1994. Localization of NADPH-diaphorase in the lumbosacral spinal cord and dorsal root ganglia of the cat. J Comp Neurol 339:62-75.
63. Wakabayashi Y, Maeda T. Kwok YN. 1996. Increase in p75 immunoreactivity in rat urinary bladder following inflammation. Neuroreport 7: 1141-1144.
64. Wang Z-Y, Alm P, Hakanson R. 1996. PACAP occurs in sensory nerve fibers and participates in ocular inflammation in the rabbit. Ann NY Acad Sci 805:779-783.
65. Watson NA, Notley RG. 1973. Urological complications of cyclophosphamide. Br J Urol 45:606.
66. Yoshimura N. 1999. Bladder afferent pathways and spinal cord injury: possible mechanisms inducing hyperreflexia of the urinary bladder. Progr Neurobiol 57:583-606.
67. Yoshimura N, de Groat WC. 1999. Increased excitability of afferent neurons innervating rat urinary bladder following chronic bladder inflammation. J Neurosci 19:4644-4653.
68. Zhang Q, Shi T-J, Ji R-R, Zhang Y-T, Sundler F, Hannibal J, Fahrenkrug J, Hökfelt T. 1995. Expression of pituitary adenylate cyclase-activating polypeptide in dorsal root ganglia following axotomy: time course and coexistence. Brain Res 705:149-158.
69. Zhang Y-Z, Hannibal J, Zhao Q, Moller K, Danielsen N, Fahrenkrug J, Sundler F. 1996. Pituitary adenylate cyclase-activating peptide expression in the rat dorsal root ganglia: up-regulation after peripheral nerve injury. Neuroscience 74:1099-1110.
70. Zhang YZ, Danielsen N, Sundler F, Mulder H. 1998. Pituitary adenylate cyclase-activating peptide is upregulated in sensory neurons by inflammation. Neuroreport 9:2833-2836.