Rational modification of protein stability by the mutation of charged surface residues

Biochemistry

Volumn 39, Issue 5, 2000, Pages 872-879

  Spector, Shari ^a,b   Wang, Minghui ^a   Carp, Stefan A ^b   Robblee, James ^c   Hendsch, Zachary S ^b   Fairman, Robert ^c   Tidor, Bruce ^b   Raleigh, Daniel P ^a  

^a STONY BROOK UNIVERSITY   (United States)

^b MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^c HAVERFORD COLLEGE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 AMINOADIPIC ACID; ARGININE; MEMBRANE PROTEIN; NORLEUCINE; PROTEIN;

AMINO ACID SUBSTITUTION; ARTICLE; CALCULATION; CATALYSIS; CONTROLLED STUDY; ELECTRICITY; MUTATION; NONHUMAN; PEPTIDE SYNTHESIS; PRIORITY JOURNAL; PROTEIN MODIFICATION; PROTEIN STABILITY; SURFACE CHARGE;

ACETYLTRANSFERASES; AMINO ACIDS; ARGININE; ASPARTIC ACID; BACILLUS STEAROTHERMOPHILUS; BINDING SITES; DIHYDROLIPOYLLYSINE-RESIDUE ACETYLTRANSFERASE; ELECTROSTATICS; ENZYME STABILITY; LYSINE; MUTAGENESIS, SITE-DIRECTED; NORLEUCINE; PEPTIDE FRAGMENTS; PROTEIN DENATURATION; PROTEIN STRUCTURE, TERTIARY; PYRUVATE DEHYDROGENASE COMPLEX; SURFACE PROPERTIES; THERMODYNAMICS;

EID: 0034620528     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi992091m     Document Type: Article

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