A rat nasal epithelial model for predicting upper respiratory tract toxicity: In vivo-in vitro correlations

Toxicology

Volumn 145, Issue 1, 2000, Pages 39-49

  Kilgour, J D ^a   Simpson, S A ^a   Alexander, D J ^b   Reed, C J ^a  

^a LIVERPOOL JOHN MOORES UNIVERSITY   (United Kingdom)

^b GLAXOSMITHKLINE   (United Kingdom)

Author keywords

3 Methylindole; Acetic acid; In vitro toxicity; Nasal cavity; Olfactory epithelium; Respiratory epithelium; Sodium carbonate; Titanium dioxide

Indexed keywords

ACETIC ACID; ADENOSINE TRIPHOSPHATE; SKATOLE; SODIUM CARBONATE; TITANIUM DIOXIDE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; IN VITRO STUDY; MALE; METABOLIC ACTIVATION; MODEL; NONHUMAN; NOSE MUCOSA; POTASSIUM CELL LEVEL; PRIORITY JOURNAL; RAT; RESPIRATORY TRACT DISEASE; TOXICITY TESTING;

ACETIC ACID; ADENOSINE TRIPHOSPHATE; ANIMALS; CARBONATES; DOSE-RESPONSE RELATIONSHIP, DRUG; MALE; NASAL MUCOSA; POTASSIUM; RATS; RATS, WISTAR; SKATOLE; TITANIUM;

EID: 0034616160     PISSN: 0300483X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0300-483X(99)00180-8     Document Type: Article

References (28)

1. Bascom, R. Kesavanathan, J., Fitzgerald, T.K., Cheng, K.H., and Swift, D.L. (1995). Sidestream tobacco smoke exposure acutely alters human nasal mucociliary clearance. Environ. Health Perspect. 103, 1026-1030.
2. Bogdanffy M.S., Dreef-van der Meulen H.C., Beems R.B., Feron V.J., Casceiri T.C., Tyler T.R., Vinegar M.B., Rickard R.W. Chronic toxicity and oncogenicity inhalation study with vinyl acetate in the rat and mouse. Fundamen. Appl. Toxicol. 23:1994;215-229.
3. Bond J.A. Factors modifying the disposition of inhaled organic compounds. McClellan R.O., Henderson R.F. Concepts in Inhalation Toxicology. 1989;251-278 Hemisphere, New York.
4. Brandt I., Brittebo E.B., Feil V.J., Bakke J.E. Irreversible binding and toxicity of the herbicide dichlobenil (2,6-dichlorobenzonitrile) in the olfactory mucosa of mice. Toxicol. Appl. Pharmacol. 103:1990;491-501.
5. Bray T.M., Emmerson K.S. Putative mechanisms of toxicity of 3-methylindole: from free radical to pneumotoxicosis. Ann. Rev. Pharmacol. Toxicol. 34:1994;91-115.
6. Busch R.M., McDonald K.E., Briant J.K., Morris J.E., Graham T.M. Pathological effects in rodents exposed to sodium combustion products. Environ. Res. 31:1983;138-147.
7. Dahl A.R., Hadley W.M. Nasal cavity enzymes involved in xenobiotic metabolism: effects on the toxicity of inhalants. Crit. Rev. Toxicol. 21:1991;345-372.
8. Gaskell B.A., Hext P.M., Pigott G.H., Hodge M.C.H., Tinston D.J. Olfactory and hepatic changes following inhalation of 3-trifluoromethyl pyridine in rats. Toxicology. 50:1988;57-68.
9. Hart S.E., Cartun R.W., Wyand D.S., Khairallah E.A., Cohen S.D. Immunohistochemical localization of acetaminophen in target tissues of the cd-1 mouse - correspondence of covalent binding with toxicity. Fundamen. Appl. Toxicol. 24:1995;260-274.
10. Heinrich U., Fuhst R., Rittinghausen S., Creutzenberg O., Bellmann B., Koch W., Levsen K. Chronic inhalation exposure of Wistar rats and two different strains of mice to diesel engine exhaust, carbon black, and titanium dioxide. Inhalation Toxicol. 7:1995;533-556.
11. Johansson, S.L., 1981. Carcinogenicity of analgesics: long-term treatment of Sprague-Dawley rats with phenacetin, phenazone, caffeine and paracetamol (acetamidophen). Int. J. Cancer 27, 521-529.
12. Johnson N.F., Hotchkiss J.A., Harkema J.R., Henderson R.F. Proliferative responses of rat nasal epithelia to ozone. Toxicol. Appl. Pharmacol. 103:1990;143-155.
13. Keenan C.M., Kelly D.P., Bogdanffy M.S. Degeneration and recovery of rat olfactory epithelium following inhalation of dibasic esters. Fundamen. Appl. Toxicol. 15:1990;381-393.
14. Kilgour J.D., Alexander D.J., Reed C.J. Development of an in vitro rat nasal epithelial model for predicting upper respiratory tract toxicity. Toxicol. Methods. 8:1998;1-17.
15. Kilgour J.D., Alexander D.J., Reed C.J. Maintenance of xenobiotic biotransformation in an in vitro model of the rat nasal cavity. In Vitro Mol. Toxicol. 11:1998;255-264.
16. 2) by inhalation for two years. Toxicol. Appl. Pharmacol. 79:1985;179-192.
17. McMahon T.A., Brain J.D., Lemott S.R. Species differences in airway deposition. Walton W.H. Inhaled Particles IV. 1977;23-32 Pergamon, New York.
18. Morgan K.T. A brief review of formaldehyde carcinogenesis in relation to rat nasal pathology and human health risk assessment. Toxicol. Pathol. 25:1997;291-307.
19. Morgan, K.T., Gross, E.A., Joyner, D.R., Ishmael, J., Thake, D., 1997. Proliferative nasal lesions induced in rats by alachlor, acetochlor and butachlor originate in specific regions of the olfactory mucosa. Toxicologist, 112.
20. Peele D.B., Allison S.D., Bolon B., Prah J.D., Jensen K.F., Morgan K.T. Functional deficits produced by 3-methylindole-induced olfactory mucosal damage revealed by a simple olfactory learning task. Toxicol. Appl. Pharmacol. 107:1991;191-202.
21. Reed C.J. Drug metabolism in the nasal cavity: relevance to toxicology. Drug Met. Rev. 25:1993;173-205.
22. Reed C.J., Gaskell B.A., Banger K.K., Lock E.A. Olfactory toxicity of methyl iodide in the rat. Arch. Toxicol. 70:1995;51-56.
23. Thornton-Manning J.R., Dahl A.R. Metabolic capacity of nasal tissue: interspecies comparisons of xenobiotic-metabolizing enzymes. Mut. Res. 380:1997;43-59.
24. Thornton-Manning J.R., Ruangyuttikarn W., Gonzalez F.J., Yost G.S. Metabolic activation of the pneumotoxin, 3-methylindole, by vaccinia-expressed cytochrome P450s. Biochem. Biophys. Res. Commun. 181:1991;100-107.
25. Thornton-Manning J.R., Appleton M.L., Gonzalez F.J., Yost G.S. Metabolism of 3-methylindole by vaccinia-expressed P450 enzymes: correlation of 3-methyleneindolenine formation and protein binding. J. Pharmacol. Exp. Ther. 276:1996;21-29.
26. Turk M.A.M., Henk W.G., Flory W. 3-Methylindole-induced nasal mucosal damage in mice. Vet. Pathol. 24:1987;400-403.
27. Young J.T. Histopathological examination of the rat nasal cavity. Fundamen. Appl. Toxicol. 1:1981;309-312.
28. Zissu D. Histopathological changes in the respiratory tract of mice exposed to ten families of airborne chemicals. J. Appl. Toxicol. 15:1995;207-213.