-
1
-
-
0345516901
-
The metabolism and toxicity of xenobiotics in a primary culture system of postnatal rat hepatocytes
-
E.J. Rauckman and G.M. Padilla (eds.) Academic Press: London
-
ACOSTA, D., MITCHELL, D.B., SORENSEN, E.B.M., and BRUCKNER, J.V. (1987). The metabolism and toxicity of xenobiotics in a primary culture system of postnatal rat hepatocytes, in: The isolated hepatocyte: Use in Toxicology and Xenobiotic Biotransformations. E.J. Rauckman and G.M. Padilla (eds.) Academic Press: London, pp. 189-214.
-
(1987)
The Isolated Hepatocyte: Use in Toxicology and Xenobiotic Biotransformations
, pp. 189-214
-
-
Acosta, D.1
Mitchell, D.B.2
Sorensen, E.B.M.3
Bruckner, J.V.4
-
2
-
-
0027158593
-
Maintenance and induction in cocultured rat hepatocytes of components of the cytochrome P450-mediated monooxygenase
-
AKRAWI, M., ROGIERS, V., VANDENBERGHE, Y., et al. (1993). Maintenance and induction in cocultured rat hepatocytes of components of the cytochrome P450-mediated monooxygenase. Biochem. Pharmacol. 45, 1583-1591.
-
(1993)
Biochem. Pharmacol.
, vol.45
, pp. 1583-1591
-
-
Akrawi, M.1
Rogiers, V.2
Vandenberghe, Y.3
-
3
-
-
0027499860
-
The characterization of glutathione S-transferases from rat olfactory epithelium
-
BANGER, K.K., LOCK, E.A., and REED, C.J. (1993). The characterization of glutathione S-transferases from rat olfactory epithelium. Biochem. J. 290, 199-204.
-
(1993)
Biochem. J.
, vol.290
, pp. 199-204
-
-
Banger, K.K.1
Lock, E.A.2
Reed, C.J.3
-
4
-
-
0023280283
-
Biochemical quantitation and histochemical localisation of carboxylesterase in the nasal passages of the Fischer 344 rat and B6C3F1 mouse
-
BOGDANFFY, M.S., RANDALL, H.W., and MORGAN, K.T. (1987). Biochemical quantitation and histochemical localisation of carboxylesterase in the nasal passages of the Fischer 344 rat and B6C3F1 mouse. Toxicol. Appl. Pharmacol. 88, 183-194.
-
(1987)
Toxicol. Appl. Pharmacol.
, vol.88
, pp. 183-194
-
-
Bogdanffy, M.S.1
Randall, H.W.2
Morgan, K.T.3
-
5
-
-
0026080934
-
Metabolism of dibasic esters by rat nasal mucosal carboxylesterase
-
BOGDANFFY, M.S., KEE, C.R., HINCHMAN, C.A., and TRELA, B.A. (1991). Metabolism of dibasic esters by rat nasal mucosal carboxylesterase. Drug Met. Disp. 19, 124-129.
-
(1991)
Drug Met. Disp.
, vol.19
, pp. 124-129
-
-
Bogdanffy, M.S.1
Kee, C.R.2
Hinchman, C.A.3
Trela, B.A.4
-
6
-
-
0020644584
-
Some biotransformation enzymes responsible for polycyclic aromatic hydrocarbon metabolism in rat nasal turbinates: Effects on enzyme activities of in vitro modifiers and intraperitoneal and inhalation exposure of rats to inducing agents
-
BOND, J.A. (1983). Some biotransformation enzymes responsible for polycyclic aromatic hydrocarbon metabolism in rat nasal turbinates: Effects on enzyme activities of in vitro modifiers and intraperitoneal and inhalation exposure of rats to inducing agents. Cancer Res. 43, 4805-4811.
-
(1983)
Cancer Res.
, vol.43
, pp. 4805-4811
-
-
Bond, J.A.1
-
7
-
-
0023130756
-
Metabolic activation of phenacetin in rat nasal mucosa: Dose-dependent binding to the glands of Bowman
-
BRITTEBO, E.B. (1987). Metabolic activation of phenacetin in rat nasal mucosa: Dose-dependent binding to the glands of Bowman. Cancer Res. 47, 1449-1456.
-
(1987)
Cancer Res.
, vol.47
, pp. 1449-1456
-
-
Brittebo, E.B.1
-
8
-
-
0019806732
-
Formation of tissue-bound N'nitrosonornicotine metabolites by the target tissues of Sprague-Dawley and Fisher rats
-
BRITTEBO, E.B., and TJALVE, H. (1981). Formation of tissue-bound N'nitrosonornicotine metabolites by the target tissues of Sprague-Dawley and Fisher rats. Carcinogenesis 2, 959-963.
-
(1981)
Carcinogenesis
, vol.2
, pp. 959-963
-
-
Brittebo, E.B.1
Tjalve, H.2
-
9
-
-
0020042933
-
Tissue-specificity of N-nitrosodibutylamine metabolism in Sprague-Dawley rats
-
BRITTEBO, E.B., and TJALVE, H. (1982). Tissue-specificity of N-nitrosodibutylamine metabolism in Sprague-Dawley rats. Chem.-Biol. Interact. 38, 231-242.
-
(1982)
Chem.-Biol. Interact.
, vol.38
, pp. 231-242
-
-
Brittebo, E.B.1
Tjalve, H.2
-
10
-
-
0021340976
-
Metabolism of chlorobenzene in the mucosa of the murine respiratory tract
-
BRITTEBO, E. and BRANDT, I. (1984). Metabolism of chlorobenzene in the mucosa of the murine respiratory tract. Lung 162, 79-88.
-
(1984)
Lung
, vol.162
, pp. 79-88
-
-
Brittebo, E.1
Brandt, I.2
-
11
-
-
0019430560
-
Sites of metabolism of N-nitrosodiethylamine in mice
-
BRITTEBO, E.B., LOFBERG, B., and TJALVE, H. (1981a). Sites of metabolism of N-nitrosodiethylamine in mice. Chem.-Biol. Interact. 34, 209-221.
-
(1981)
Chem.-Biol. Interact.
, vol.34
, pp. 209-221
-
-
Brittebo, E.B.1
Lofberg, B.2
Tjalve, H.3
-
12
-
-
0019780786
-
Extrahepatic sites of metabolism of N-nitrosopyrrolidine in mice and rats
-
BRITTEBO, E.B., LOFBERG, B., and TJALVE, H. (1981b). Extrahepatic sites of metabolism of N-nitrosopyrrolidine in mice and rats. Xenobiotica 11, 619-625.
-
(1981)
Xenobiotica
, vol.11
, pp. 619-625
-
-
Brittebo, E.B.1
Lofberg, B.2
Tjalve, H.3
-
13
-
-
0026336673
-
Proliferative and neoplastic lesions in the rodent nasal cavity
-
BROWN, H.R., MONTICELLO, T.M., MARONPOT, R.R., et al. (1991). Proliferative and neoplastic lesions in the rodent nasal cavity. Toxicol. Pathol. 19, 358-372.
-
(1991)
Toxicol. Pathol.
, vol.19
, pp. 358-372
-
-
Brown, H.R.1
Monticello, T.M.2
Maronpot, R.R.3
-
14
-
-
84889192568
-
The olfactory toxicity of methyl iodide. In vitro mechanistic studies in a rat nasal epithelial model
-
CHAMBERLAIN, M.P., LOCK, E.A., and REED, C.J. (1997). The olfactory toxicity of methyl iodide. In vitro mechanistic studies in a rat nasal epithelial model. Hum. Exp. Toxicol. 16, 419.
-
(1997)
Hum. Exp. Toxicol.
, vol.16
, pp. 419
-
-
Chamberlain, M.P.1
Lock, E.A.2
Reed, C.J.3
-
15
-
-
0022376374
-
Activities of several phase I and Phase II xenobiotic biotransformation enzymes in culutred hepatocytes from male and female rats
-
CROCI, T., and WILLIAMS, G.M. (1985). Activities of several phase I and Phase II xenobiotic biotransformation enzymes in culutred hepatocytes from male and female rats. Biochem. Pharmacol. 34, 3029-3035.
-
(1985)
Biochem. Pharmacol.
, vol.34
, pp. 3029-3035
-
-
Croci, T.1
Williams, G.M.2
-
16
-
-
0025838093
-
Nasal cavity enzymes involved in xenobiotic metabolism: Effects on the toxicity of inhalants
-
DAHL, A.R., and HADLEY, W.M. (1991). Nasal cavity enzymes involved in xenobiotic metabolism: Effects on the toxicity of inhalants. CRC Crit. Rev. Toxicol. 21, 345-372.
-
(1991)
CRC Crit. Rev. Toxicol.
, vol.21
, pp. 345-372
-
-
Dahl, A.R.1
Hadley, W.M.2
-
17
-
-
0023255857
-
Carboxylesterases in the respiratory tracts of rabbits, rats and Syrian hamsters
-
DAHL, A.R., MILLER, S.C., and PETRIDOU-FISCHER, J. (1987). Carboxylesterases in the respiratory tracts of rabbits, rats and Syrian hamsters. Toxicol. Lett. 36, 129-136.
-
(1987)
Toxicol. Lett.
, vol.36
, pp. 129-136
-
-
Dahl, A.R.1
Miller, S.C.2
Petridou-Fischer, J.3
-
18
-
-
0029023892
-
Effect of ethanol on glutathione S-transferase expression in cocultured rat hepatocytes
-
DEBAST, G., COECKE, S., AKRAWI, M., et al. (1995). Effect of ethanol on glutathione S-transferase expression in cocultured rat hepatocytes. Toxicol. In Vitro 9, 467-471.
-
(1995)
Toxicol. In Vitro
, vol.9
, pp. 467-471
-
-
Debast, G.1
Coecke, S.2
Akrawi, M.3
-
19
-
-
0023812216
-
Purification and characterization of two unique forms of cytochrome P450 from rabbit nasal microsomes
-
DING, X., and COON, M.J. (1988). Purification and characterization of two unique forms of cytochrome P450 from rabbit nasal microsomes. Biochemistry 27, 8330-8337.
-
(1988)
Biochemistry
, vol.27
, pp. 8330-8337
-
-
Ding, X.1
Coon, M.J.2
-
20
-
-
0025870255
-
Cocultures of hepatocytes with epithelial-like cell lines - Expression of drug biotransformation activities by hepatocytes
-
DONATO, M.T., CASTELL, J.V., and GOMEZLE-CHON, M.J. (1991). Cocultures of hepatocytes with epithelial-like cell lines - expression of drug biotransformation activities by hepatocytes. Cell Biol. Toxicol. 7, 1-15.
-
(1991)
Cell Biol. Toxicol.
, vol.7
, pp. 1-15
-
-
Donato, M.T.1
Castell, J.V.2
Gomezle-Chon, M.J.3
-
21
-
-
0020029661
-
Metal induction of heme oxygenase without concurrent degradation of cytochrome P-450. Protective effects of compound SKF-525A on the heme protein
-
DRUMMOND, G.S., ROSENBERG, D.W., and KAPPAS, A.H. (1982). Metal induction of heme oxygenase without concurrent degradation of cytochrome P-450. Protective effects of compound SKF-525A on the heme protein. Biochem. J. 202, 59-66.
-
(1982)
Biochem. J.
, vol.202
, pp. 59-66
-
-
Drummond, G.S.1
Rosenberg, D.W.2
Kappas, A.H.3
-
22
-
-
0028144313
-
The effects of ozone exposure on lactate dehydrogenase release from human and primate respiratory epithelian cells
-
DUMLER, K., HANLEY, Q.S., BAKER, C., LUCHTEL, D.L., ALTMAN, L.C., and KOENIG, J.Q. (1994). The effects of ozone exposure on lactate dehydrogenase release from human and primate respiratory epithelian cells. Toxicol. Lett. 70, 203-209.
-
(1994)
Toxicol. Lett.
, vol.70
, pp. 203-209
-
-
Dumler, K.1
Hanley, Q.S.2
Baker, C.3
Luchtel, D.L.4
Altman, L.C.5
Koenig, J.Q.6
-
23
-
-
0025775790
-
Metabolic activation of the herbicide dichlobenil in the olfactory mucosa
-
ERIKSSON, C., and BRITTEBO, E.B. (1991). Metabolic activation of the herbicide dichlobenil in the olfactory mucosa. Chem.-Biol. Interact. 79, 165-177.
-
(1991)
Chem.-Biol. Interact.
, vol.79
, pp. 165-177
-
-
Eriksson, C.1
Brittebo, E.B.2
-
24
-
-
0021341031
-
Regulation of heme metabolism and cytochrome P450 levels in primary culture of rat hepatocytes in a defined medium
-
EVERTS, R.P., MARSDEN, E., and THORGEVISSON, S.S. (1984). Regulation of heme metabolism and cytochrome P450 levels in primary culture of rat hepatocytes in a defined medium. Biochem. Pharmacol. 33, 565-571.
-
(1984)
Biochem. Pharmacol.
, vol.33
, pp. 565-571
-
-
Everts, R.P.1
Marsden, E.2
Thorgevisson, S.S.3
-
25
-
-
0025679098
-
Influence of hormones and drugs on glutathione S-transferase levels in primary culture of adult rat hepatocytes
-
GEBHARDT, R., FITZKE, H., FAUSEL, M., EISENMANNTAPPE, I., and MECKE, D. (1990). Influence of hormones and drugs on glutathione S-transferase levels in primary culture of adult rat hepatocytes. Cell Biol. Toxicol. 6, 365-378.
-
(1990)
Cell Biol. Toxicol.
, vol.6
, pp. 365-378
-
-
Gebhardt, R.1
Fitzke, H.2
Fausel, M.3
Eisenmanntappe, I.4
Mecke, D.5
-
26
-
-
0028373342
-
Effects of P450 inhibition and induction on the olfactory toxicity of β,β′-iminodipropionitrile (IDPN) in the rat
-
GENTER, M.B., DEAMER, N.J., CAO, Y., and LEVI, P.E. (1994). Effects of P450 inhibition and induction on the olfactory toxicity of β,β′-iminodipropionitrile (IDPN) in the rat. J. Biochem. Toxicol. 9, 31-39.
-
(1994)
J. Biochem. Toxicol.
, vol.9
, pp. 31-39
-
-
Genter, M.B.1
Deamer, N.J.2
Cao, Y.3
Levi, P.E.4
-
27
-
-
0030602897
-
Effects of metyrapone on expression of CYPs 2C11, 3A2, and other 3A genes in rat hepatocytes cultured on Matrigel
-
GOODWIN, B., LIDDLE, C., MURRAY, M., TAPRIER, M., ROONEY, T., and FARRELL, G.C. (1996). Effects of metyrapone on expression of CYPs 2C11, 3A2, and other 3A genes in rat hepatocytes cultured on Matrigel. Biochem. Pharmacol. 52, 219-227.
-
(1996)
Biochem. Pharmacol.
, vol.52
, pp. 219-227
-
-
Goodwin, B.1
Liddle, C.2
Murray, M.3
Taprier, M.4
Rooney, T.5
Farrell, G.C.6
-
28
-
-
0022391903
-
Maintenance of cytochrome P-450 in cultured adult human hepatocytes
-
GUILLOUZO, A., BEAUNE, P., GASCOIN, M.-N., et al. (1985). Maintenance of cytochrome P-450 in cultured adult human hepatocytes. Biochem. Pharmacol. 34, 2991-2995.
-
(1985)
Biochem. Pharmacol.
, vol.34
, pp. 2991-2995
-
-
Guillouzo, A.1
Beaune, P.2
Gascoin, M.-N.3
-
29
-
-
0017686599
-
Drug metabolism in adult rat hepatocytes in primary monolayer culture
-
GUZELIAN, P.S., BISSEL, M.D., AND MEYER, U.A. (1977). Drug metabolism in adult rat hepatocytes in primary monolayer culture. Gastroenterology 72,1232-1239.
-
(1977)
Gastroenterology
, vol.72
, pp. 1232-1239
-
-
Guzelian, P.S.1
Bissel, M.D.2
Meyer, U.A.3
-
30
-
-
0026577791
-
The accumulation and metabolism of 3-trifluoromethyl-pyridine by rat olfactory and hepatic tissues
-
HEXT, P.M., and LOCK, E.A. (1992). The accumulation and metabolism of 3-trifluoromethyl-pyridine by rat olfactory and hepatic tissues. Toxicology 72, 61-75.
-
(1992)
Toxicology
, vol.72
, pp. 61-75
-
-
Hext, P.M.1
Lock, E.A.2
-
31
-
-
0016275313
-
Glutathione S-transferases. The first enzymatic step in mercapturic acid formation
-
HABIG, W.H., PABST, M.J., and JAKOBY, W.B. (1974). Glutathione S-transferases. The first enzymatic step in mercapturic acid formation. J. Biol. Chem. 249, 7130-7139.
-
(1974)
J. Biol. Chem.
, vol.249
, pp. 7130-7139
-
-
Habig, W.H.1
Pabst, M.J.2
Jakoby, W.B.3
-
33
-
-
0027506368
-
Maintenance of liver-specific functions in cultured hepatocytes in different media
-
KHAN, S., PAXTON, J., ROBERTS, P., and SKETT, P. (1992). Maintenance of liver-specific functions in cultured hepatocytes in different media. Biochem. Soc. Trans. 21, 70S.
-
(1992)
Biochem. Soc. Trans.
, vol.21
-
-
Khan, S.1
Paxton, J.2
Roberts, P.3
Skett, P.4
-
34
-
-
0343993329
-
Development of an in vitro nasal epithelial model to predict respiratory tract toxicity
-
KILGOUR, J.D., ALEXANDER, D.J., and REED, C.J. (1996). Development of an in vitro nasal epithelial model to predict respiratory tract toxicity. Hum. Exp. Toxicol. 15, 148.
-
(1996)
Hum. Exp. Toxicol.
, vol.15
, pp. 148
-
-
Kilgour, J.D.1
Alexander, D.J.2
Reed, C.J.3
-
35
-
-
0032406217
-
Development of an in vitro rat nasal epithelial model for preicting upper respiratory tract toxicity
-
in press
-
KILGOUR, J.D., ALEXANDER, D.J., and REED, C.J. (1998). Development of an in vitro rat nasal epithelial model for preicting upper respiratory tract toxicity. Tox. Meth. (in press).
-
(1998)
Tox. Meth.
-
-
Kilgour, J.D.1
Alexander, D.J.2
Reed, C.J.3
-
36
-
-
0027460346
-
Expression of multiple forms of cytochrome P450 mRNAs in primary cultures of rat hepatocytes maintained on Matrigel
-
KOCAREK, T.A., SCHUETZ, E.G., and GUZELIAN, P.S. (1993). Expression of multiple forms of cytochrome P450 mRNAs in primary cultures of rat hepatocytes maintained on Matrigel. Mol. Pharmacol. 43, 328-334.
-
(1993)
Mol. Pharmacol.
, vol.43
, pp. 328-334
-
-
Kocarek, T.A.1
Schuetz, E.G.2
Guzelian, P.S.3
-
37
-
-
0027453767
-
Cytotoxicity and DNA-protein crosslink formation in rat nasal tissues exposed to vinyl acetate are carboxylesterase-mediated
-
KUYKENDALL, J.R., TAYLOR, M.L., and BOGDANFFY, M.S. (1993). Cytotoxicity and DNA-protein crosslink formation in rat nasal tissues exposed to vinyl acetate are carboxylesterase-mediated. Toxicol. Appl. Pharmacol. 123, 283-292.
-
(1993)
Toxicol. Appl. Pharmacol.
, vol.123
, pp. 283-292
-
-
Kuykendall, J.R.1
Taylor, M.L.2
Bogdanffy, M.S.3
-
38
-
-
0028997789
-
DNA-protein crosslink formation in rat nasal epithelial cells by hexamethylphosphoramide and its correlation with formaldehyde production
-
KUYKENDALL, J.R., TRELA, B.A., and BOGDANFFY, M.S. (1995). DNA-protein crosslink formation in rat nasal epithelial cells by hexamethylphosphoramide and its correlation with formaldehyde production. Mut. Res. 343, 209-218.
-
(1995)
Mut. Res.
, vol.343
, pp. 209-218
-
-
Kuykendall, J.R.1
Trela, B.A.2
Bogdanffy, M.S.3
-
39
-
-
0003122802
-
Preparation and characterisation of microsomal fractions for studies on xenobiotic metabolism
-
K. Snell and B. Mullock (eds.) IRL Press
-
LAKE, B.G. (1987). Preparation and characterisation of microsomal fractions for studies on xenobiotic metabolism, in: Biochemical toxicology. A practical approach. K. Snell and B. Mullock (eds.) IRL Press, pp. 183-215.
-
(1987)
Biochemical Toxicology. A Practical Approach
, pp. 183-215
-
-
Lake, B.G.1
-
40
-
-
0019978319
-
Effect of hepatocyte culture conditions of cytochrome P450-linked drug metabolizing enzymes
-
LAKE, B.G., and PAINE, A.J. (1982). Effect of hepatocyte culture conditions of cytochrome P450-linked drug metabolizing enzymes. Biochem. Pharmacol. 31, 2141-2144.
-
(1982)
Biochem. Pharmacol.
, vol.31
, pp. 2141-2144
-
-
Lake, B.G.1
Paine, A.J.2
-
41
-
-
0025195187
-
Identification and biochemical analysis of novel olfactory-specific cytochrome P-450IIA and UDP-glucuronosyl transferase
-
LAZARD, D., TAL, N., RUBINSTEIN, M., KHEN, M., LANCET, D., and ZUPKO, K. (1990). Identification and biochemical analysis of novel olfactory-specific cytochrome P-450IIA and UDP-glucuronosyl transferase. Biochemistry 29, 7433-7440.
-
(1990)
Biochemistry
, vol.29
, pp. 7433-7440
-
-
Lazard, D.1
Tal, N.2
Rubinstein, M.3
Khen, M.4
Lancet, D.5
Zupko, K.6
-
42
-
-
0029998041
-
Glutathione and glutathione-related enzyme activities of male and female rat hepatocytes under various culture conditions
-
LII, C.K., WANG, S.T., CHEN, H.W., and SHEEN, L.Y. (1996). Glutathione and glutathione-related enzyme activities of male and female rat hepatocytes under various culture conditions. Arch. Toxicol. 70, 822-829.
-
(1996)
Arch. Toxicol.
, vol.70
, pp. 822-829
-
-
Lii, C.K.1
Wang, S.T.2
Chen, H.W.3
Sheen, L.Y.4
-
43
-
-
0025719088
-
Primary culture of rat hepatocytes in the presence of dimethyl sulfoxide - A system to investigate the regulation of cytochrome P450 1A
-
LINDSAY, C.K., CHENERY, R.J., and HAWKSWORTH, G.M. (1991). Primary culture of rat hepatocytes in the presence of dimethyl sulfoxide - a system to investigate the regulation of cytochrome P450 1A. Biochem. Pharmacol. 42, S17-S25.
-
(1991)
Biochem. Pharmacol.
, vol.42
-
-
Lindsay, C.K.1
Chenery, R.J.2
Hawksworth, G.M.3
-
44
-
-
71849104860
-
Protein measurement with the Folin phenol reagent
-
LOWRY, O.H., ROSEBROUGH, N.J., FARR, A.L., and RANDALL, R.J. (1951). Protein measurement with the Folin phenol reagent. J. Biol. Chem. 193, 265-275.
-
(1951)
J. Biol. Chem.
, vol.193
, pp. 265-275
-
-
Lowry, O.H.1
Rosebrough, N.J.2
Farr, A.L.3
Randall, R.J.4
-
45
-
-
0026769974
-
α-Naphthyl butyrate carboxylesterase activity in human and rat nasal tissue
-
MATTES, P.M., and MATTES, W.B. (1992). α-Naphthyl butyrate carboxylesterase activity in human and rat nasal tissue. Toxicol. Appl. Pharmacol. 114, 71-76.
-
(1992)
Toxicol. Appl. Pharmacol.
, vol.114
, pp. 71-76
-
-
Mattes, P.M.1
Mattes, W.B.2
-
46
-
-
0024844385
-
Human nasal epithelium: Characterization and effects of in vitro exposure to sulfur dioxide
-
MCMANUS, M.S., ALTMAN, L.C., KOENIG, J.Q., et al. (1989). Human nasal epithelium: Characterization and effects of in vitro exposure to sulfur dioxide. Exp. Lung Res. 15, 849-865.
-
(1989)
Exp. Lung Res.
, vol.15
, pp. 849-865
-
-
Mcmanus, M.S.1
Altman, L.C.2
Koenig, J.Q.3
-
47
-
-
0025737166
-
Differential stability of drug-metabolizing enzyme activities in primary rat hepatocytes cultured in the absence and presence of dexamethasone
-
MCMILLAN, J.M., . SHADDOCK, J.G., CASCIANO, D.A., ARLOTTO, M.P., and LEAKEY, J.E.A. (1991). Differential stability of drug-metabolizing enzyme activities in primary rat hepatocytes cultured in the absence and presence of dexamethasone. Mut. Res. 249, 81-92.
-
(1991)
Mut. Res.
, vol.249
, pp. 81-92
-
-
Mcmillan, J.M.1
Shaddock, J.G.2
Casciano, D.A.3
Arlotto, M.P.4
Leakey, J.E.A.5
-
48
-
-
0025079673
-
Nonneoplastic nasal lesions in rats and mice
-
MONTICELLO, T.M., MORGAN, K.T., and URAIH, L. (1990). Nonneoplastic nasal lesions in rats and mice. Environ. Health Perspect. 85, 249-274.
-
(1990)
Environ. Health Perspect.
, vol.85
, pp. 249-274
-
-
Monticello, T.M.1
Morgan, K.T.2
Uraih, L.3
-
49
-
-
0028662025
-
P450 in the rat and man: Methods of investigation, substrate specificities and relevance to cancer
-
NEDELCHEVA, V., and GUT, I. (1994). P450 in the rat and man: Methods of investigation, substrate specificities and relevance to cancer. Xenobiotica 24, 1151-1175.
-
(1994)
Xenobiotica
, vol.24
, pp. 1151-1175
-
-
Nedelcheva, V.1
Gut, I.2
-
50
-
-
0024602373
-
Olfactory-specific cytochrome P450: CDNA cloning of a novel neuroepithelial enzyme possibly involved in chemoreception
-
NEF, P., HELDMAN, J., LAZARD, D., et al. (1989). Olfactory-specific cytochrome P450: cDNA cloning of a novel neuroepithelial enzyme possibly involved in chemoreception. J. Biol. Chem. 264, 6780-6785.
-
(1989)
J. Biol. Chem.
, vol.264
, pp. 6780-6785
-
-
Nef, P.1
Heldman, J.2
Lazard, D.3
-
51
-
-
0025859883
-
Rat adult hepatocytes in primary pure and mixed monolayer culture. Comparison of the maintenance of mixed function oxidase and conjugation pathways of drug metabolism
-
NIEMANN, C., GAUTHIER, J.-C., RICHERT, L., IVANOV, M.-A., MELCION, C., and CORDIER, A. (1991). Rat adult hepatocytes in primary pure and mixed monolayer culture. Comparison of the maintenance of mixed function oxidase and conjugation pathways of drug metabolism. Biochem. Pharmacol. 42, 373-379.
-
(1991)
Biochem. Pharmacol.
, vol.42
, pp. 373-379
-
-
Niemann, C.1
Gauthier, J.-C.2
Richert, L.3
Ivanov, M.-A.4
Melcion, C.5
Cordier, A.6
-
52
-
-
0018392357
-
Apparent maintenance of cytochrome P-450 by nicotinamide in primary cultures of rat hepatocytes
-
PAINE, A.J., WILLIAMS, L.J., and LEGG, R.F. (1979). Apparent maintenance of cytochrome P-450 by nicotinamide in primary cultures of rat hepatocytes. Life. Sci. 24, 2185-2192.
-
(1979)
Life. Sci.
, vol.24
, pp. 2185-2192
-
-
Paine, A.J.1
Williams, L.J.2
Legg, R.F.3
-
53
-
-
0018976295
-
Evidence that ligand formation is a mechanism underlying the maintenance of cytochrome P-450 in rat liver cell culture
-
PAINE, A.J., VILLA, P., and HOCKIN, L.J. (1980). Evidence that ligand formation is a mechanism underlying the maintenance of cytochrome P-450 in rat liver cell culture. Biochem. J. 188, 937-939.
-
(1980)
Biochem. J.
, vol.188
, pp. 937-939
-
-
Paine, A.J.1
Villa, P.2
Hockin, L.J.3
-
54
-
-
0027184486
-
Isolation and heterologous expression of two rabbit microsomal proteins, CYP2A10 and CYP2A11, that are related to nasal cytochrome P450 from a
-
PENG, H.-M., DING, X., and COON, M.J. (1993). Isolation and heterologous expression of two rabbit microsomal proteins, CYP2A10 and CYP2A11, that are related to nasal cytochrome P450 from a. J. Biol. Chem. 168, 17253-17260.
-
(1993)
J. Biol. Chem.
, vol.168
, pp. 17253-17260
-
-
Peng, H.-M.1
Ding, X.2
Coon, M.J.3
-
55
-
-
0028048122
-
Detection of genotoxic effects in human gastric and nasal mucosa cells isolated from biopsy samples
-
POOL-ZOBEL, B.L., LOTZMANN, N., KNOLL, M., et al. (1994). Detection of genotoxic effects in human gastric and nasal mucosa cells isolated from biopsy samples. Environ. Mol. Mutagen. 24, 23-45.
-
(1994)
Environ. Mol. Mutagen.
, vol.24
, pp. 23-45
-
-
Pool-Zobel, B.L.1
Lotzmann, N.2
Knoll, M.3
-
56
-
-
0027502038
-
Drug metabolism in the nasal cavity: Relevance to toxicology
-
REED, C.J. (1993). Drug metabolism in the nasal cavity: relevance to toxicology. Drug Met. Rev. 25, 173-205.
-
(1993)
Drug Met. Rev.
, vol.25
, pp. 173-205
-
-
Reed, C.J.1
-
57
-
-
0023028880
-
NADPH: Cytochrome P450 reductase in olfactory epithelium. Relevance to cytochrome P450-dependent reactions
-
REED, C.J., DE MATTEIS, F., and LOCK, E.A. (1986). NADPH: Cytochrome P450 reductase in olfactory epithelium. Relevance to cytochrome P450-dependent reactions. Biochem. J. 240, 589-592.
-
(1986)
Biochem. J.
, vol.240
, pp. 589-592
-
-
Reed, C.J.1
De Matteis, F.2
Lock, E.A.3
-
58
-
-
0004815970
-
-
CRC Press, Boca Raton
-
REZNIK, G., and STINSON, S.F. (1983). Nasal tumours in animals and man, Vols. I-III, CRC Press, Boca Raton.
-
(1983)
Nasal Tumours in Animals and Man
, vol.1-3
-
-
Reznik, G.1
Stinson, S.F.2
-
59
-
-
0027364049
-
Rat hepatocyte cultures and co-cultures in biotransformation studies of xenobiotics
-
ROGIERS, V., and VERCRUYSSE, A. (1993). Rat hepatocyte cultures and co-cultures in biotransformation studies of xenobiotics. Toxicology 82, 193-208.
-
(1993)
Toxicology
, vol.82
, pp. 193-208
-
-
Rogiers, V.1
Vercruysse, A.2
-
60
-
-
0025184995
-
Effects of dimethylsulphoxide on phase I and II biotransformation in cultured rat hepatocytes
-
ROGIERS, V., VANDENBERGHE, Y., CALLAERTS, A., SONCK, W., and VERCRUYSSE, A. (1990a). Effects of dimethylsulphoxide on phase I and II biotransformation in cultured rat hepatocytes. Toxicol. In Vitro 4, 439-442.
-
(1990)
Toxicol. In Vitro
, vol.4
, pp. 439-442
-
-
Rogiers, V.1
Vandenberghe, Y.2
Callaerts, A.3
Sonck, W.4
Vercruysse, A.5
-
61
-
-
0025077628
-
Phase I and phase II xenobiotic biotransformation in cultures and co-cultures of adult rat hepatocytes
-
ROGIERS, V., VANDENBERGHE, Y., CALLAERTS, A., et al. (1990b). Phase I and phase II xenobiotic biotransformation in cultures and co-cultures of adult rat hepatocytes. Biochem. Pharmacol. 40, 1701-1706.
-
(1990)
Biochem. Pharmacol.
, vol.40
, pp. 1701-1706
-
-
Rogiers, V.1
Vandenberghe, Y.2
Callaerts, A.3
-
62
-
-
0027285199
-
Crude liver membrane fractions and extracellular matrix components as substrata regulate differentially the preservation and inducibility of cytochrome P-450 isoenzymes in cultured rat hepatocytes
-
SAAD, B., SCHOLL, F.A., THOMAS, H., et al. (1993). Crude liver membrane fractions and extracellular matrix components as substrata regulate differentially the preservation and inducibility of cytochrome P-450 isoenzymes in cultured rat hepatocytes. Eur. J. Biochem. 213, 805-814.
-
(1993)
Eur. J. Biochem.
, vol.213
, pp. 805-814
-
-
Saad, B.1
Scholl, F.A.2
Thomas, H.3
-
63
-
-
0018519489
-
Drug metobolism and effects of carcinogens in cultured hepatic cells
-
SIRICA, A.E., and PITOT, H.C. (1979). Drug metobolism and effects of carcinogens in cultured hepatic cells. Pharmacol. Rev. 31, 205-228.
-
(1979)
Pharmacol. Rev.
, vol.31
, pp. 205-228
-
-
Sirica, A.E.1
Pitot, H.C.2
-
64
-
-
0028362520
-
Problems in using isolated and cultured hepatocytes for xenobiotic metabolism/metabolism-based toxicity testing - Solutions?
-
SKETT, P. (1994). Problems in using isolated and cultured hepatocytes for xenobiotic metabolism/metabolism-based toxicity testing - solutions? Toxicol. In Vitro 8, 491-504.
-
(1994)
Toxicol. In Vitro
, vol.8
, pp. 491-504
-
-
Skett, P.1
-
65
-
-
0014466646
-
The effects of carbon tetrachloride on rat liver microsomes during the first hour of poisoning in vivo, and the modifying actions of promethazine
-
SLATER, T.F., and SAWYER, B.C. (1969). The effects of carbon tetrachloride on rat liver microsomes during the first hour of poisoning in vivo, and the modifying actions of promethazine. Biochem. J. 111, 317-324.
-
(1969)
Biochem. J.
, vol.111
, pp. 317-324
-
-
Slater, T.F.1
Sawyer, B.C.2
-
66
-
-
0022000618
-
Changes in the concentration of seven forms of cytochrome P-450 in primary cultures of adult rat hepatocytes
-
STEWARD, A.R., DANNAN, G.A., GUZELIAN, P.S., and GUENGERICH, F.P. (1985). Changes in the concentration of seven forms of cytochrome P-450 in primary cultures of adult rat hepatocytes. Mol. Pharmacol. 27, 125-132.
-
(1985)
Mol. Pharmacol.
, vol.27
, pp. 125-132
-
-
Steward, A.R.1
Dannan, G.A.2
Guzelian, P.S.3
Guengerich, F.P.4
-
67
-
-
0018661952
-
Factors regulating drug metabolism in intact hepatocytes
-
THURMAN, R.G., and KAUFMAN, F.C. (1979). Factors regulating drug metabolism in intact hepatocytes. Pharmacol. Rev. 31, 229-252.
-
(1979)
Pharmacol. Rev.
, vol.31
, pp. 229-252
-
-
Thurman, R.G.1
Kaufman, F.C.2
-
68
-
-
0028953238
-
The gap junction intercellular communication is no prerequisite for the stabilization of xenobiotic metabolizing enzyme activities in primary rat live parenchymal cells in vitro
-
TRAISER, M., DIENER, B., UTESCH, D., and OESCH, F. (1995). The gap junction intercellular communication is no prerequisite for the stabilization of xenobiotic metabolizing enzyme activities in primary rat live parenchymal cells in vitro. In Vitro Cell. Dev. Biol. 31, 266-273.
-
(1995)
In Vitro Cell. Dev. Biol.
, vol.31
, pp. 266-273
-
-
Traiser, M.1
Diener, B.2
Utesch, D.3
Oesch, F.4
-
69
-
-
0026081154
-
Carboxylesterase-dependent cytotoxicity of dibasic esters (DBE) in rat nasal explants
-
TRELA, B.A., and BOGDANFFY, M.S. (1991a). Carboxylesterase-dependent cytotoxicity of dibasic esters (DBE) in rat nasal explants. Toxicol. Appl. Pharmacol. 107, 285-301.
-
(1991)
Toxicol. Appl. Pharmacol.
, vol.107
, pp. 285-301
-
-
Trela, B.A.1
Bogdanffy, M.S.2
-
70
-
-
0026091254
-
Cytotoxicity of dibasic esters (DBE) metabolites in rat nasal explants
-
TRELA, B.A., and BOGDANFFY, M.S. (1991b). Cytotoxicity of dibasic esters (DBE) metabolites in rat nasal explants. Toxicol. Appl. Pharmacol. 110, 259-267.
-
(1991)
Toxicol. Appl. Pharmacol.
, vol.110
, pp. 259-267
-
-
Trela, B.A.1
Bogdanffy, M.S.2
-
71
-
-
0023614182
-
The effect of dexamethasone, insulin and tri-iodothyronine on microsomal NADPH-cytochrome c (P450) reductase in primary cultures of isolated hepatocytes
-
VAN DER HOEVEN, T., AND GALIVAN, J. (1987). The effect of dexamethasone, insulin and tri-iodothyronine on microsomal NADPH-cytochrome c (P450) reductase in primary cultures of isolated hepatocytes. Biochim. Biophys. Acta 931, 59-67.
-
(1987)
Biochim. Biophys. Acta
, vol.931
, pp. 59-67
-
-
Van Der Hoeven, T.1
Galivan, J.2
-
72
-
-
0023922645
-
Glutathione transferase isoenzymes in cultured rat hepatocytes
-
VANDENBERGHE, Y., GLAISE, D., MEYER, D.J., GUILLOUZO, A., and KETTERER, B. (1988a). Glutathione transferase isoenzymes in cultured rat hepatocytes. Biochem. Pharmacol. 37, 2482-2485.
-
(1988)
Biochem. Pharmacol.
, vol.37
, pp. 2482-2485
-
-
Vandenberghe, Y.1
Glaise, D.2
Meyer, D.J.3
Guillouzo, A.4
Ketterer, B.5
-
73
-
-
0023917839
-
Influence of medium composition and culture conditions on glutathione S-transferase activity in adult rat hepatocytes during culture
-
VANDENBERGHE, Y., RATANASAVANH, D., GLAISE, D., and GUILLOUZO, A. (1988b). Influence of medium composition and culture conditions on glutathione S-transferase activity in adult rat hepatocytes during culture. In Vitro Cell. Dev. Biol. 24, 281-288.
-
(1988)
In Vitro Cell. Dev. Biol.
, vol.24
, pp. 281-288
-
-
Vandenberghe, Y.1
Ratanasavanh, D.2
Glaise, D.3
Guillouzo, A.4
-
74
-
-
0023858606
-
The content and activity of cytochrome P-450 in long-term cultures of hepatocytes from male and female rats
-
VIND, C., DICH, J., and GRUNNET, N. (1988). The content and activity of cytochrome P-450 in long-term cultures of hepatocytes from male and female rats. Biochem. Pharmacol. 37, 1371-1375.
-
(1988)
Biochem. Pharmacol.
, vol.37
, pp. 1371-1375
-
-
Vind, C.1
Dich, J.2
Grunnet, N.3
-
75
-
-
0025646324
-
The isoenzyme pattern of cytochorme P450 in rat hepatocytes in primary culture, comparing different enzyme activities in microsomal incubations and in intact monolayers
-
WORTELBOER, H.M., DE KRUIF, C.A., VAN IERSEL, A.A.J., FALKE, H.E., NOORDHOEK, J., and BLAAUBOER, B.J. (1990). The isoenzyme pattern of cytochorme P450 in rat hepatocytes in primary culture, comparing different enzyme activities in microsomal incubations and in intact monolayers. Biochem. Pharmacol. 40, 2525-2534.
-
(1990)
Biochem. Pharmacol.
, vol.40
, pp. 2525-2534
-
-
Wortelboer, H.M.1
De Kruif, C.A.2
Van Iersel, A.A.J.3
Falke, H.E.4
Noordhoek, J.5
Blaauboer, B.J.6
-
76
-
-
0029933045
-
Characterization of a primary hepatocyte culture system for toxicological studies
-
ZURLO, J., and ARTERBURN, L.M. (1996). Characterization of a primary hepatocyte culture system for toxicological studies. In Vitro Cell Dev. Biol. 32, 211-220.
-
(1996)
In Vitro Cell Dev. Biol.
, vol.32
, pp. 211-220
-
-
Zurlo, J.1
Arterburn, L.M.2
|