Convergent synthesis of S-8921, a new potent hypocholesterolemic arylnaphthalene lignan analog

Tetrahedron Letters

Volumn 40, Issue 6, 1999, Pages 1165-1168

  Mori, S ^a   Takechi, S ^a   Shimizu, S ^a   Kida, S ^a   Iwakura, H ^a   Hajima, M ^a  

^a SHIONOGI AND CO LTD   (Japan)

Author keywords

Condensations; Coupling reactions; Fridel Crafts reactions; Lignans; Michael reactions; Regiocontrol

Indexed keywords

1 (3,4 DIMETHOXYPHENYL) 3 (3 ETHYLVALERYL) 4 HYDROXY 6,7,8 TRIMETHOXY 2 NAPHTHOIC ACID METHYL ESTER; HYPOCHOLESTEROLEMIC AGENT;

ARTICLE; DRUG POTENCY; DRUG SYNTHESIS; HYPERCHOLESTEROLEMIA; JAPAN; POLYMERIZATION;

EID: 0033524755     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0040-4039(98)02554-4     Document Type: Article

References (6)

1. T Ichihashi M Izawa K Miyata T Mizui K Hirano Y Takagishi J. Pharmacol. Exp. Ther. 284 1 1998 43 50
2. S Hara J Higaki K Higashino M Iwai N Takasu K Miyata K Tonda K Nagata Y Go T Mizui Life Sci. 60 24 1997 365 370
3. S Mori S Takechi S Kida T Mizui T Ichihashi Lignan analog, production thereof, and hypolipidemic drug April 29, 1993 PCT WO 93/08155
4. HP Plaumann JG Smith R Rodrigo J. Chem. Soc. Chem. Commun. 1980 354 355
5. M Tamura JK Kochi J. Organomet. Chem. 42 1972 205 228
6. Coupling reactions between simple phthalides and α,β-unsaturated esters, see JP Bloom PG Sammes J. Chem. Soc. Chem. Commun. 1978 162 164