Effects of isopropyl unoprostone on rabbit ciliary artery

Japanese Journal of Ophthalmology

Volumn 44, Issue 3, 2000, Pages 214-220

  Hayashi, Eri ^a   Yoshitomi, Takeshi ^b   Ishikawa, Hitoshi ^a   Hayashi, Ryoko ^a   Shimizu, Kimiya ^a  

^a KITASATO UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b WAKAYAMA MEDICAL UNIVERSITY   (Japan)

Author keywords

Ciliary artery; Isopropyl unoprostone; Ocular blood flow; Relaxation; Vascular smooth muscle

Indexed keywords

CALCITONIN GENE RELATED PEPTIDE; DILTIAZEM; N(G) NITROARGININE METHYL ESTER; UNOPROSTONE ISOPROPYL ESTER;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CILIARY ARTERY; CONTROLLED STUDY; DRUG MECHANISM; EYE BLOOD FLOW; GLAUCOMA; INTRAOCULAR PRESSURE; MALE; NONHUMAN; PRIORITY JOURNAL; RABBIT; VASCULAR SMOOTH MUSCLE; VASODILATATION;

ANIMALS; CALCITONIN GENE-RELATED PEPTIDE; CILIARY ARTERIES; DILTIAZEM; DINOPROST; ELECTROMYOGRAPHY; ENDOTHELIUM, VASCULAR; ENZYME INHIBITORS; ISOMETRIC CONTRACTION; MALE; MUSCLE, SMOOTH, VASCULAR; NG-NITROARGININE METHYL ESTER; RABBITS; VASOCONSTRICTION; VASODILATOR AGENTS;

EID: 0034611994     PISSN: 00215155     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0021-5155(99)00215-4     Document Type: Article

References (26)

1. Flammer J. The vascular concept of glaucoma. Surv Ophthalmol. 38:1994;S3-S6.
2. Yamazaki Y., Drance S. The relationship between progression of visual field defects and retrobulbar circulation in patients with glaucoma. Am J Ophthalmol. 124:1997;287-295.
3. Harris A., Sergott R.C., Spaeth G.L., Katz J.L., Shoemaker J.A., Martin B.J. Color Doppler analysis of ocular vessel blood velocity in normal-tension glaucoma. Am J Ophthalmol. 118:1994;642-649.
4. ®; isopropyl unoprostone). Surv Ophthalmol. 41(Suppl 2):1997;S99-103.
5. Sakurai M., Araie M., Oshika T.et al. Effects of topical application of UF-021, a novel prostaglandin derivative, on aqueous humor dynamics in normal human eyes. Jpn J Ophthalmol. 35:1991;156-165.
6. Sakurai M., Araie M., Oshika T., Mori M., Shoji N., Masuda K. Effects of topical application of UF-021, a novel prostaglandin-related compound, on aqueous humor dynamics in rabbit. Jpn J Ophthalmol. 37:1993;252-258.
7. Taniguchi T., Haque M.S., Sugiyama K., Hori N., Kitazawa Y. Ocular hypotensive mechanism of topical isopropyl unoprostone, a novel prostaglandin metabolite-related drug, in rabbits. J Ocul Pharmacol Ther. 12:1996;489-498.
8. ® on ocular circulation. Atarashii Ganka (J Eye). 13:1996;1422-1424.
9. Sugiyama T., Azuma I. Effect of UF-021 on optic nerve head circulation in rabbits. Jpn J Ophthalmol. 39:1995;124-129.
10. Ogo T. Effect of isopropyl unoprostone on choroidal circulation. Nihon Ganka Kiyo (Folia Ophthalmol Jpn). 47:1996;268-272.
11. Kojima S., Sugiyama T., Azuma I., Konishi N., Fujii H. Effect of topically applied isopropyl unoprostone on microcirculation in the human ocular fundus evaluated with a laser speckle microcirculation analyser. Nippon Ganka Gakkai Zasshi (J Jpn Ophthalmol Soc). 101:1997;605-610.
12. Nyborg N., Korsgaard N., Nielsen P. Active wall tension-length curve and morphology of isolated bovine retinal small arteries. important feature for pharmacodynamic studies Exp Eye Res. 51:1990;217-224.
13. Mulvany M., Halpern W. Contractile properties of small arterial resistance vessels in spontaneously hypertensive and normotensive rats. Circ Res. 41:1977;19-26.
14. Furchgott R.F., Zawadzki J.V. The obligatory role of endothelial cells in the relaxation of arterial muscle by acetylcholine. Nature. 288:1980;373-376.
15. Ignarro L.J., Byrns R.E., Buga G.M., Wood K.S. Endothelium-derived relaxing factor from pulmonary artery and vein possesses pharmacologic and chemical properties identical to those of nitric oxide radical. Circ Res. 60:1987;82-92.
16. Palmer R.M.J., Ferrige A.G., Moncada S. Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor. Nature. 327:1987;524-526.
17. Rees D.D., Palmer R.M.J., Hodson H.F., Moncada S. A specific inhibitor of nitric oxide formation from L-arginine attenuates endothelium-dependent relaxation. Br J Pharmacol. 96:1989;428.
18. Chen G., Suzuki H., Weston A.H. Acetylcholine releases endothelium-derived hyperpolarizing factor and EDRF from rat blood vessels. Br J Pharmacol. 95:1988;1165-1174.
19. Humphries R.G., Tomlinson W., O'Connor S.E., Leff P. Inhibition of collagen- and ADP-induced platelet aggregation by substance P in vivo. involvement of endothelium-derived relaxing factor J Cardiovasc Pharmacol. 16:1990;292-297.
20. Rubanyi G.M., Vanhoufte P.M. Calcium and activation of the release of endothelium-derived relaxing factor. Ann NY Acad Sci. 522:1988;226-233.
21. Stewart A.G., Piper P.J. Vasodilator actions of acetylcholine, A23187 and bradykinin in guinea-pig isolated perfused heart are independent of prostacyclin. Br J Pharmacol. 95:1988;379-384.
22. Wiencke A., Nilsson H., Nielsen P., Nyborg N. Nonadrenergic noncholinergic vasodilation in bovine ciliary artery involves CGRP and neurogenic nitric oxide. Invest Ophthalmol Vis Sci. 35:1994;3268-3277.
23. Dennis T., Fournier A., Cadieux A., Pomerleau F., Jolicoeur F.B., St. Pierre S., Quirion R. hCGRP8-37, a calcitonin gene-related peptide antagonist revealing calcitonin gene-related peptide receptor heterogeneity in brain and periphery. J Pharmacol Exp Ther. 254:1990;123-128.
24. Hayashi-Morimoto R., Yoshitomi T., Ishikawa H., Hayashi E., Sato Y. Effects of β antagonists on mechanical properties in rabbit ciliary artery. Graefe's Arch Clin Exp Ophthalmol. 237:1999;661-667.
25. 2+ release in flow-induced contraction of venous smooth muscle. Hypertension. 26:1995;1051-1055.
26. Watanabe C., Matsumoto S., Kin K., Tsuchisaka H., Ueno R. Ocular penetration of UF-021, a new prostaglandin related compound, in the rabbit eye. Nippon Ganka Gakkai Zasshi (Acta Soc Ophthalmol). 96:1992;335-339.