Massive idiosyncratic exon skipping corrects the nonsense mutation in dystrophic mouse muscle and produces functional revertant fibers by clonal expansion

Journal of Cell Biology

Volumn 148, Issue 5, 2000, Pages 985-995

  Lu, Q L ^a   Morris, G E ^b   Wilton, S D ^c   Ly, T ^c   Artem'yeva, O V ^d   Strong, P ^e   Partridge, T A ^a  

^a HAMMERSMITH HOSPITAL   (United Kingdom)

^b GLYNDWR UNIVERSITY   (United Kingdom)

^c Department of Forensic Pathology State Health Laboratories QEII Medical Center   (Australia)

^d UNIVERSITY OF LONDON   (United Kingdom)

^e SHEFFIELD HALLAM UNIVERSITY   (United Kingdom)

Author keywords

Dystrophin; Exon mapping; Nonsense mutation; Reversion; Splicing

Indexed keywords

DYSTROPHIN; GLYCOPROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL MEMBRANE; CONTROLLED STUDY; DUCHENNE MUSCULAR DYSTROPHY; EXON; EXPRESSION VECTOR; GENE DELETION; GENE MAPPING; GENE THERAPY; MALE; MOLECULAR CLONING; MOUSE; MUSCLE GROWTH; NONHUMAN; NONSENSE MUTATION; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN ASSEMBLY; PROTEIN SYNTHESIS INHIBITION; REVERTANT; RNA SPLICING;

AGING; ALTERNATIVE SPLICING; ANIMALS; ANTIBODIES; CELL NUCLEUS; CODON, NONSENSE; DYSTROPHIN; EPITOPES; EXONS; IMMUNOHISTOCHEMISTRY; MALE; MEMBRANE PROTEINS; MICE; MICE, INBRED C57BL; MICE, INBRED MDX; MUSCLE FIBERS; MUSCLE, SKELETAL; MUSCULAR DYSTROPHY, ANIMAL; PROTEIN STRUCTURE, TERTIARY; RNA, MESSENGER;

ANIMALIA; RODENTIA;

EID: 0034611016     PISSN: 00219525     EISSN: None     Source Type: Journal    
DOI: 10.1083/jcb.148.5.985     Document Type: Article

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