Synthesis and opioid receptor affinity of a series of 2,4-diaryl-substituted 3,7-diazabicylononanones

Journal of Medicinal Chemistry

Volumn 43, Issue 20, 2000, Pages 3746-3751

  Siener, T ^a   Cambareri, A ^a   Kuhl, U ^a   Englberger, W ^b   Haurand, M ^b   Kogel, B ^b   Holzgrabe, U ^a  

^a UNIVERSITY OF WÜRZBURG   (Germany)

^b GRÜNENTHAL GMBH   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

1,2,3,4,4A,5,12,12AALPHA OCTAHYDRO 4AALPHA (3 HYDROXYPHENYL) 2 METHYLQUINOLINO[2,3 G]ISOQUINOLINE; 3,7 DIAZABICYCLO[3.3.1]NONAN 9 ONE DERIVATIVE; 3,7 DIAZABICYCLONONANONE DERIVATIVE; 3,7 DIMETHYL 3,7 DIAZA 9 OXOBICYCLO[3.3.1]NONANE 1,5 DICARBOXYLATE; ASIMADOLINE; BICYCLO COMPOUND; DELTA OPIATE RECEPTOR; KAPPA OPIATE RECEPTOR; MU OPIATE RECEPTOR; N METHYL N [7 (1 PYRROLIDINYL) 1 OXASPIRO[4.5]DEC 8 YL]BENZENEACETAMIDE; NONANOIC ACID; OPIATE RECEPTOR; UNCLASSIFIED DRUG;

ANALGESIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG STRUCTURE; DRUG SYNTHESIS; LIGAND BINDING; MALE; MOUSE; NONHUMAN; PAIN; RAT; RECEPTOR AFFINITY; RHEUMATOID ARTHRITIS; SOLUBILITY; STRUCTURE ACTIVITY RELATION;

ANALGESICS; ANIMALS; BICYCLO COMPOUNDS, HETEROCYCLIC; BRAIN; HUMANS; MALE; MICE; RADIOLIGAND ASSAY; RATS; RATS, WISTAR; RECEPTORS, OPIOID, DELTA; RECEPTORS, OPIOID, KAPPA; RECEPTORS, OPIOID, MU; SOLUBILITY; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0034609861     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm0009484     Document Type: Article

References (25)

1. Emerging molecular approaches to pain therapy
2. Spinal systems and pain processing: Development of novel analgesic drugs with mechanistically defined models
3. Ions in the fire: Recent ion-channel and approaches to pain therapy
4. Opioid-agonisten und -antagonisten, opioid-rezeptoren
5. Novel development with selective, nonpeptidic kappa-opioid receptor agonists
6. Novel molecular approaches to analgesia
7. Peripheral component in the enhanced antinociceptive effect of systemic U-69,593, a κ-opioid receptor agonist in mononeuropathic rats
8. κ Opioid receptors in human microglia downregulate human immunodefiency virus 1 expression
9. Non-peptide δ opioid agonists and antagonists
10. Structurally novel group of ligands selective for kappa-opioid receptors
11. Search for the pharmacophore in kappa-agonistic diazabicyclo[3.3.1]nonan-9-one-1,5-diesters and arylacetamides
12. HZ2 a selective κ-opioid agonist
13. Interdependence between physical parameters and selection of substituent groups for correlation studies
14. Uber die condensation von acetondicarbonsaureestern mit benzaldehyd unter anwendung von ammoniak
15. Uber derivate eines aus zwei piperidinringen kondensierten bicyclischen systems
16. Conformational and configurational behaviour of κ-agonistic 3,7-diazabicyclo[3.3.1]nonan-9-ones - Synthesis, nuclear magnetic resonance studies and semiempirical PM3 calculations
17. Dissociation constants of some carboxylic acids in mixed aqueous solvents
18. Octanol-, chloroform-, and propylene glycol dipelargonat-water partitioning of morphine-6-glucuronide and other related opiates
19. Synthese und stereochemie potentiell stark analgetischer 2,4-m-diarylsubstituierter 3,7-Diazabicyclo[3.3.1]nonan-9-on-1,5-diester
20. Synthesis, X-ray analysis and spectroscopic characterization of the hemiaminal cyclisation product from 2-dipyridine substituted 3,7-diazabicyclo[3.3.1]nonanone 1,5-diester
21. Multiple opiate receptors: Differential binding of μ, κ and δ agonists
22. Protein measurement with the folin phenol reagent
23. 50) of an enzymatic reaction
24. Antagonism of the frequency of phenylcholine-induced writhing in the mouse by weak analgesics and nonanalgesics
25. A method for determining loss of pain sensations