O-glycosyl trichloroacetimidates bearing Fmoc as temporary hydroxy protecting group: A new access to solid-phase oligosaccharide synthesis

Organic Letters

Volumn 2, Issue 20, 2000, Pages 3043-3046

  Roussel, Fabien ^a   Knerr, Laurent ^a,b   Grathwohl, Matthias ^a   Schmidt, Richard R ^a  

^a UNIVERSITY OF KONSTANZ   (Germany)

^b UCB PHARMA   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

OLIGOSACCHARIDE;

ARTICLE; CARBOHYDRATE ANALYSIS; MOLECULAR GENETICS; SYNTHESIS;

CARBOHYDRATE SEQUENCE; MOLECULAR SEQUENCE DATA; OLIGOSACCHARIDES;

EID: 0034609692     PISSN: 15237060     EISSN: None     Source Type: Journal    
DOI: 10.1021/ol006081l     Document Type: Article

References (30)

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23. 1,2 = 3.5 Hz, 1-Hα).
24. 3CN (3 mL) under Ar. Sodium hydride (0.1 equiv, 0.5 mg) was added to the solution, and after 10 min of stirring, a TLC analysis showed a complete consumption of the starting material. The solution was adsorbed on silica, and the solvents were evaporated in vacuo. The residue was purified by flash chromatography (very small amount of silica) to afford imidate 1b in a 97% yield.
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30. 3) δ 3.34 (5b-H), 3.37 (2a-H), 3.42 (5a-H), 3.62 (3b-H), 3.70 (4b-H), 3.71 (2b-H), 3.86 (4a-H), 4.20 (1b-H), 4.60 (1a-H), 5.44-5.45 (1c-H).