Solid phase synthesis of polylactosamine oligosaccharide

Bioorganic and Medicinal Chemistry Letters

Volumn 6, Issue 23, 1996, Pages 2841-2846

  Shimizu, Hiroki ^a   Ito, Yukishige ^a   Kanie, Osamu ^a   Ogawa, Tomoya ^a  

^a INST OF PHYS AND CHEMICAL RESEARCH   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

OLIGOSACCHARIDE;

ARTICLE; CARBOHYDRATE SYNTHESIS; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; REACTION ANALYSIS; TECHNIQUE;

EID: 0030568126     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(96)00535-5     Document Type: Article

References (26)

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19. 2 successively, and dried under vacuum to afford to 1a (1.098 g, 96%, 0.132 mmol/g). Loading of 5b on resin was performed in a nearly identical manner after converted into corresponding acid to afford 1b (99% yield, 0.094 mmol/g). In this instance, the degree of substitution was confirmed to be >90% of the theoretical value based on the mass recovery of the cleavage experiment (NaOMe / MeOH, 45°C).
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23. 17. Corresponding hexasaccharide was also isolated in 15% yield.
24. 2O/pyridine, r.t. overnight) of unreacted acceptor.
25. 4-Higher oligosaccharide portion of this material revealed to consist of ∼93% hexa-and ∼7% tetrasaccharide.
26. 20. O. Kanie, S. C. Crawley, M. M. Palcic, O. Hindsgaul, Carbohydr. Res. 1993, 243, 139.