Mass spectrometry reveals elastase inhibitors from the reactive centre loop of α1-antitrypsin

Bioorganic and Medicinal Chemistry Letters

Volumn 10, Issue 11, 2000, Pages 1219-1221

  Wright, Penny A ^a   Rostom, Adam A ^a   Robinson, Carol V ^a   Schofield, Christopher J ^a  

^a UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA 1 ANTITRYPSIN DERIVATIVE; CHYMOTRYPSIN; ELASTASE INHIBITOR; LEUKOCYTE ELASTASE; UNCLASSIFIED DRUG;

ARTICLE; DRUG SCREENING; HUMAN; HUMAN CELL; LEUKOCYTE; MASS SPECTROMETRY; NONHUMAN; PROTEIN MODIFICATION;

ALPHA 1-ANTITRYPSIN; AMINO ACID SEQUENCE; ANIMALS; ENZYME INHIBITORS; HUMANS; KINETICS; MASS SPECTROMETRY; PANCREATIC ELASTASE; SWINE;

SUIDAE;

EID: 0034608595     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(00)00194-3     Document Type: Article

References (20)

1. Cornish-Bowden A. FEBS Letts. 203:1986;3.
2. Cheng X.H., Chen R.D., Bruce J.E., Schwartz B.L., Anderson G.A., Hofstadler S.A., Gale D.C., Smith R.D., Gao J.M., Sigal G.B., Mammen M., Whtesides G.M. J. Am. Chem. Soc. 117:1995;8859.
3. Pitt A.R. Nat. Prod. Reps. 15:1998;59.
4. Wilmouth R.C., Clifton I.J., Robinson C.V., Roach P.L., Aplin R.T., Westwood N.J., Hajdu J., Schofield C.J. Nature Struct. Biol. 4:1997;456.
5. Carrell, R. W.; Boswell, D. R. In Proteinase Inhibitors; Salvesen, B. A., Ed.; Elsevier Science Publishers BV (Biomedical Division): 1986, pp 403-420.
6. Heimburger, N.; Haupt, H.; Schwick, H. In Proceedings of the First International Research Conference on Proteinase Inhibitors (1970); Walter de Gruyter: New York, 1971.
7. Stone S.R., Whisstock J.C., Bottomley S.P., Hopkins P.C.R. Adv. Exp. Med. Biol. 425:1997;5.
8. ESI MS analyses used a Micromass Platform II mass spectometer. Micromass Mass Lynx software was used for data processing.
9. 13 methods. Data analysis used standard kinetic equations programmed into the program Grafit.
10. Del Mar E.G., Largman C., Brodrick J.W., Fassett M., Geokas M.C. Biochemistry. 19:1980;468.
11. Lineweaver H., Burk D. J. Amer. Chem. Soc. 56:1934;658.
12. Dixon M. Biochem. J. 55:1953;170.
13. Cornish-Bowden A. Biochem. J. 137:1974;143.
14. 15 Such non-productive binding modes may be reinforced under ESI MS conditions.
15. Hughes D.L., Sieker L.C., Bieth J., Dimicoli J.-L. J. Mol. Biol. 162:1982;645.
16. Patson P.A., Gettins P., Beecham J., Schapira M. Biochemistry. 30:1991;8876.
17. Rubin H.M., Wang Z.M., Nickbarg E.B., McLarney S., Naidoo N., Schoenberger O.L., Johnson J.L., Cooperman B.S. J. Biol. Chem. 265:1991;119.
18. Patson P.A., Gettins P.G.W., Schapira M. Annals New York Acad. Sci. 714:1994;13.
19. Niemann M.A., Narkates A.J., Miller E.J. Matrix. 12:1992;233.
20. Niemann M.A., Baggott J.E., Miller E.J. Biochem. Biophys. Acta. 1340:1997;123.