Serpins: A mechanistic class of their own

Advances in Experimental Medicine and Biology

Volumn 425, Issue , 1997, Pages 5-15

  Stone, Stuart R ^a   Whisstock, James C ^a,b   Bottomley, Stephen P ^a,b   Hopkins, Paul C R ^a,c  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^b MONASH UNIVERSITY   (Australia)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA 1 ANTITRYPSIN; LEUKOCYTE ELASTASE; PLASMINOGEN ACTIVATOR INHIBITOR 1; SERINE PROTEINASE; SERINE PROTEINASE INHIBITOR; SUICIDE SUBSTRATE; TISSUE PLASMINOGEN ACTIVATOR;

ARTICLE; CONFORMATIONAL TRANSITION; ENZYME ACTIVE SITE; ENZYME INHIBITOR COMPLEX; ENZYME INHIBITOR INTERACTION; ENZYME MECHANISM; ENZYME STRUCTURE; MICHAELIS CONSTANT; PRIORITY JOURNAL; PROTEINASE INHIBITION;

EID: 0031454466     PISSN: 00652598     EISSN: None     Source Type: Book Series    
DOI: 10.1007/978-1-4615-5391-5_2     Document Type: Article

References (28)

1. Laskowski, M. J. and Kato, I. (1980) Protein inhibitors of proteinases. Annu. Rev. Biochem. 49: 593-626.
2. Bode, W. and Huber, R. (1992) Natural protein proteinase-inhibitors and their interaction with proteinases. Eur. J. Biochem. 204: 433-451.
3. Schechter, I. and Berger, A. (1967) On the size of the active site in proteases. I. Papain. Biochem. Biophys. Res. Commun. 27: 157-162.
4. 1-antiproteinase inhibitor: Crystal structure analysis of two crystal modifications, molecular model and preliminary analysis of function. J. Mol. Biol. 177: 531-556.
5. Mottonen, J., Strand, A., Symersky, J., Sweet, R. M., Danley, D. E., Geoghegan, K. F., Gerard, R. D. and Goldsmith, E. J. (1992) Structural basis of latency in plasminogen activator inhibitor-1. Nature 355: 270-273.
6. Carrell, R. W., Stein, P. E., Fermi, G. and Wardell, M. R. (1994) Biological implications of a 3 ̊ structure of dimeric antithrombin. Structure 2: 257-270.
7. Wei, A., Rubin, H., Cooperman, B. S. and Christianson, D. W. (1994) Crystal structure of an uncleaved serpin reveals the conformation of the inhibitory reactive loop. Nature Struct. Biol. 1: 251-258.
8. 1-antitrypsin. Nature Struct. Biol., in press.
9. Skriver, K., Wikoff, W. R., Patston, P. A., Tausk, F., Schapira, M., Kaplan, A. P. and Bock, S. C. (1991) Substrate properties of C1 inhibitor Ma (alanine 434→glutamic acid). Genetic and structural evidence suggesting that the P12 region contains critical determinants of serine protease inhibitor/substrate status. J. Biol. Chem. 266: 9216-9221.
10. 1-Antiproteinase inhibitor variant T345R. Influence of P14 residue on substrate and inhibitory pathways. Biochemistry 33: 8533-8547.
11. Hopkins, P. C. R., Carrell, R. W. and Stone, S. R. (1993) Effects of mutations in the hinge region of serpins. Biochemistry 32: 7650-7657.
12. 1-antitrypsin to its reaction with elastase. Biochemistry 34: 15872-15879.
13. Stein, P. E. and Carrell, R. W. (1995) What do dysfunctional serpins tell us about molecular mobility and disease? Nature Struct. Biol. 2: 96-113.
14. Fish, W. W. and Björk, I. (1979) Release of two-chain antithrombin from the antithrombin-thrombin complex. Eur. J. Biochem. 101: 31-38.
15. Cooperman, B. S., Stavridi, E., Nickbarg, E., Rescorla, E., Schechter, N. M. and Rubin, H. (1993) Antichymotrypsin interaction with chymotrypsin - partitioning of the complex.J. Biol. Chem. 268: 23616-23625.
16. Patston, P. A., Gettins, P., Beechem J. and Schapira, M. (1991) Mechanism of serpin action - evidence that Cl inhibitor functions as a suicide substrate. Biochemistry 30: 8876-8882.
17. Olson, S. T., Bock, P. E., Kvassman, J., Shore, J. D., Lawrence, D. A., Ginsburg, D. and Björk, I. (1995) Role of the catalytic serine in the interactions of serine proteinases with protein inhibitors of the serpin family. J. Biol. Chem. 270: 30007-30017.
18. Lijnen, H. R., Van Hoef, B. and Collen, D. (1991) On the reversible interaction of plasminogen-activator inhibitor-1 with tissue-type plasminogen activator and with urokinase-type plasminogen-activator. J. Biol. Chem. 266: 4041-4044.
19. Stone, S. R. and Le Bonniec, B. F. (1996) Inhibitory mechanism of serpins. Identification of steps involving the active-site serine of the protease. Submitted for publication.
20. Engh, R. A., Huber, R., Bode, W. and Schulze, A. J. (1995) Divining the serpin inhibition mechanism: A suicide substrate 'springe'? Trends Biotechnol. 13: 503-510.
21. Matheson, N. R., van Halbeek, H. and Travis, J. (1991) Evidence of a tetrahedral intermediate complex during serpin-proteinase interactions. J. Biol. Chem. 266: 13489-13491.
22. Lawrence, D. A., Ginsburg, D., Day, D. E. , Berkenpas, M. B., Verhamme, I. M, Kvassman., J.-O. and Shore , J. D. (1995) Serpin-protease complexes are trapped as stable acyl-enzyme intermediates. J. Biol. Chem. 270: 25309-25312.
23. Wilczynska, M., Fa, M., Ohlsson, P.-I. and Ny, T. (1995) The inhibition mechanism of serpins. Evidence that the mobile reactive center loop is cleaved in the native protease-inhibitor complex. J. Biol. Chem. 270: 29652-29655.
24. Carter, P. and Wells, J. A. (1988) Dissecting the catalytic triad of a serine protease. Nature. 332: 564-568.
25. Corey, D. R. and Craik, C. S. (1992) An investigation into the minimum requirements for peptide hydrolysis by mutation of the catalytic triad of trypsin. J. Am. Chem. Soc. 114: 1784-1790.
26. Wright, H. T. and Scarsdale, J. N. (1995) Structural basis for serpin inhibitor activity. Proteins Struct. Funct. Genet. 22: 210-225.
27. Shore, J. D., Day, D. E., Francis-Chmura, A. M., Verhamme, I., Kvassman, J., Lawrence, D. A. and Ginsburg, D. (1995) A fluorescent probe study of plasminogen activator inhibitor-1. Evidence for reactive center loop insertion and its role in the inhibitory mechanism. J. Biol. Chem. 270: 5395-5398.
28. Whisstock, J. C., Lesk, A. M. and Carrell, R. W. (1996) Modelling of serpin-protease complexes: Antithrombin-thrombin, antitrypsin-thrombin, antitrypsin-trypsin and antitrypsin-elastase. Proteins Struct. Funct. Genet., in press.