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0342801449
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note
-
13C NMR of the crude product indicate that the 4-methylamino-3-nitrobenzyl group is attached to the primary side of the cyclodextrin. Since this is a mixture of varying degrees of silylation on the secondary side of cyclodextrin as indicated by TLC, a complete characterization of this product is not possible. This intermediate, when refluxed with 8 equiv of TBAF in THF overnight, gives the same final product 8 after appropriate workup.
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29
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0342801448
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-
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0343236064
-
-
note
-
Calculated assuming all seven hydroxyl groups are substituted.
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