In vivo role of endothelin-converting enzyme-1 as examined by adenovirus-mediated overexpression in rats

Journal of Cardiovascular Pharmacology

Volumn 31, Issue SUPPL. 1, 1998, Pages

  Telemaque S ^a,b   Emoto, N ^a   DeWit, D ^a   Yanagisawa, M ^a,b  

^a UNIVERSITY OF TEXAS AT DALLAS   (United States)

^b UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

Adenovirus; Blood pressure; ECE inhibitor; Endothelin 1

Indexed keywords

2 (4 BIPHENYLYL) 1 (1H TETRAZOL 5 YL)ETHYLAMINOMETHYLPHOSPHONIC ACID; 2 [[2 [[2 [[(HEXAHYDRO 1H AZEPIN 1 YL)CARBONYL]AMINO] 4 METHYLPENTANOYL]AMINO] 3 (1 METHYL 1H INDOL 3 YL)PROPIONYL]AMINO] 3 (2 PYRIDYL)PROPIONIC ACID; ASPARTIC PROTEINASE; AZEPINE DERIVATIVE; COMPLEMENTARY DNA; ENDOTHELIN; ENDOTHELIN 1; ENDOTHELIN A RECEPTOR; ENDOTHELIN CONVERTING ENZYME; ENDOTHELIN RECEPTOR; ENDOTHELIN-CONVERTING ENZYME 1; INDOLE DERIVATIVE; METALLOPROTEINASE; PHOSPHONIC ACID DERIVATIVE; PROTEIN PRECURSOR; PROTEINASE INHIBITOR; TETRAZOLE DERIVATIVE;

ANIMAL; ARTICLE; BIOSYNTHESIS; BLOOD; BLOOD PRESSURE; CATTLE; DRUG ANTAGONISM; DRUG EFFECT; HUMAN; HYPERTENSION; MALE; METABOLISM; RAT; VIRUS INFECTION; WISTAR RAT;

ADENOVIRIDAE INFECTIONS; ANIMALS; ASPARTIC ENDOPEPTIDASES; AZEPINES; BLOOD PRESSURE; CATTLE; DNA, COMPLEMENTARY; ENDOTHELIN-1; ENDOTHELINS; HUMANS; HYPERTENSION; INDOLES; MALE; METALLOENDOPEPTIDASES; PHOSPHONIC ACIDS; PROTEASE INHIBITORS; PROTEIN PRECURSORS; RATS; RATS, WISTAR; RECEPTOR, ENDOTHELIN A; RECEPTORS, ENDOTHELIN; TETRAZOLES;

EID: 0000319750     PISSN: 01602446     EISSN: None     Source Type: Journal    
DOI: 10.1097/00005344-199800001-00158     Document Type: Article

References (4)

1. Yanagisawa M, Kurihara H, Kimura S, et al. A novel potent vasoconstrictor peptide produced by vascular endothelial cells. Nature 1988;332:411-15.
2. Xu D, Emoto N, Giaid A, et al. ECE-1: a membrane-bound metalloprotease that catalyzes the proteolytic activation of big-endothelin-1. Cell 1994;78:473-85.
3. Levin ER. Endothelins. N Engl J Med 1995;333:356-63.
4. Niranjan V, Télémaque S, deWit D, et al. Systemic hypertension induced by hepatic overexpression of human preproendothelin-1 in rats. J Clin Invest 1996;98:2364-72.