Distributed neurodegenerative changes 2-28 days after ventral hippocampal excitotoxic lesions in rats

Brain Research

Volumn 873, Issue 1, 2000, Pages 60-74

  Halim, Nader D ^a   Swerdlow, Neal R ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Dopamine; Hippocampus; Ibotenic acid; Nucleus accumbens; Orbital cortex; Prepulse inhibition; Schizophrenia; Silver stain; Tyrosine hydroxylase

Indexed keywords

APOMORPHINE; IBOTENIC ACID; TYROSINE 3 MONOOXYGENASE;

ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN INJURY; BRAIN REGION; CONTROLLED STUDY; DOPAMINERGIC SYSTEM; DRUG HYPERSENSITIVITY; HIPPOCAMPUS; HISTOCHEMISTRY; IMMUNOCYTOCHEMISTRY; MALE; NERVE DEGENERATION; NONHUMAN; NUCLEUS ACCUMBENS; OLFACTORY BULB; ORBITAL CORTEX; PRIORITY JOURNAL; RAT; SEPTUM NUCLEUS; SUBSTANTIA NIGRA;

ANIMALS; CEREBRAL CORTEX; DOPAMINE; EFFERENT PATHWAYS; EXCITATORY AMINO ACID AGONISTS; HIPPOCAMPUS; IBOTENIC ACID; MALE; NERVE DEGENERATION; NERVE ENDINGS; OLFACTORY BULB; PROSENCEPHALON; RATS; RATS, SPRAGUE-DAWLEY; TIME FACTORS; TYROSINE 3-MONOOXYGENASE;

EID: 0034604820     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-8993(00)02497-5     Document Type: Article

References (69)

1. Bardgett M.E., Jackson J.L., Taylor G.T., Csernansky J.G. Kainic acid decreases hippocampal neuronal number and increases dopamine receptor binding in the nucleus accumbens: an animal model of schizophrenia. Behav. Brain Res. 70:1995;153-164.
2. Bogerts B. Recent advances in the neuropathology of schizophrenia. Schizophr. Bull. 19:1993;431-445.
3. Bogerts B., Ashtari M., Degreef G., Alvir J.M.J., Bilder R.M., Lieberman J.A. Reduced temporal limbic structure volumes on magnetic resonance images in first episode schizophrenia. Psychiatry Res. Neuroimag. 35:1990;1-13.
4. Bogerts B., Meertz E., Schonfeldt-Bausch R. Basal ganglia and limbic system pathology in schizophrenia. A morphometric study of brain volume and shrinkage. Arch. Gen. Psychiatry. 42:1985;784-791.
5. Bolino F., Di Michele V., Di Cicco L., Manna V., Daneluzzo E., Cassachia M. Sensorimotor gating and habituation evoked by electrocutaneous stimulation in schizophrenia. Biol. Psychiatry. 36:1994;670-679.
6. Braff D.L., Grillon C., Geyer M. Gating and habituation of the startle reflex in schizophrenic patients. Arch. Gen. Psychiatry. 49:1992;206-215.
7. Braff D., Stone C., Callaway E., Geyer M., Glick I., Bali L. Prestimulus effects on human startle reflex in normals and schizophrenics. Psychophysiology. 15:1978;339-343.
8. Braff D.L., Swerdlow N.R., Geyer M.A. Symptom correlates of prepulse inhibition deficits in male schizophrenic patients. Am. J. Psychiatry. 156:1999;596-602.
9. Brog J.S., Salyapongse A., Deutch A.Y., Zahm D.S. The patterns of afferent innervation of the core and shell in the 'accumbens' part of the rat ventral striatum: immunohistochemical detection of retrogradely transported fluoro-gold. J. Comp. Neurol. 338:1998;255-278.
10. Caine S.B., Geyer M.A., Swerdlow N.R. Hippocampal modulation of acoustic startle and prepulse inhibition in rats. Pharmacol. Biochem. Behav. 43:1992;1201-1208.
11. Carr D.B., Sesack S.R. Hippocampal afferents to the rat prefrontal cortex: synaptic targets and relation to dopamine terminals. J. Comp. Neurol. 369:1996;1-15.
12. Carr D.B., Sesack S.R. Terminals from the rat prefrontal cortex synapse on mesoaccumbens VTA neurons. Ann. NY Acad. Sci. 877:1999;676-678.
13. Carr D.B., O'Donnell P., Card J.P., Sesack S.R. Dopamine terminals in the rat prefrontal cortex synapse on pyramidal cells that project to the nucleus accumbens. J. Neurosci. 19:1999;11049-11060.
14. Castellanos F.X., Fine E.J., Kaysen D.L., Kozuch P.L., Hamburger S.D., Rapoport J.L., Hallett M. Sensorimotor gating in boys with Tourette's Syndrome and ADHD: preliminary results. Biol. Psychiatry. 39:1996;33-41.
15. Conrad A.J., Abebe T., Austin R., Forsythe S., Scheibel A.B. Hippocampal pyramidal cell disarray in schizophrenia as a bilateral phenomenon. Arch. Gen. Psychiatry. 48:1991;413-417.
16. Csernansky J.G., Kerr S., Pruthi R., Prosser E.S. Mesolimbic dopamine receptor increases two weeks after hippocampal kindling. Brain Res. 449:1988;357-360.
17. Csernansky J.G., Murphy G.M., Faustman W.O. Limbic/mesolimbic connections and the pathogenesis of schizophrenia. Biol. Psychiatry. 30:1993;383-400.
18. de Olmos J.S., Beltramino C.A., de Olmos de Lorenzo S. Use of an amino-cupric-silver technique for the detection of early and semiacute neuronal degeneration caused by neurotoxicants, hypoxia, and physical trauma. Neurotoxicol. Teratol. 16:1994;545-561.
19. Freedman R., Adler L.E., Myles-Worsley M., Nagamoto H.T., Miller C., Kisley M., McRae K., Cawthra E., Waldo M. Inhibitory gating of an evoked response to repeated auditory stimuli in schizophrenic and normal subjects. Human recordings, computer simulation, and an animal model. Arch. Gen. Psychiatry. 53:1996;1114-1121.
20. Geyer M.A., Braff D.L. Startle habituation and sensorimotor gating in schizophrenia and related animal models. Schizophr. Bull. 13:1987;643-668.
21. Grecksch G., Bernstein H.G., Becker A., Hollt V., Bogerts B. Disruption of latent inhibition in rats with postnatal hippocampal lesions. Neuropsychopharmacology. 20:1999;525-532.
22. Grillon C., Ameli R., Charney D.S., Krystal J., Braff D.L. Startle gating deficits occur across prepulse intensities in schizophrenic patients. Biol. Psychiatry. 32:1992;939-943.
23. Groenewegen H.J., Vermeulen-Van der Zee E., Te Kortschot A., Witter M.P. Organization of the projections from the subiculum to the ventral striatum in the rat. A study using anterograde transport of Phaseolus vulgaris leucoagglutinin. Neuroscience. 23:1987;103-120.
24. Halim N., Taaid N., Swerdlow N.R. Distributed neuropathology after excitotoxin lesions of ventral hippocampus. Biol. Psychiatry. 45:1999;30S.
25. Hamm A., Weike A., Bauer U., Vaitl D., Gallhofer B. Prepulse inhibition in medicated and unmedicated schizophrenics. Abstr. Soc. Psychophysiol. Res. 1995;. August.
26. Hart S., Zreik M., Carper R., Swerdlow N.R. Localizing haloperidol effects on sensorimotor gating in a predictive model of antipsychotic potency. Pharmacol. Biochem. Behav. 61:1998;113-119.
27. Hoffman H.S., Searle J.L. Acoustic and temporal factors in the evocation of startle. J. Acoust. Soc. Am. 43:1968;269-282.
28. Ison J.R., McAdam D.W., Hammond G.R. Latency and amplitude changes in the acoustic startle reflex produced by variations in auditory prestimulation. Physiol. Behav. 10:1973;1035-1039.
29. Kelley A.E., Domesick V.B. The distribution of the projection from the hippocampal formation to the nucleus accumbens in the rat: an anterograde- and retrograde-horseradish peroxidase study. Neuroscience. 7:1982;2321-2335.
30. Khaing Z.Z., Lipska B.K., Weickert C.S., Lerman D.N., Weinberger D.R. Evidence of cell death detected by in situ DNA fragmentation in rats with neonatal hippocampal lesions: a developmental profile. Soc. Neurosci. 23:1997;1711.
31. Klarner A., Koch M., Schnitzler H.U. Induction of fos-protein in the forebrain and disruption of sensorimotor gating following N-methyl-D-aspartate infusion into the ventral hippocampus of the rat. Neuroscience. 84:1998;443-452.
32. Koch M., Ebert U. Deficient sensorimotor gating following seizures in amygdala-kindled rats. Biol. Psychiatry. 44:1998;290-297.
33. Koch M., Schnitzler H.U. The acoustic startle response in rats - circuits mediating evocation, inhibition and potentiation. Behav. Brain Res. 89:1997;35-49.
34. Kodsi M., Swerdlow N.R. Quinolinic acid lesions of the ventral striatum reduce sensorimotor gating of acoustic startle in rats. Brain Res. 643:1994;59-65.
35. Kumari V., Soni W., Sharma T. Normalization of information processing deficits in schizophrenia with clozapine. Am. J. Psychiatry. 156:1999;1046-1051.
36. Lacosta S., Merali Z., Zalcman S., Anisman H. Time-dependent in vivo mesolimbic dopamine variations following antigenic challenge. Brain Res. 664:1994;225-230.
37. Liddle P., Friston K.J., Frith C.D., Hirsch S.R., Jones T., Frackowiak R.S. Patterns of cerebral blood flow in schizophrenia. Br. J. Psychiatry. 160:1992;179-186.
38. Lipska B.K., Al-Amin H.A., Khaing Z.Z., Lerman D.N., Lillrank S.M., Weinberger D.R. Effects of acute and chronic neuroleptic treatment on expression of D2 and D3 receptors, neurotensin and enkephalin mRNA in rats with neonatal lesions of the ventral hippocampus. Soc. Neurosci. 23:1997;1361.
39. Lipska B.K., Chrapusta S.J., Egan M.F., Weinberger D.R. Neonatal excitotoxic ventral hippocampal damage alters dopamine response to mild repeated stress and to chronic haloperidol. Synapse. 20:1995;125-130.
40. Lipska B.K., Swerdlow N.R., Geyer M.A., Jaskiw G.E., Braff D.L., Weinberger D.R. Neonatal excitotoxic hippocampal damage in rats causes post-pubertal changes in prepulse inhibition of startle and its disruption by apomorphine. Psychopharmacology. 122:1995;35-43.
41. Mansbach R.S., Geyer M.A., Braff D.L. Dopaminergic stimulation disrupts sensorimotor gating in the rat. Psychopharmacology. 94:1988;507-514.
42. Morton N., Gray N.S., Mellers J., Toone B., Lishman W.A., Gray J.A. Prepulse inhibition in temporal lobe epilepsy. EBPS. 1994;191. Abstract.
43. Paxinos G., Watson C. 2nd Edition The Rat Brain in Stereotaxic Coordinates. 1986;Academic Press, San Diego, CA.
44. Pouretemad H.R., Thompson P.J., Fenwick P.B.C. Impaired sensorimotor gating in patients with non-epileptic seizures. Epilepsy Res. 31:1998;1-12.
45. Reijmers L.G., Vanderheyden P.M., Peeters B.W. Changes in prepulse inhibition after local administration of NMDA receptor ligands in the core region of the rat nucleus accumbens. Eur. J. Pharmacol. 272:1995;131-138.
46. Seeman P., Ulpian C., Bergeron C., Riederer P., Jellinger K., Babriel E., Reynolds G., Tourtellotte W. Bimodal distribution of dopamine receptor densities in brain of schizophrenics. Science. 225:1984;728-731.
47. Sesack S.R., Pickel V.M. In the rat medial nucleus accumbens, hippocampal and catecholaminergic terminals converge on spiny neurons and are in apposition to each other. Brain Res. 527:1990;266-279.
48. Seybold K.S., Smith K., Wrigley J., Port R.L. Diminished prepulse inhibition following kainic acid-induced hippocampal damage to model schizophrenic neuropathology. Abstr. Soc. Neurosci. 21:1995;746.
49. Shenton M.E., Kikinis R., Jolesz F.A., Pollak S.D., LeMay M., Wible C.G., Hokama H., Martin J., Metcalf D., Coleman M. Abnormalities of the left temporal lobe and thought disorder in schizophrenia. N. Engl. J. Med. 327:1992;604-612.
50. Suddath R.L., Christison M.D., Torrey E.F., Cassanova M., Weinberger D.R. Anatomic abnormalities in the brains of monozygotic twins discordant for schizophrenia. N. Engl. J. Med. 322:1990;789-794.
51. Swerdlow N.R. Neuropsychology of schizophrenia: the 'hole' thing is wrong. Behav. Brain Sci. 14:1991;51-53.
52. Swerdlow N.R., Braff D.L., Taaid N., Geyer M.A. Assessing the validity of an animal model of sensorimotor gating deficits in schizophrenic patients. Arch. Gen. Psychiatry. 51:1994;139-154.
53. Swerdlow N.R., Geyer M.A. Clozapine and haloperidol in an animal model of sensorimotor gating deficits in schizophrenia. Pharmacol. Biochem. Behav. 44:1993;741-744.
54. Swerdlow N.R., Geyer M.A. Neurophysiology and neuropharmacology of short lead interval startle modification. Dawson M.E., Schell A., Boehmelt A. Startle Modification: Implications for Neuroscience, Cognitive Science, and Clinical Science. 1999;114-133 Cambridge University Press, Cambridge, UK.
55. Swerdlow N.R., Taaid N., Halim N., Randolph E., Kim Y.K., Auerbach P. Hippocampal lesions enhance startle gating-disruptive effects of apomorphine in rats: a parametric assessment. Neuroscience. 2000;. In press.
56. Swerdlow N.R., Lipska B.K., Weinberger D.R., Braff D.L., Jaskiw G.E., Geyer M.A. Increased sensitivity to the gating-disruptive effects of apomorphine after lesions of the medial prefrontal cortex or ventral hippocampus in adult rats. Psychopharmacology. 122:1995;27-34.
57. Swerdlow N.R., Taaid N., Randolph E., Halim N., Geyer M.A. Hippocampus lesion and dopamine agonist effects on startle gating: parametric studies. Biol. Psychiatry. 45:1999;14-15S.
58. Totterdell S., Smith A.D. Convergence of hippocampal and dopaminergic input onto identified neurons in the nucleus accumbens of the rat. J. Chem. Neuroanat. 2:1995;285.
59. Wan F.J., Caine S.B., Swerdlow N.R. The ventral subiculum modulation of prepulse inhibition is not mediated via D2 dopamine or nucleus accumbens non-NMDA glutamate activity. Eur. J. Pharmacol. 314:1996;9-18.
60. Wan F.J., Geyer M.A., Swerdlow N.R. Accumbens D2 substrates of sensorimotor gating: assessing anatomical localization. Pharmacol. Biochem. Behav. 49:1994;155-263.
61. Wan F.J., Geyer M.A., Swerdlow N.R. Presynaptic dopamine-glutamate interactions in the nucleus accumbens regulate sensorimotor gating. Psychopharmacology. 120:1995;433-441.
62. Wan F.J., Swerdlow N.R. Sensorimotor gating in rats is regulated by different dopamine-glutamate interactions in the nucleus accumbens core and shell subregions. Brain Res. 722:1996;168-176.
63. Wan F.J., Taaid N., Swerdlow N.R. Do D1/D2 interactions regulate prepulse inhibition in rats? Neuropsychopharmacology. 14:1996;265-274.
64. Wan R.Q., Corbett R. Enhancement of postsynaptic sensitivity to dopaminergic agonists induced by neonatal hippocampal lesions. Neuropsychopharmacology. 16:1997;259-268.
65. Weinberger D.R. Implications of normal brain development for the pathogenesis of schizophrenia. Arch. Gen. Psychiatry. 44:1987;660-669.
66. Wong D., Wagner H., Tune L., Dannals R., Pearlson G., Links J., Tamminga C., Broussolle E., Ravert H., Wilson A., Toung J., Malat J., Williams J., O'Tuama L., Snyder S., Kuhar M., Gjedde A. Positron emission tomography reveals elevated D2 dopamine receptors in drug-naive schizophrenics. Science. 234:1986;1558-1563.
67. Wu J.C., Potkin S.G., Ploszaj D.I. Clozapine improves sensory gating more than haldol. Am. Psychiatr. Assoc. 1992;156. Abstract.
68. Yamada S., Harano M., Tanaka M. Dopamine autoreceptors in rat nucleus accumbens modulate prepulse inhibition of acoustic startle. Pharmacol. Biochem. Behav. 64:1998;803-808.
69. Zavitsanou K., Cranney J., Richardson R. Dopamine antagonists in the orbital prefrontal cortex reduce prepulse inhibition of the acoustic startle response in rats. Pharmacol. Biochem. Behav. 63:1999;55-61.