Fate of the 2'-deoxyadenosin-5'-yl radical under anaerobic conditions [7]

Journal of the American Chemical Society

Volumn 122, Issue 17, 2000, Pages 4225-4226

  Flyunt, Roman ^a,b   Bazzanini, Rita ^a   Chatgilialoglu, Chryssostomos ^a   Mulazzani, Quinto G ^a  

^a CNR   (Italy)

^b INSTITUTE OF HYDROBIOLOGY   (Ukraine)

Author keywords

[No Author keywords available]

Indexed keywords

FREE RADICAL;

ANAEROBIC METABOLISM; CHEMICAL REACTION; CYCLIZATION; LETTER; OXIDATIVE STRESS; SYNTHESIS;

EID: 0034600334     PISSN: 00027863     EISSN: None     Source Type: Journal    
DOI: 10.1021/ja9941577     Document Type: Letter

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27. Similar reactions were observed in the case of bromouracil derivatives, see; Adams, G. E.; Willson, R. L. Int. J. Radiat. Biol. 1972, 22, 589. Patterson, L. K.; Bansal, K. M. J. Phys. Chem. 1972, 76, 2392. Bansal, K. M.; Patterson, L. K.; Schuler, R. H. J. Phys. Chem. 1972, 76, 2386. Bhatia, K.; Schuler, R. H. J. Phys. Chem. 1973, 77, 1888. Wagner, B. O.; Klever, H.; Schulte- Frohlinde, D. Z. Naturforsch. 1974, 28b, 86. Rivera, E.; Schuler, R. H. J. Phys. Chem. 1983, 87, 3966.
28. Similar reactions were observed in the case of bromouracil derivatives, see; Adams, G. E.; Willson, R. L. Int. J. Radiat. Biol. 1972, 22, 589. Patterson, L. K.; Bansal, K. M. J. Phys. Chem. 1972, 76, 2392. Bansal, K. M.; Patterson, L. K.; Schuler, R. H. J. Phys. Chem. 1972, 76, 2386. Bhatia, K.; Schuler, R. H. J. Phys. Chem. 1973, 77, 1888. Wagner, B. O.; Klever, H.; Schulte- Frohlinde, D. Z. Naturforsch. 1974, 28b, 86. Rivera, E.; Schuler, R. H. J. Phys. Chem. 1983, 87, 3966.
29. Similar reactions were observed in the case of bromouracil derivatives, see; Adams, G. E.; Willson, R. L. Int. J. Radiat. Biol. 1972, 22, 589. Patterson, L. K.; Bansal, K. M. J. Phys. Chem. 1972, 76, 2392. Bansal, K. M.; Patterson, L. K.; Schuler, R. H. J. Phys. Chem. 1972, 76, 2386. Bhatia, K.; Schuler, R. H. J. Phys. Chem. 1973, 77, 1888. Wagner, B. O.; Klever, H.; Schulte- Frohlinde, D. Z. Naturforsch. 1974, 28b, 86. Rivera, E.; Schuler, R. H. J. Phys. Chem. 1983, 87, 3966.
30. Similar reactions were observed in the case of bromouracil derivatives, see; Adams, G. E.; Willson, R. L. Int. J. Radiat. Biol. 1972, 22, 589. Patterson, L. K.; Bansal, K. M. J. Phys. Chem. 1972, 76, 2392. Bansal, K. M.; Patterson, L. K.; Schuler, R. H. J. Phys. Chem. 1972, 76, 2386. Bhatia, K.; Schuler, R. H. J. Phys. Chem. 1973, 77, 1888. Wagner, B. O.; Klever, H.; Schulte- Frohlinde, D. Z. Naturforsch. 1974, 28b, 86. Rivera, E.; Schuler, R. H. J. Phys. Chem. 1983, 87, 3966.
31. Similar reactions were observed in the case of bromouracil derivatives, see; Adams, G. E.; Willson, R. L. Int. J. Radiat. Biol. 1972, 22, 589. Patterson, L. K.; Bansal, K. M. J. Phys. Chem. 1972, 76, 2392. Bansal, K. M.; Patterson, L. K.; Schuler, R. H. J. Phys. Chem. 1972, 76, 2386. Bhatia, K.; Schuler, R. H. J. Phys. Chem. 1973, 77, 1888. Wagner, B. O.; Klever, H.; Schulte-Frohlinde, D. Z. Naturforsch. 1974, 28b, 86. Rivera, E.; Schuler, R. H. J. Phys. Chem. 1983, 87, 3966.
32. Similar reactions were observed in the case of bromouracil derivatives, see; Adams, G. E.; Willson, R. L. Int. J. Radiat. Biol. 1972, 22, 589. Patterson, L. K.; Bansal, K. M. J. Phys. Chem. 1972, 76, 2392. Bansal, K. M.; Patterson, L. K.; Schuler, R. H. J. Phys. Chem. 1972, 76, 2386. Bhatia, K.; Schuler, R. H. J. Phys. Chem. 1973, 77, 1888. Wagner, B. O.; Klever, H.; Schulte- Frohlinde, D. Z. Naturforsch. 1974, 28b, 86. Rivera, E.; Schuler, R. H. J. Phys. Chem. 1983, 87, 3966.
33. 19
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37. Chemical radiation studies of 8-bromoguanosine in aqueous solutions have shown that it behaves in a completely different manner, see: Ioele, M.; Bazzanini, R.; Chatgilialoglu, C.; Mulazzani, Q. G. J. Am. Chem. Soc. 2000, 122, 1900.
38. Chatgilialoglu, C. In Handbook of Organic Photochemistry; Scaiano, J. C., Ed.; CRC Press: Boca Raton, 1989; Vol. 2; pp 3-11.
39. -1. It is worth pointing out that in the steady-state experiments the stationary concentrations of the radicals are a few orders of magnitude lower compared to those of the pulse radiolysis.
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44. (b) The intracellular level of glutathione in mammalian cells is in the 0.5-10 mM range, see: Meister, A.; Anderson, M. E. Annu. Rev. Biochem. 1983, 52, 711.
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