Syntheses and evaluation of naphthalenyl- and chromenyl-pyrrol-benzoic acids as potent and selective retinoic acid receptor α agonists

Bioorganic and Medicinal Chemistry Letters

Volumn 10, Issue 7, 2000, Pages 623-625

  Hibi, Shigeki ^a   Tagami, Katsuya ^a   Kikuchi, Kouichi ^a   Yoshimura, Hiroyuki ^a   Tai, Kenji ^a   Hida, Takayuki ^a   Tokuhara, Naoki ^a   Yamauchi, Toshihiko ^a   Nagai, Mitsuo ^a  

^a EISAI CO LTD   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

4 [5 (5,8 DIMETHYL 2H 3 CHROMENYL) 1H 2 PYRROLYL]BENZOIC ACID; 5,6,7,8 TETRAMETHYLNAPHTHALENE DERIVATIVE; 5,7 DIMETHYLNAPHTHALENE DERIVATIVE; 5,8 DIMETHYLNAPHTHALENE DERIVATIVE; 8 ISOPROPYLNAPHTHALENE DERIVATIVE; 8 PHENYLNAPHTHALENE DERIVATIVE; BENZOPYRAN DERIVATIVE; NAPHTHALENE DERIVATIVE; RETINOIC ACID; RETINOIC ACID RECEPTOR; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; CELL STRAIN HL 60; CHEMICAL MODIFICATION; DRUG POTENCY; DRUG RECEPTOR BINDING; DRUG SYNTHESIS; HUMAN; HUMAN CELL; STRUCTURE ACTIVITY RELATION; TRANSACTIVATION;

BENZOIC ACIDS; BENZOPYRANS; CELL DIFFERENTIATION; HL-60 CELLS; HUMANS; NAPHTHALENES; PYRROLES; RECEPTORS, RETINOIC ACID; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0034599813     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(00)00067-6     Document Type: Article

References (9)

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8. 6 from 4a (overall yield 33%).
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