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Volumn 39, Issue 9, 2000, Pages 1629-1632

An enzyme-labile safety catch linker for combinatorial synthesis on a soluble polymeric support

Author keywords

Combinatorial chemistry; Enzyme catalysis; Hydrolases; Solid phase synthesis

Indexed keywords

ENZYME; POLYMER;

EID: 0034595324     PISSN: 14337851     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1521-3773(20000502)39:9<1629::AID-ANIE1629>3.0.CO;2-E     Document Type: Article
Times cited : (38)

References (36)
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    • Enzyme-labile linker groups for syntheses on solid supports, see: a) B. Sauerbrei, V. Jungmann, H. Waldmann, Angew. Chem. 1998, 110, 1187-1190; Angew. Chem. Int. Ed. 1998, 37, 1143-1146, and references therein; b) G. Böhm, J. Dowden, D. C. Rice, I. Burgess, J.-F. Pilard, B. Guilbert, A. Haxton, R. C. Hunter, N. J. Turner, S. L. Flitsch, Tetrahedron Lett. 1998, 39, 3819-3822. Safety catch linkers for combinatorial synthesis, see examples in: c) N. J. Osborn, J. A. Robinson, Tetrahedron 1993, 49, 2873-2884; d) X.-Y. Xiao, M. P. Nova, A. W. Czarnik, J. Comb. Chem. 1999, 1, 379-382.
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    • For the use of the PhAc group in the deprotection of peptides, carbohydrates and nucleosides. see: a) H. Waldmann, Liebigs. Ann. Chem. 1988, 1175-1180, and references therein; b) H. Waldmann, A. Heuser, A. Reidel, Synlett 1994, 65-67; c) M. A. Dineva, B. Galunsky, V. Kasche, D. D. Petkov, Bioorg. Med. Chem. Lett. 1993, 3, 2781-2784; d) H. Waldmann, A. Reidel, Angew. Chem. 1997, 109, 642-644; Angew. Chem. Int. Ed. Engl. 1997, 36, 647-649.
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    • For the use of the PhAc group in the deprotection of peptides, carbohydrates and nucleosides. see: a) H. Waldmann, Liebigs. Ann. Chem. 1988, 1175-1180, and references therein; b) H. Waldmann, A. Heuser, A. Reidel, Synlett 1994, 65-67; c) M. A. Dineva, B. Galunsky, V. Kasche, D. D. Petkov, Bioorg. Med. Chem. Lett. 1993, 3, 2781-2784; d) H. Waldmann, A. Reidel, Angew. Chem. 1997, 109, 642-644; Angew. Chem. Int. Ed. Engl. 1997, 36, 647-649.
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    • The polymer was heated to boiling in a 1 % aqueous ninhydrin solution without development of any colour
    • The polymer was heated to boiling in a 1 % aqueous ninhydrin solution without development of any colour.


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