Enhanced antisense efficacy of oligonucleotides adsorbed to monomethylaminoethylmethacrylate methylmethacrylate copolymer nanoparticles

European Journal of Pharmaceutics and Biopharmaceutics

Volumn 49, Issue 3, 2000, Pages 203-210

  Zobel, Hans Peter ^a   Junghans, Monika ^a   Maienschein, Vera ^c   Werner, Doris ^b   Gilbert, Matthias ^b   Zimmermann, Herbert ^c   Noe, Christian ^b   Kreuter, Jörg ^a   Zimmer, Andreas ^a  

^a Inst fur Pharmazeut Technol   (Germany)

^b Inst für Pharmazeut Chemie   (Germany)

^c Department of Life Sciences   (Germany)

Author keywords

Aminoalkylmethacrylate; Antisense oligonucleotide; Cell penetration; Ecto 5' nucleotidase; Nanoparticle; PC12 cell

Indexed keywords

ANTISENSE OLIGONUCLEOTIDE; COPOLYMER; FLUORESCENT DYE; METHACRYLIC ACID METHYL ESTER; METHACRYLIC ACID METHYLAMINOETHYL ESTER; NANOPARTICLE; PHOSPHODIESTERASE I; POLYMETHACRYLIC ACID DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL CULTURE; CELL STRAIN; CELLULAR DISTRIBUTION; CONTROLLED STUDY; DRUG ADSORPTION; DRUG DELIVERY SYSTEM; DRUG SYNTHESIS; ENZYME ACTIVITY; IMMUNOCYTOCHEMISTRY; IN VITRO STUDY; NONHUMAN; POLYMERIZATION; PROTEIN EXPRESSION;

5'-NUCLEOTIDASE; ADSORPTION; ANIMALS; IMMUNOHISTOCHEMISTRY; METHACRYLATES; MICROSPHERES; OLIGONUCLEOTIDES, ANTISENSE; PC12 CELLS; POLYMERS; RATS;

EID: 0034595215     PISSN: 09396411     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0939-6411(00)00080-1     Document Type: Article

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