Dynorphins are endogenous opioid peptides released from granule cells to act neurohumorly and inhibit excitatory neurotransmission in the hippocampus

Progress in Brain Research

Volumn 125, Issue , 2000, Pages 363-367

  Chavkin, Charles ^a  

^a UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTICONVULSIVE AGENT; DYNORPHIN; KAPPA OPIATE RECEPTOR AGONIST; NEUROHORMONE; OPIATE PEPTIDE; POTASSIUM CHANNEL;

ANTICONVULSANT ACTIVITY; CONFERENCE PAPER; DENDRITE; EPILEPSY; GRANULE CELL; HIPPOCAMPUS; HORMONE RECEPTOR INTERACTION; HORMONE RELEASE; LONG TERM POTENTIATION; MOSSY FIBER; NEUROPROTECTION; NEUROTRANSMISSION; NONHUMAN; POTASSIUM CONDUCTANCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; SECOND MESSENGER; SIGN TEST; SYNAPTIC POTENTIAL;

EID: 0034589153     PISSN: 00796123     EISSN: None     Source Type: Book Series    
DOI: 10.1016/S0079-6123(00)25025-5     Document Type: Conference Paper

References (31)

1. Bausch, S.B., Esteb, T.M., Terman, G.W. and Chavkin, C. (1998) Administered and endogenously released kappa opioids decrease pilocarpine-induced seizures and seizureinduced histopathology. J. Pharmacol. Exp. Ther., 248: 1147-1155.
2. Chavkin, C., Bakhit, C., Weber, E. and Bloom, F.E. (1983) Relative contents and concomitant release of prodynorphin/neoendorphin-derived peptides in rat hippocampus. Proc. Natl. Acad. Sci., 80: 7669-7673.
3. Chavkin, C., James, I.F. and Goldstein, A. (1982) Dynorphin is a specific endogenous ligand of the kappa opioid receptor. Science 215: 413-415.
4. Chavkin, C., Shoemaker, W., McGinty, J. Bayon, A. and Bloom, F.E. (1985) Characterization of the prodynorphin and proenkephalin neuropeptides systems in rat hippocampus. J. Neurosci., 5: 808-816.
5. Cheramy, A., Leviel, V. and Glowinski, J. (1981) Dendritic release of dopamine in the substantia nigra. Nature, 289: 537-542
6. Cottrell, G.A. (1993) The wide range of actions of the FMRFamide-related peptides and the biological importance of peptidergic messengers. EXS, 63: 279-285.
7. Drake, C., Patterson, T.A., Simmons, M.L., Chavkin, C. and Milner, T. (1996) Kappa opioid receptor-like immunoreactivity in guinea pig brain: Ultrastructural localization in presynaptic terminals in hippocampal formation. J. Comp. Neurol., 370: 377-397.
8. Drake, C., Terman, G.W., Simmons, M.L., Kunkel, D., Milner, T., Schwartzkroin, P.A. and Chavkin, C. (1994) Dynorphin opioids present in dentate granule cells may function as a retrograde inhibitory neurotransmitters, J. Neurosci., 14: 3736-3750.
9. Gallagher, M. and Nicolle, M.M. (1993) Animal models of normal aging: Relationship between cognitive decline and markers in hippocampal circuitry. Behav. Brain Res., 57: 155-162.
10. Hawkins, R.D., Kandel, E.R. and Siegelbaum, S.A. (1993) Learning to modulate transmitter release: Themes and variations in synaptic plasticity. Annu Rev. Neurosci., 16: 625-665.
11. Jan, L.Y. and Jan, Y.N. (1982). Peptidergic transmission in sympathetic ganglia of the frog. J. Physiol., 327: 219-246.
12. Katz, B. (1966) Nerve, Muscle, and Synapse. McGraw-Hill, New York.
13. Kieffer, B.L. (1995) Recent advances in molecular recognition and signal transduction of active peptides: Receptors for opioid peptides. Cell Mol. Neurobiol., 15: 615-635.
14. Kuffler, S.W. and Nicholls, J.G. (1976) From Neuron to Brain, Sinauer Associates, Sunderland, Massachusetts, pp. 216.
15. McGinty, J.F., Henriksen, S.J., Goldstein, A., Terenius, L. and Bloom, F.E. (1983) Dynorphin is contained within hippocampal mossy fibers: Immunochemical alterations after kainic acid administration and colchicine-induced neurotoxicity. Proc. Natl. Acad. Sci., 80: 589-593.
16. Pow, D.V. and Morris, J.F. (1989) Dendrites of hypothalamic magnocellular neurons release neurohypophysial peptides by exocytosis. Neuroscience, 32: 435-439.
17. Przewlocka, B., Machelska, H. and Lason, W. (1994) Kappa opioid receptor agonists inhibit the pilocarpine-induced seizures and toxicity in the mouse. Eur. Neuropsychopharmacol. 4: 527-533.
18. Simmons, M.L. and Chavkin, C. (1996) Kappa opioid receptor activation of a dendrotoxin-sensitive potassium channel mediates presynaptic inhibition of mossy fiber neurotransmitter release. Mol. Pharmacol., 50: 80-85.
19. Simmons, M.L., Drake, C.T., Terman, G.W. and Chavkin, C. (1994) Inhibition of glutamate release by presynaptic kappal opioid receptors in the guinea pig dentate gyrus. J. Neurophysiol., 72: 1697-1705.
20. Simmons, M.L., Terman, G.W., Gibbs, S.M. and Chavkin, C. (1995) L-type calcium channel types mediate dynorphin neuropeptide release from dendrites but not axons of hippocampal granule cells. Neuron 14: 1265-1272.
21. Simmons, M.L., Terman, G.W. and Chavkin, C. (1997) Spontaneous excitatory currents and kappa opioid receptor inhibition in dentate gyrus are increased in the rat pilocarpine model of temporal lobe epilepsy. J. Neurophysiol., 78: 1860-1868.
22. Simonato, M. and Romualdi, P. (1996) Dynorphin and epilepsy. Prog. Neurobiol., 50: 557-583.
23. Terman, G.W., Wagner, J.J. and Chavkin, C. (1994) Kappa opioids inhibit induction of long-term potentiation in the dentate gyrus of the guinea pig hippocampus. J. Neurosci., 14: 4740-4747.
24. Terman, G.W., Drake, C.T, Simmons, M.L., Milner, T.A. and Chavkin, C. (2000) Opioid modulation of recurrent excitation in the dentate gyrus of the guinea pig hippocampus. J. Neuroscience (in press).
25. Tortella, F.C. and DeCoster, M.A. (1994) Kappa opioids: Therapeutic considerations in epilepsy and CNS injury. Clin. Neuropharmacol., 17: 403-416.
26. Vaughan, C.W., Ingram, S.L., Connor, M.A. and Christie, M.J. (1997) How opioids inhibit GABA-mediated neurotransmission. Nature, 390: 611-614.
27. Wagner, J.J., Evans, C.J. and Chavkin, C. (1991) Focal stimulation of the mossy fibers releases endogenous dynorphins that bind kappal opioid receptors in the guinea pig hippocampus. J. Neurochem., 57: 333-343.
28. Wagner, J.J., Caudle, R.M. and Chavkin, C. (1992) Kappa opioids decrease excitatory transmission in the dentate gyrus of the guinea pig hippocampus. J. Neurosci., 12: 132-141.
29. Wagner, J.J., Terman, G.W. and Chavkin, C. (1993) Endogenous dynorphins inhibit excitatory neurotransmission and block long term potentiation in the hippocampus. Nature, 363: 451-454.
30. Weisskopf, M.G., Zalutsky, R.A. and Nicoll, R.A. (1993) The opioid peptide dynorphin mediates heterosynaptic depression of hippocampal mossy fibre synapses and modulates longterm potentiation. Nature, 362: 423-427.
31. Zhang, N. and Houser, C.R.J. (1999) Ultrastructural localization of dynorphin in the dentate gyrus in human temporal lobe epilepsy: A study of reorganized mossy fiber synapses. Comp. Neurol., 405: 472-490.