Derivatization of protonated peptides via gas phase ion-molecule reactions with acetone

Journal of the American Society for Mass Spectrometry

Volumn 11, Issue 3, 2000, Pages 244-256

  O'Hair, Richard A J ^a   Reid, Gavin E ^a  

^a UNIVERSITY OF MELBOURNE   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

MASS SPECTROMETRY;

ION-MOLECULE REACTIONS;

ACETONE;

ACETONE; GLYCINE; PEPTIDE;

MASS SPECTROMETRY;

DERIVATIZATION; DISSOCIATION; ENERGY; IONIZATION; PEPTIDE ANALYSIS; PRECURSOR; PROTON TRANSPORT; REACTION ANALYSIS; REVIEW; SEQUENCE ANALYSIS; TANDEM MASS SPECTROMETRY;

EID: 0034582457     PISSN: 10440305     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1044-0305(99)00142-7     Document Type: Article

References (63)

1. A Method for the determination of the amino acid sequence in peptides
2. A new method for sequencing DNA
3. Review. Chemical procedures for C-terminal sequencing of peptides and proteins
4. Cleavage at cysteine after cyanylation
5. Cleavage at Asn-Gly bonds with hydroxylamine
6. Cleavage at tryptophan with o-iodosobenzoic acid
7. Cleavage at aspartic acid
8. Specific cleavage of amino side chains of serine and threonine in peptides and proteins with S-ethyltrifluorothioacetate vapor
9. Bond-specific chemical cleavages of peptides and proteins with perfluoric acid vapors; Novel peptide bond cleavages of glycyl-threonine, the amino side of serine residues and the carboxyl side of aspartic acid residues
10. Optimization by mass spectrometry of a tryptophan-specific protein cleavage reaction
11. Molecular characterization of surface topology in protein tertiary structures by amino-acylation and mass spectrometric peptide mapping
12. Protein surface topology-probing by selective chemical modification and mass spectrometric peptide mapping
13. In vivo footprinting using N-ethyl, N-nitrosourea; Improved resolution of the DNA-protein interactions in the human gamma-globin gene promoter region
14. Footprinting protein-DNA complexes in vivo
15. Laser desorption ionization of proteins with molecular masses exceeding 10,000 daltons
16. Electrospray ionization for mass spectrometry of large biomolecules
17. Chemical derivatization for mass spectrometry
18. Derivatization in mass spectrometry; Strategies for controlling fragmentation
19. Charge state assignment from Schiff-Base adducts in low resolution electrospray mass spectra of protein mixtures and dissociation products
20. Electrospray mass spectrometric study of protein-ketone equilibria in solution
21. C-terminal sequencing of protein-A novel partial acid hydrolysis and analysis by mass spectrometry
22. Protein ladder sequencing
23. Peptide ladder sequencing by mass spectrometry using a novel, volatile degradation reagent
24. Promotion and stabilization of b1 ions in peptide phenylthiocarbamoyl derivatives; Analogies with condensed-phase chemistry
25. Simplification of high-energy collision spectra of peptides by amino-terminal derivatization
26. On-line derivatization of peptides for improved analysis by microcolumn liquid chromatography coupled with electrospray ionization-tandem mass spectrometry
27. A novel derivatization method with 5-bromonicotinic acid N-hydroxysuccinimide for determination of the amino acid sequences of peptides
28. Gas phase ion-molecule reactions in a modified ion trap; H/D exchange of non-covalent complexes and coordinatively unsaturated platinum complexes
29. Probing the fragmentation reactions of protonated glycine oligomers via multistage mass spectrometry and gas phase H/D exchange in a modified ion trap
30. The gas-phase basicities and proton affinities of amino acids and peptides
31. Proton Transfer Reactivity of Large Multiply Charged Ions
32. Ion-molecule reactions as probes of gas-phase structures of peptides and proteins
33. The bimolecular gas-phase reaction of protonated alkyldipeptides with acetonylacetone
34. Gaseous protein cations are amphoteric
35. Counting basic sites in oligopeptides via gas-phase chemistry
36. The methoxymethyl cation cleaves peptide bonds in the gas phase
37. Trimethylsilyl derivatization of nucleic acid anions in the gas phase
38. Ion-molecule reactions of simple amines with carbonyl compounds in the gas phase. An experimental and theoretical study of enamine formation
39. Structures of the adduct ions formed in the ammonia chemical ionization of ketones
40. Methods of formation of the carbon-nitrogen double bond
41. The structures of acetone-oxytocin with studies on the reactions of acetone with various peptides
42. The detection of a Schiff base intermediate in the formation of acetone-oxytocin
43. N,N′-Alkylidenpeptide; Peptidsynthese-nebenprodukte bei einwirkung von carbonylverbindungen
44. Modification of proteins and other biological molecules by acetaldehyde; Adduct structure and significance
45. The condensation of aldehydes and ketones with dipeptides
46. Reductive alkylation of amino groups
47. Protein labelling by reductive alkylation
48. A mass spectrometric and ab initio study of the pathways for dehydration of simple glycine and cysteine-containing peptide [M + H] + ions
49. Role of the sulfhydryl group on the gas phase fragmentation reactions of protonated cysteine and cysteine containing peptides
50. Harmonic vibrational frequencies; An evaluation of Hartree-Fock, Moller-Plesset, quadratic configuration interaction, density functional theory, and semiemperical scale factors
51. Influence of peptide composition, gas-phase basicity, and chemical modification of fragmentation efficiency; Evidence for the mobile proton model
52. Salt bridge structures in the absence of solvent? The case for the oligoglycines
53. Evaluated gas phase basicities and proton affinities of molecules; An update
54. Proton affinities and the sites of protonation of enamines in the gas phase
55. The b1-fragment ion from protonated glycine is an electrostatically-bound ion/molecule complex of CH2=NH2+ and CO
56. Why are B ions stable species in peptide spectra?
57. The structure and fragmentation of Bn (n equal to or greater than 3) ions in peptide spectra
58. Formation of b2+ ions from protonated peptides; An ab initio study
59. Experimental and ab initio studies of the gas-phase basicities of polyglycines
60. Experimental and ab initio studies on protonations of alanine and small peptides of alanine and glycine