Intercellular adhesion molecule–1 (ICAM–1) mediated gene delivery to rheumatoid synovial cells using the Fab fragments of anti-ICAM-1 monoclonal antibody

Japanese Journal of Clinical Immunology

Volumn 23, Issue 6, 2000, Pages 533-537

  Saito, Kazuyoshi ^a   Fujii, Koichi ^a   Awazu, Yuichiro ^a   Nakayamada, Shingo ^a   Nakano, Kazuhisa ^a   Aso, Megumi ^a   Tanaka, Yoshiya ^a   Ota, Toshiyuki ^b  

^a UNIVERSITY OF OCCUPATIONAL AND ENVIRONMENTAL HEALTH   (Japan)

^b School of Medicine   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

DNA; INTERCELLULAR ADHESION MOLECULE 1; MONOCLONAL ANTIBODY;

ARTICLE; CYTOLOGY; GENE THERAPY; GENE VECTOR; HUMAN; IMMUNOLOGY; METHODOLOGY; RHEUMATOID ARTHRITIS; SYNOVIUM;

ANTIBODIES, MONOCLONAL; ARTHRITIS, RHEUMATOID; DNA; GENE THERAPY; GENETIC VECTORS; HUMANS; INTERCELLULAR ADHESION MOLECULE-1; SYNOVIAL MEMBRANE;

EID: 0034577710     PISSN: 09114300     EISSN: 13497413     Source Type: Journal    
DOI: 10.2177/jsci.23.533     Document Type: Article

References (11)

1. Tanaka, Y., Morimoto, I., Nakano, Y., Okada, Y., Hirota, S., Nomura, S., Nakamura, T., Eto, S.: Osteoblasts are regulated by the cellular adhesion through ICAM-1 and VCAM-1. J. Bone. Miner. Res., 10: 1462~1469, 1995.
2. Koyama, Y., Tanaka, Y., Saito, K., Abe, M., Nakatsuka, K., Morimoto, I., Auron, P.E., Eto, S.: Cross-linking of intercellular adhesion molecule 1 (CD 54) induces AP-1 activation and IL-1 beta transcription. J. Immunol., 157: 5097–5103, 1996.
3. Nakatsuka, K., Tanaka, Y., Hubscher, S., Abe, M., Wake, A., Saito, K., Morimoto, I., Eto, S.: Rheumatoid synovial fibroblasts are stimulated by the cellular adhesion to T cells through lymphocyte function associated antigen-l/intercellular adhesion molecule-1. J. Rheumatol., 24: 458–264, 1997.
4. Kavanaugh, A.F., Davis, L.S., Nichols, L.A., Norris, S.H., Rothlein, R., Scharschmidt, L. A., Lipsky, P.E.: Treatment of refractory rheumatoid arthritis with a monoclonal antibody to intercellular adhesion molecule 1. Arthritis. Rheum., 37: 992~999, 1994.
5. Kavanaugh, A.F., Davis, L.S., Jain, R.I., Nichols, L.A., Norris, S.H., Lipsky, P.E.: Phase 1/II open label study of the safety and efficacy of an anti-ICAM-1 (intercellular adhesion molecule-1 ; CD 54) monoclonal antibody in early rheumatoid arthritis. J. Rheumatol., 23: 1338~1344, 1996.
6. Kavanaugh, A.F., Schulze, Koops, H., Davis, L.S., Lipsky, P.E.: Repeat treatment of rheumatoid arthritis patients with a murine anti-intercellular adhesion molecule 1 monoclonal antibody. Arthritis. Rheum., 40: 849~853, 1997.
7. Chen, J., Gamou, S., Takayanagi, A., Shimizu, N.: A novel gene delivery system using EGF receptor-mediated endocytosis. FEBS. Lett., 338: 167~169, 1994.
8. Shimizu, N., Chen, J., Gamou, S., Takayanagi, A.: Immunogene approach toward cancer therapy using erythrocyte growth factor receptor-mediated gene delivery. Cancer. Gene. Ther., 3: 113–120, 1996.
9. Chen, J., Gamou, S., Takayanagi, A., Ohtake, Y., Ohtsubo, M., Shimizu, N.: Targeted in vivo delivery of therapeutic gene into experimental squamous cell carcinomas using antiepidermal growth factor receptor antibody: immunogene approach. Hum. Gene. Ther., 9: 2673–2681, 1998.
10. Chen, J., Gamou, S., Takayanagi, A., Ohtake, Y., Ohtsubo, M., Shimizu, N.: Receptormediated gene delivery using the Fab fragments of anti-epidermal growth factor receptor antibodies: improved immunogene approach. Cancer. Gene. Ther., 5: 357~364, 1998.
11. Ferkol, T., Perales, J.C., Eckman, E., Kaetzel, C.S., Hanson, R.W., Davis, P.B.: Gene transfer into the airway epithelium of animals by targeting the polymeric immunogloburin receptor. J. Clin. Invest., 95: 493~502, 1995.