Targeted in vivo delivery of therapeutic gene into experimental squamous cell carcinomas using anti-epidermal growth factor receptor antibody: Immunogene approach

Human Gene Therapy

Volumn 9, Issue 18, 1998, Pages 2673-2681

  Chen, Jiabing ^a   Gamou, Shinobu ^a   Takayanagi, Atsushi ^a   Ohtake, Yuichiro ^a   Ohtsubo, Masafumi ^a   Shimizu, Nobuyoshi ^a  

^a KEIO UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

BETA GALACTOSIDASE; CHLORAMPHENICOL ACETYLTRANSFERASE; DNA; EPIDERMAL GROWTH FACTOR RECEPTOR; GANCICLOVIR; IMMUNOGLOBULIN F(AB) FRAGMENT; MESSENGER RNA; POLYLYSINE; RECEPTOR ANTIBODY; THYMIDINE KINASE;

ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; GENE TARGETING; GENE THERAPY; HERPES SIMPLEX VIRUS; HUMAN; HUMAN CELL; INTRAPERITONEAL DRUG ADMINISTRATION; KIDNEY; LIVER; NONHUMAN; NUDE MOUSE; SQUAMOUS CELL CARCINOMA; SUICIDE GENE;

FELIS CATUS; HERPES; MUS MUSCULUS; SIMPLEXVIRUS;

EID: 0032506793     PISSN: 10430342     EISSN: None     Source Type: Journal    
DOI: 10.1089/hum.1998.9.18-2673     Document Type: Article

References (29)

1. BEHZADIAN, M.A., and SHIMIZU, N. (1985). Monoclonal antibody that immunoreacts with a subclass of human receptors for epidermal growth factor. Cell Struct. Funct. 10, 219-232.
2. BI, W.L., KIM, Y.G., FELICIANO, E.S., PAVELIC, L., WILSON, K.M., PAVELIC, Z.P., and STAMBROOK, P.J. (1997). An HSV-tk-mediated local and distant antitumor bystander effect in tumors of head and neck origin in athymic mice. Cancer Gene Ther. 4, 246-252.
3. BUSCHLE, M., COTTEN, M., KIRLAPPOS, H., MECHTLER, K., SCHAFFNER, G., ZAUNER, W., BIRNSTIEL, M.L., and WAGNER, E. (1995). Receptor-mediated gene transfer into human T lymphocytes via binding of DNA/CD3 antibody particles to the CD3 T cell receptor complex. Hum. Gene Ther. 6, 753-761.
4. CHEN, J., GAMOU, S., TAKAYANAGI, A., and SHIMIZU, N. (1994). A novel gene delivery system using EGF receptor-mediated endocytosis. FEBS Lett. 338, 167-169.
5. CHEN, J., GAMOU, S., TAKAYANAGI, A., OHTAKE, Y., OHTSUBO, M., and SHIMIZU, N. (1998). Receptor-mediated gene delivery using Fab fragments of anti-epidermal growth factor receptor antibodies: Improved immunogene approach. Cancer Gene Ther. (in press).
6. COURNOYER, D., and CASKEY, C.T. (1993). Gene therapy of the immune system. Annu. Rev. Immunol. 11, 297-329.
7. CRISTIANO, R.J., and CURIEL, D.T. (1996). Strategies to accomplish gene delivery via the receptor-mediated endocytosis pathway. Cancer Gene Ther. 3, 49-57.
8. CULVER, K.W., RAM, Z., WALLBRIDGE, S., ISHII, H., OLDFIELD, E.H., and BLAESE, R.M. (1992). In vivo gene transfer with retroviral vector-producer cells for treatment of experimental brain tumors. Science 256, 1550-1552.
9. FOSTER, B.J., and KERN, J.A. (1997). HER2-targeted gene therapy. Hum. Gene Ther. 8, 719-727.
10. FUKUYAMA, R., and SHIMIZU, N. (1991). Detection of epidermal growth factor receptors and E-cadherins in the basolateral membrane of A431 cells by laser scanning fluorescence microscopy. Jpn. J. Cancer Res. 82, 8-11.
11. GAMOU, S., HUNTS, J., HARIGAI, H., HORIHASHI, S., SHIMOSATO, Y., PASTAN, I., and SHIMIZU, N. (1987). Molecular evidence for the lack of epidermal growth factor receptor gene expression in small cell lung carcinoma cells. Cancer Res. 47, 2668-2673.
12. GAMOU, S., HIRAI, M., RIKIMARU, K., ENOMOTO, S., and SHIMIZU, N. (1988). Biosynthesis of the epidermal growth factor receptor in human squamous cell carcinoma lines: Secretion of the truncated receptor is not common to epidermal growth factor receptor-hyperproducing cells. Cell Struct. Funct. 13, 25-38.
13. CODING, J.W. (1983). Production and application of monoclonal antibodies in cell biology, biochemistry and immunology. In Monoclonal Antibodies: Principles and Practice. J.W. Goding, ed. (Academic Press, New York) pp. 118-122.
14. GRASSO, A.W., and WU, G.Y. (1994). Therapeutic implications of delivery and expression of foreign genes in hepatocytes. Adv. Pharmacol. 28, 169-192.
15. HIROTA, N., UEDA, M., OZAWA, S., ABE, O., and SHIMIZU, N. (1989). Suppression of an epidermal growth factor receptor-hyperproducing tumor by an immunotoxin conjugate of gelonin and a monoclonal anti-epidermal growth factor receptor antibody. Cancer Res. 49, 7106-7109.
16. HOUSTON, L.L. (1993). Targeted delivery of toxins and enzymes by antibodies and growth factors. Curr. Opin. Biotechnol. 4, 739-744.
17. LEW, D., PARKER, S.E., LATIMER, T., ABAI, A.M., KUWAHARA-RUNDELL, A., DOH, S.G., YANG, Z.Y., LAFACE, D., GROMKOSKI, S.H., NABEL, G.J., MANTHORPE, M., and NORMAN, J. (1995). Cancer gene therapy using plasmid DNA: Pharmacokinetic study of DNA following injection in mice. Hum. Gene Ther. 6, 553-564.
18. MESNIL, M., PICCOLI, C., TIRABY, G., WILLECKE, K., and YAMASAKI, H. (1996). Bystander killing of cancer cells by herpes simplex virus thymidine kinase gene is mediated by connexins. Proc. Natl. Acad. Sci. U.S.A. 93, 1831-1835.
19. MORGAN, R.A., and ANDERSON, W.F. (1993). Human gene therapy. Annu. Rev. Biochem. 62, 191-217.
20. OSAKU, M., UEDA, M., ANDO, N., SHINOZAWA, Y., HIROTA, N., SHIMIZU, N., and ABE, O. (1991). Targeted killing of squamous carcinoma cells by a monoclonal antibody-peplomycin conjugate which recognizes the EGF receptor. Anticancer Res. 11, 1951-1956.
21. OZAWA, S., UEDA, M., ANDO, N., ABE, O., MINOSHIMA, S., and SHIMIZU, N. (1989). Selective killing of squamous carcinoma cells by an immunotoxin that recognizes the EGF receptor. Int. J. Cancer 43, 152-157.
22. SCHNIERLE, B.S., and GRONER, B. (1996). Retroviral targeted delivery. Gene Ther. 3, 1069-1073.
23. SHIMIZU, N. (1992). Epidermal growth factor receptors in lung cancer. In Lung Cancer Differentiation: Implications for Diagnosis and Treatment. S.E. Bernal and P.J. Hesketh, eds. (Marcel Dekker, New York) pp. 137-158.
24. SHIMIZU, N., KONDO, I., GAMOU, S., BEHZADIAN, M.A., and SHIMIZU, Y. (1984). Genetic analysis of hyperproduction of epidermal growth factor receptors in human epidermoid carcinoma A431 cells. Somat. Cell Mol. Genet. 10, 45-53.
25. SHIMIZU, N., CHEN, J., GAMOU, S., and TAKAYANAGI, A. (1996a). Immunogene approach toward cancer gene therapy using the epidermal growth factor receptor-mediated gene delivery. Cancer Gene Ther. 3, 113-120.
26. SHIMIZU, N., CHEN, J., TAKAYANAGI, A., and GAMOU, S. (1996b). Use of the growth factor receptor-mediated endocytosis for therapeutic gene delivery: Immunogene approach. Cell. Pharmacol. AIDS Sci. 3, 263-267.
27. TOLSTOSHEV, P. (1993). Gene therapy, concepts, current trials and future directions. Annu. Rev. Pharmacol. Toxicol. 33, 573-596.
28. WATTIAUX, R., JADOT, M., DUBOIS, F., MISQUITH, S., and WATTIAUX-DE CONINCK, S. (1995). Uptake of exogenous DNA by rat liver - effect of cationic lipids. Biochem. Biophys. Res. Commun. 213, 81-87.
29. ZABNER, J., FASBENDER, A.J., MONINGER, T., POELLINGER, K.A., and WELSH, M.J. (1995). Cellular and molecular barriers to gene transfer by a cationic lipid. J. Biol. Chem. 270, 18997-19007.