The impaired immune response to diphtheria vaccination in elderly chronic hemodialysis patients is related to zinc deficiency

Biogerontology

Volumn 1, Issue 1, 2000, Pages 61-66

  Kreft, Burkhard ^a   Fischer, Andrea ^a   Krüger, Sabine ^a   Sack, Klaus ^a   Kirchner, Holger ^a   Rink, Lothar ^a  

^a UNIVERSITY OF LÜBECK   (Germany)

Author keywords

Diphtheria; Elderly; Hemodialysis; Immunology; Vaccination; Zinc

Indexed keywords

DIPHTHERIA TOXOID; ZINC;

AGED; AGING; ARTICLE; CHRONIC DISEASE; FEMALE; HUMAN; IMMUNOLOGY; MALE; METABOLISM; RENAL REPLACEMENT THERAPY; VACCINATION;

AGED; AGING; CHRONIC DISEASE; DIPHTHERIA TOXOID; FEMALE; HUMANS; MALE; RENAL DIALYSIS; VACCINATION; ZINC;

EID: 0034570973     PISSN: 13895729     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1010077622172     Document Type: Article

References (28)

1. Birmingham DJ, Shen XP, Hartman JA, Dillon JJ and Hebert LA (1996) Effect of human recombinant erythropoietin therapy on antibody response to immunization in chronic hemodialysis patients. Kidney Int 50: 543-549
2. Bonomini M, Manfrini V, Capelli P and Albertazi A (1993) Zinc and cell-mediated immunity in chronic uremia. Nephron 65: 1-4
3. Cakman I, Rohwer J, Schütz RM, Kirchner H and Rink L (1996) Dysregulation between TH1 and TH2 T cell subpopulations in the elderly. Mech Ageing Dev 87: 197-209
4. Cakman I, Kirchner H and Rink L (1997) Zinc supplementation reconstitutes the production of interferon-α by leukocytes from elderly persons. J Interferon Cytokine Res 17: 469-472
5. Cunningham-Rundles S, Cunnibgham-Rundles C, Dupont B, Good RA (1987) Zinc induced activation of human B lymphocytes. Clin Exp Immunol 70: 440-448
6. Driessen C, Hirv K, Wellinghausen N, Kirchner H and Rink L (1995) Influence of serum on zinc, toxic shock syndrome toxin-1 and lipopolysaccharide-induced production of interferon-γ and interleukin-1β by human mononuclear cells. J Leukoc Biol 57: 904-908
7. Girndt M, Pietsch M and Köhler H (1995) Tetanus immunzation and its association to hepatitis B vaccination in patients with chronic renal failure. Am J Kidney Dis 26: 454-460
8. Grekas D, Alivanis P, Kotzadanis P, Kiriazopoulou V, Pyrpasopoulos M, Tourkantonis A and Hatzipantou P (1992) Influenza vaccination in chronic hemodialysis patients. The effect of zinc supplementation. Renal Failure 14: 575-578
9. Hübel E, Kiefer T, Weber J, Mettang T and Kuhlmann U (1991) In vivo effect of 1,25-dihydroxyvitamin D3 on phagocyte function in hemodialysis patients. Kidney Int 40: 927-933
10. James K (1990) Interactions between cytokines and α2-macroglobulin. Immunol Today 11: 163-166
11. Kimmel PL, Phillips TM, Lew SQ and Langman CB (1996) Zinc modulates mononuclear cellular calcitriol metabolism in peritoneal dialysis patients. Kidney Int 49: 1407-1412
12. Klouche M, Lühmann D and Kirchner H (1995) Low prevalence of diphtheria antitoxin in children and adults in northern Germany. Eur J Clin Microbiol Infect Dis 14: 682-685
13. Kouw PM, Konings CH, De Vries PM, Van Der Meulen J and Oe PL (1991) Effects of zinc supplementation on zinc status and immunity in haemodialysis patients. J Trace Elem Electrolytes Health Dis 5: 115-119
14. Kreft B, Klouche M, Kreft R, Kirchner H and Sack K (1997) Low efficiency of active immunization against diphtheria in chronic hemodialysis patients. Kidney Int 52: 212-216
15. Ligthart GJ, Coberand JX, Fournier C, Galanaud P, Hijmans W, Kennes B, Müller-Hermelink HK and Steinmann GG (1984) Admission criteria for immunogerontological studies in man: the senieur protocol. Mech Ageing Dev 28: 47-55
16. Mahajan SK, Bowersox EM, Rye DL, Abu-Hamdan DK, Prasad AS, McDonald FD and Biersack KL (1989) Factors underlying abnormal zinc metabolism in uremia. Kideny Int 36: 269-273
17. Maple PA, Efstratiou A, George RC, Andrews NJ and Sesardic D (1995) Diphtheria immunity in UK blood donors. Lancet 345: 963-965
18. Mortimer EA (1994) Diphtheria toxoid. In: Plotkin SA and Mortimer EA Jr (eds) Vaccines, pp 41-56. W. B. Saunders Company, Philadelphia
19. Murihead N, Kertesz A and Flanagan PR (1986) Zinc metabolism in patients on maintenance hemodialysis. Am J Nephrol 6: 422-426
20. Rawer P, Willems Wr, Breidenbach T, Guttmann W, Pabst W and Schutterle G (1987) Seroconversion rate, hepatitis B vaccination, hemodialysis, and zinc supplementation. Kidney Int 32: 149-152
21. Sachs L (1992) Angewandte Statistik. Springer-Verlag, Heidelberg
22. Sennesael JJ, van der Niepen P and Verbeelen DL (1991) Treatment with recombinant human erythropoietin increases antibody titers after hepatitis B vaccination in dialysis patients. Kidney Int 40: 121-128
23. Sokal RR and Rohlf FJ (1969) Biometry. The Principles and Practice of Statistics in Biological Research. Freedman and Company, San Francisco
24. Taylor AW and Mortensen RF (1991) Effect of α2-macroglobulin on cytokine mediated human C-reactive protein production. Inflammation 15: 61-70
25. Wellinghausen N and Rink L (1998) The significance of zinc for leukocyte biology. J Leukoc Biol 64: 571-577
26. Wellinghausen N, Fischer A, Kirchner H and Rink L (1996) Interaction of zinc with human peripheral blood mononuclear cells. Cell Immunol 171: 255-261
27. Wellinghausen N, Kirchner H and Rink L (1997) The immunobiology of zinc. Immunol Today 18: 519-521
28. World Health Organization (1994) Expanded programme on immunization. Diphtheria epidemic.Weekly Epidemiol Rec 69: 253-260