메뉴 건너뛰기




Volumn 23, Issue 6, 2000, Pages 554-558

Modulation of NAD (P) H:Quinone Oxidoreductase (NQO1) Activity Mediated by 5-Arylamino-2-methyl-4,7-dioxobenzothiazoles and their Cytotoxic Potential

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; DRUG DERIVATIVE; ECHINOMYCIN; ENZYME INHIBITOR; QUINOMYCIN; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE (PHOSPHATE) DEHYDROGENASE (QUINONE); THIAZOLE DERIVATIVE;

EID: 0034567175     PISSN: 02536269     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF02975239     Document Type: Article
Times cited : (10)

References (13)
  • 1
    • 0029969531 scopus 로고    scopus 로고
    • Role of NAD(P)H: Quinone oxidoreductase (DT-diaphorase) in cytotoxicity and induction of DNA damage by streptonigrin
    • Beall, H. D., Liu, Y., Siegel, D., Bolton, E. M., Gilson, N. W. and Ross, D., Role of NAD(P)H: quinone oxidoreductase (DT-diaphorase) in cytotoxicity and induction of DNA damage by streptonigrin. Biochem. Pharmacol., 51, 645-652 (1996).
    • (1996) Biochem. Pharmacol. , vol.51 , pp. 645-652
    • Beall, H.D.1    Liu, Y.2    Siegel, D.3    Bolton, E.M.4    Gilson, N.W.5    Ross, D.6
  • 2
    • 0029121481 scopus 로고
    • Nicotinamide adenine dinucleotide (Phosphate): Quinone oxidoreductase (DT-diaphorase) as a target for bioreductive antitumor quinones: quinone cytotoxicity and selectivity in human lung and breast cancer cell lines
    • Beall, H. D., Murphy, A. M., Siegel, D., Hargreaves, R. H. J., Butler, J. and Ross, D., Nicotinamide adenine dinucleotide (Phosphate): Quinone oxidoreductase (DT-diaphorase) as a target for bioreductive antitumor quinones: quinone cytotoxicity and selectivity in human lung and breast cancer cell lines. Mol. Pharmacol., 48, 499-504 (1995).
    • (1995) Mol. Pharmacol. , vol.48 , pp. 499-504
    • Beall, H.D.1    Murphy, A.M.2    Siegel, D.3    Hargreaves, R.H.J.4    Butler, J.5    Ross, D.6
  • 3
    • 0017184389 scopus 로고
    • A rapid and sensitive method for the quantitation of microgram quantities of protein using the principle of protein-dye binding
    • Bradford, M. M., A rapid and sensitive method for the quantitation of microgram quantities of protein using the principle of protein-dye binding. Anal. Biochem., 72, 248-254 (1976).
    • (1976) Anal. Biochem. , vol.72 , pp. 248-254
    • Bradford, M.M.1
  • 4
    • 77957000392 scopus 로고
    • DT-diaphorase
    • Ernster, L., DT-diaphorase. Methods Enzymol., 10, 309-317 (1967).
    • (1967) Methods Enzymol. , vol.10 , pp. 309-317
    • Ernster, L.1
  • 5
    • 0033517085 scopus 로고    scopus 로고
    • Novel quinolinequinone antitumor agents: Structure-metabolism studies with NAD(P)H: quinone oxidoreductase (NQO1)
    • Fryatt, T., Goroski, D. T., Nilson, Z. D., Moody, C. J. and Beall, H. D., Novel quinolinequinone antitumor agents: structure-metabolism studies with NAD(P)H: quinone oxidoreductase (NQO1). Bioorg. Med. Chem. Lett., 9 (15), 2195-2198 (1999).
    • (1999) Bioorg. Med. Chem. Lett. , vol.9 , Issue.15 , pp. 2195-2198
    • Fryatt, T.1    Goroski, D.T.2    Nilson, Z.D.3    Moody, C.J.4    Beall, H.D.5
  • 6
    • 0032476106 scopus 로고    scopus 로고
    • Cytostatic mechanism and antitumor potential of novel 1H-cyclopenta[b]benzofuran lignans isolated from Aglaia elliptica
    • Lee, S. K., Cui, B., Metha, R. R., Kinghorn, A. D. and Pezzuto, J. M., Cytostatic mechanism and antitumor potential of novel 1H-cyclopenta[b]benzofuran lignans isolated from Aglaia elliptica. Chem.-Biol. Interact., 115, 215-228 (1998).
    • (1998) Chem.-Biol. Interact. , vol.115 , pp. 215-228
    • Lee, S.K.1    Cui, B.2    Metha, R.R.3    Kinghorn, A.D.4    Pezzuto, J.M.5
  • 7
    • 0033566314 scopus 로고    scopus 로고
    • Inhibition of DT-diaphorase [NAD(P)H: Quinone oxidoreductase, EC 1.6.99.2] by 5,6-dimethylxanthenone-4-acetic acid (DMXAA) and flavone-8-acetic acid (FAA): implications for bioreductive drug development
    • Phillips, R. M., Inhibition of DT-diaphorase [NAD(P)H: quinone oxidoreductase, EC 1.6.99.2] by 5,6-dimethylxanthenone-4-acetic acid (DMXAA) and flavone-8-acetic acid (FAA): implications for bioreductive drug development. Biochem. Pharmacol., 58, 303-310 (1999).
    • (1999) Biochem. Pharmacol. , vol.58 , pp. 303-310
    • Phillips, R.M.1
  • 8
    • 0025860979 scopus 로고
    • Streptonigrin and related compounds 5. Synthesis and evaluation of some isoquinolin analogues
    • Rao, K. V. and Beach, J. W., Streptonigrin and related compounds 5. Synthesis and evaluation of some isoquinolin analogues. J. Med. Chem., 34, 1871-1879 (1991).
    • (1991) J. Med. Chem. , vol.34 , pp. 1871-1879
    • Rao, K.V.1    Beach, J.W.2
  • 9
    • 0029952342 scopus 로고    scopus 로고
    • Streptonigrin and related compounds. 6. Synthesis and activity of some quinoxaline analogues
    • Rao, K. V. and Rock, C. P., Streptonigrin and related compounds. 6. Synthesis and activity of some quinoxaline analogues. J. Heterocycl. Chem., 33, 447-458 (1996).
    • (1996) J. Heterocycl. Chem. , vol.33 , pp. 447-458
    • Rao, K.V.1    Rock, C.P.2
  • 10
    • 0033583537 scopus 로고    scopus 로고
    • Synthesis and cytotoxic activities of 6-chloro-7-arylamino-5,8-isoquinolinediones
    • Ryu, C. K., Lee, I. K., Jung, S. H. and Lee, C. O., Synthesis and cytotoxic activities of 6-chloro-7-arylamino-5,8-isoquinolinediones. Bioorg. Med. Chem. Lett., 9(8), 1075-1080 (1999).
    • (1999) Bioorg. Med. Chem. Lett. , vol.9 , Issue.8 , pp. 1075-1080
    • Ryu, C.K.1    Lee, I.K.2    Jung, S.H.3    Lee, C.O.4
  • 11
    • 0034611440 scopus 로고    scopus 로고
    • 5-Arylamino-2-methyl-4,7-dioxobenzothiazoles as inhibitors of cyclindependent kinase 4 and cyctotoxic agents
    • Ryu, C. K., Lee, Kang, H. Y., Lee, S. K., Nam, K. A., Hong, C. Y., Ko, W. G. and Lee, B. H., 5-Arylamino-2-methyl-4,7-dioxobenzothiazoles as inhibitors of cyclindependent kinase 4 and cyctotoxic agents. Bioorg. Med. Chem. Lett., 10(5), 461-464 (2000)
    • (2000) Bioorg. Med. Chem. Lett. , vol.10 , Issue.5 , pp. 461-464
    • Ryu, C.K.1    Lee2    Kang, H.Y.3    Lee, S.K.4    Nam, K.A.5    Hong, C.Y.6    Ko, W.G.7    Lee, B.H.8
  • 12
    • 0022530901 scopus 로고
    • Structure-activity relationship among simple bicyclic analogues. Rate dependent of DNA degradation on quinone reduction potential
    • Shaikh, I. A., Johnson, F. and Grollman, A. P., Structure-activity relationship among simple bicyclic analogues. Rate dependent of DNA degradation on quinone reduction potential. J. Med. Chem., 29, 1329-1340 (1986).
    • (1986) J. Med. Chem. , vol.29 , pp. 1329-1340
    • Shaikh, I.A.1    Johnson, F.2    Grollman, A.P.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.