Hypoglycemia: Pathophysiology and treatment

Endocrinology and Metabolism Clinics of North America

Volumn 29, Issue 4, 2000, Pages 725-743

  Herbel, G ^a   Boyle, P J ^a  

^a UNIVERSITY OF NEW MEXICO HEALTH SCIENCES CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIHYPERTENSIVE AGENT; DIAZOXIDE; GLUCOSE; INSULIN; ORAL ANTIDIABETIC AGENT; SULFONYLUREA DERIVATIVE;

GLUCOSE BRAIN LEVEL; HUMAN; HUMAN CELL; HUMAN TISSUE; HYPOGLYCEMIA; INSULIN INFUSION; INSULIN RELEASE; NON INSULIN DEPENDENT DIABETES MELLITUS; PATHOPHYSIOLOGY; PREDICTION; PRIORITY JOURNAL; REVIEW;

EID: 0034544650     PISSN: 08898529     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0889-8529(05)70161-4     Document Type: Article

References (104)

1. Veterans Affairs Cooperative Study on glycemic control and complications in type II diabetes (VA CSDM): Results of the feasibility trial. Veterans Affairs Cooperative Study in Type II Diabetes
2. Hypoglycemia in childhood diabetes. II. Effect of subcutaneous or intramuscular injection of different doses of glucagon
3. Ketone infusion lowers hormonal responses to hypoglycemia: Evidence for acute cerebral utilization of a non-glucose fuel
4. Defective glucose counterregulation after strict glycemic control of insulin-dependent diabetes mellitus
5. Effect of intensive insulin therapy on glycemic thresholds for counterregulatory hormone release
6. Rate of glucose fall does not affect counterregulatory hormone responses to hypoglycemia in normal and diabetic humans
7. The Physicians' Desk Reference, ed 52
8. Incidence of nocturnal hypoglycemia in insulin-dependent diabetic patients on intensive therapy
9. Role of brain in counterregulation on insulin-induced hypoglycemia in dogs
10. Glucose deprivation causes post-translational enhancement of brain capillary endothelial glucose transporter gene expression via GLUT1 mRNA stabilization
11. Role of hepatic autoregulation in defense against hypoglycemia in humans
12. Abnormal glucose counterregulation after subcutaneous insulin in insulin-dependent diabetes mellitus
13. Glucose counterregulation during prolonged hypoglycemia in normal humans
14. Local ventromedial hypothalamus glucose perfusion blocks counterregulation during systemic hypoglycemia in awake rats
15. Ventromedial hypothalamus lesions in rats suppress counterregulatory hormone responses to hypoglycemia
16. Local ventromedial hypothalamus glycopenia triggers counterregulatory hormone release
17. Cushing's disease, glucocorticoid excess, glucocorticoid deficiency and diabetes
18. Growth hormone, cortisol, or both are involved in defense against, but are not critical to recovery from hypoglycemia
19. Octreotide reverses hyperinsulinemia and hypoglycemia induced by oral sulfonylurea overdose
20. Brain glucose uptake and unawareness of hypoglycemia in patients with insulin dependent diabetes mellitus
21. Adaptation in brain glucose uptake following recurrent hypoglycemia
22. Plasma glucose concentrations at the onset of hypoglycemic symptoms in patients with poorly controlled diabetes and in nondiabetics
23. Absence of the dawn phenomenon and abnormal lipolysis in patients with type I diabetes and chronic growth hormone deficiency
24. A prospective trial of risk factors for sulphonylurea-induced hypoglycemia in type 2 diabetes mellitus
25. Starvation in man
26. Insulin regulation of renal glucose metabolism in humans
27. Renal glucose production during insulin-induced hypoglycemia in humans
28. The role of insulin and glucagon in the regulation of basal glucose production in the postabsorptive state
29. Circulation and energy metabolism of the brain
30. Regulation of glucose metabolism by sympathochromaffin cathecholamines
31. In the absence of conterregulatory hormones, the increase in hepatic glucose production during insulin-induced hypoglycemia in dogs is initiated in the liver rather than in the brain
32. Restoration of hypoglycemia unawareness in patients with long duration insulin-dependent diabetes mellitus
33. Glucose counterregulation in man
34. Hypoglycemia: Pathophysiology, Diagnosis and Treatment
35. Iatrogenic hypoglycemia as a cause of hypoglycemia associated autonomic failure in IDDM: A vicious cycle
36. Hypoglycemia-associated autonomic failure in insulin-dependent diabetes mellitus
37. Reversal of hypoglycemia unawareness, but not defective glucose counterregulation, in IDDM
38. Comparison of glucose counterregulation during short-term and prolonged hypoglycemia in normal humans
39. Contribution of adrenergic mechanisms to glucose counterregulation in humans
40. Demonstration of a role for growth hormone in glucose counterregulation
41. Epidemiology of severe hypoglycemia in the DCCT
42. The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus
43. Importance of hepatic glucoreceptors in sympathoadrenal response to hypoglycemia
44. Primacy of liver glucosensors in the sympathetic response to progressive hypoglycemia
45. Glycogen in astrocytes: Possible function as lactate supply for neighboring cells
46. Long-term recovery from unawareness, deficient counterregulation, and lack of cognitive dysfunction during hypoglycemia following institution of rational intensive therapy in IDDM
47. Meticulous prevention of hypoglycemia normalizes the glycemic thresholds and magnitude of most of neuroendocrine responses to, symptoms of, and cognitive function during hypoglycemia in intensively treated patients with short-term IDDM
48. Hypoglycemia in hospitalized patients
49. The role of adrenaline in hypoglycaemic reactions in man
50. Spontaneous hypoglycemia associated with chronic renal failure
51. Counterregulation during hypoglycemia is directed by widespread brain regions
52. Central nervous system-mediated stimulation of glucagon secretion in the dog following 2-deoxy-glucose
53. Hypoglycemia in compensated chronic renal insufficiency
54. The role of adrenergic mechanisms in the substrate and hormonal response to insulin induced hypoglycemia in man
55. Hormonal mechanisms of recovery from insulin-induced hypoglycemia in man
56. Hypoglycemia unawareness
57. Hormonal mechanisms in acute glucose counterregulation: The relative roles of glucagon, epinephrine, norepinephrine, growth hormone and cortisol
58. Oral hypoglycemic agents
59. The role of liver glucosensors in the integrated sympathetic response induced by deep hypoglycemia in dogs
60. Cerebral blood flow and substrate utilization in insulin treated diabetic subjects
61. 11C] glucose uptake and metabolism in the brain of insulin-dependent diabetic subjects
62. A treatable cause for recurrent severe hypoglycaemia
63. Reduced neuroendocrine and symptomatic response to subsequent hypoglycemia after one episode of hypoglycemia in nondiabetic humans
64. Novel glucosensor for hypoglycemic detection localized to the portal vein
65. Higher glycemic thresholds for symptoms during β-adrenergic blockade in IDDM
66. Type I diabetes and insulin therapy
67. Intensive insulin therapy for treatment of type I diabetes
68. Insulin and glucagon in prevention of hypoglycemia during exercise in humans
69. Nutrition principles and diabetes: A role for "lente carbohydrate?"
70. Alcohol causes hypoglycaemic unawareness in healthy volunteers and patients with type 1 (insulin-dependent) diabetes
71. Glucose transporter gene expression in rat brain: Pretranslational changes associated with chronic insulin-induced hypoglycemia, fasting and diabetes
72. Octreotide: A long-acting inhibitor of endogenous hormone secretion for human metabolic investigations
73. Upregulation of blood-brain barrier GLUTI glucose transporter protein and mRNA in experimental chronic hypoglycemia
74. Contributions of gluconeogenesis and glycogenolysis during glucose counterregulation in normal humans
75. Postexercise late-onset hypoglycemia in insulin-dependent diabetic patients
76. Protection by lactate of cerebral function during hypoglycaemia
77. Catecholamines in prevention of hypoglycemia during exercise in humans
78. Decreased number of glucose transporters at blood-brain barrier
79. Chronic hypoglycemia increases brain glucose transport
80. Metabolic fuel and amino acid transport into the brain in experimental diabetes mellitus
81. Reversibility of hypoglycemia unawareness
82. Hierarchy of glycemic thresholds for counterregulatory hormone secretion, symptoms, and cerebral dysfunction
83. Intensive insulin therapy prevents the progression of diabetic microvascular complications in Japanese patients with non insulin-dependent diabetes mellitus. A randomized prospective 6-year study
84. Brain metabolism during fasting
85. Brain metabolism: A perspective from the blood-brain barrier
86. Brain-type glucose transporter (GLUT-I) is selectively localized to the blood-brain barrier: Studies with quantitative Western blotting and in situ hybridization
87. Management of chloropropamide induced hypoglycemia with diazoxide
88. Unaltered cerebral blood flow during hypoglycemic activation of the sympathochromaffin system in human subjects
89. The effect of long-term intensified insulin treatment on the development of microvascular complications of diabetes mellitus
90. Role of glucagon, catecholamines and growth hormone in human glucose counterregulations
91. Epinephrine, norepinephrine, glucagon, and growth hormone release in association with physiological decrements in the plasma glucose concentration in normal and diabetic man
92. Glycemic thresholds for activation of glucose counterregulatory systems are higher than the thresholds for symptoms
93. Insulinoma: Clinical and diagnostic features of 60 consecutive cases
94. Reciprocal influence of the ventromedial and lateral hypothalamic nuclei on blood glucose level and liver glycogen content
95. Individual sulfonylureas and serious hypoglycemia in older people
96. The vascular order of islet cellular perfusion in the human pancreas
97. Autonomic mediation of glucagon secretion during hypoglycemia: Implications for impaired alpha-cell responses in type I diabetes
98. Hexose uptake in primary cultures of bovine microvessel endothelial cells. I. Basic characteristics and effects of D-glucose and insulin
99. Mechanism of awareness of hypoglycemia: Perception of neurogenic (predominantly cholinergic) rather than neuroglycopenic symptoms
100. Metabolic coupling between glia and neurons
101. Chronic insulin hypoglycemia induces GLUT-3 protein in rat brain neurons
102. Intensive blood glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes (UKPDS 33)
103. Glucose transporter proteins in brain: Delivery of glucose to neurons and glia
104. Effect of hyperketonemia and hyperlacticacidemia on symptoms, cognitive dysfunction and counterregulatory hormone responses during hypoglycemia in normal humans