A precise and user-independent quantification technique for regional comparison of single volume proton MR spectroscopy of the human brain

NMR in Biomedicine

Volumn 13, Issue 7, 2000, Pages 398-406

  Helms, Gunther ^a,b  

^a KAROLINSKA INSTITUTE   (Sweden)

^b KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

Author keywords

Absolute quantification; Human brain; Proton spectroscopy; Regional comparison; RF inhomogeneity

Indexed keywords

CHOLINE; CREATINE; N ACETYLASPARTIC ACID; WATER;

ADULT; ARTICLE; BRAIN; CEREBROSPINAL FLUID; CONCENTRATION (PARAMETERS); DECOMPOSITION; FEMALE; HUMAN; HUMAN EXPERIMENT; INSULA; MALE; METABOLITE; NORMAL HUMAN; PARIETAL LOBE; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE; QUANTITATIVE ASSAY; SIGNAL PROCESSING; SPECTROSCOPY; TECHNIQUE; WATER CONTENT; WHITE MATTER;

BODY WATER; BRAIN; HUMANS; MAGNETIC RESONANCE SPECTROSCOPY; MODELS, THEORETICAL; PHANTOMS, IMAGING; PROTONS; QUALITY CONTROL;

EID: 0034537605     PISSN: 09523480     EISSN: None     Source Type: Journal    
DOI: 10.1002/1099-1492(200011)13:7<398::AID-NBM660>3.0.CO;2-W     Document Type: Article

References (17)

1. The signal-to-noise-ratio of the nuclear magnetic resonance experiment
2. Elimination of signal strength dependence upon coil-loading - An aid to metabolite quantitation when the sample volume changes
3. Direct absolute quantification of metabolites in the human brain with in vivo localized proton spectroscopy
4. Absolute quantification of water and metabolites in the human brain. I. Compartments and water
5. Absolute quantification of water and metabolites in the human brain. II. Metabolite concentrations
6. Absolute concentrations of metabolites in the adult human brain in vivo: Quantification of localized proton MR spectra
7. Absolute quantitative proton NMR spectroscopy based on the amplitude of the local water suppression pulse. Quantification of brain water and metabolites
8. Three methods of calibration in quantitative proton MR spectroscopy
9. Localized proton spectroscopy using stimulated echoes
10. Automated single-voxel proton MRS: Technical development and multisite verification
11. In vivo proton spectroscopy in the presence of eddy currents
12. Estimation of metabolite concentrations from localized in vivo proton NMR spectra
13. Analysis of 1.5 Tesla proton MR spectra of human brain using LCModel and an imported basis set
14. Regional metabolite concentrations in human brain as determined by quantitative localized proton MRS
15. Quantitative spectroscopic imaging of the human brain
16. Relative concentrations of proton MR visible neurochemicals in gray and white matter in human brain
17. Calibration of the radio frequency field for magnetic resonance imaging