No consistent pattern of mutations in p53 and ras genes in liver tumors of rat treated with the drinking water mutagen 3-chloro-4-(dichloromethyl)-5-hydroxy-2(5h)-furanone (MX)

Environmental and Molecular Mutagenesis

Volumn 36, Issue 4, 2000, Pages 292-300

  Komulainen, Hannu ^a   Hakulinen, Pasi ^a   Servomaa, Kristina ^b   Makkonen, Kaisa ^c   Vasara, Ritva ^b   Mäki Paakkanen, Jorma ^a   Kosma, Veli Matti ^d  

^a NATIONAL PUBLIC HEALTH INSTITUTE   (Finland)

^b Finland's Environmental Administration   (Finland)

^c Department of Research Radiation and Nuclear Safety Authority ^*  (Finland)

^d KUOPIO UNIVERSITY HOSPITAL   (Finland)

Author keywords

Carcinogenicity; Chlorination; Drinking water; Furanone; MX; P53; Ras; Rat

Indexed keywords

3 CHLORO 4 DICHLOROMETHYL 5 HYDROXY 2(5H) FURANONE; CHLORINE; CYCLINE; DRINKING WATER; FURANONE DERIVATIVE; MUTAGENIC AGENT; PROTEIN P53; RAS PROTEIN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BILE DUCT CARCINOMA; BILE DUCT TUMOR; CONTROLLED STUDY; FEMALE; GEL ELECTROPHORESIS; GENE MUTATION; GENE OVEREXPRESSION; GENE SEQUENCE; IMMUNOHISTOCHEMISTRY; LIVER CARCINOGENESIS; LIVER CELL CARCINOMA; LIVER TUMOR; MALE; NONHUMAN; NUCLEIC ACID BASE SUBSTITUTION; ONCOGENE RAS; POINT MUTATION; POLYMERASE CHAIN REACTION; PROTEIN EXPRESSION; RAT; SINGLE STRAND CONFORMATION POLYMORPHISM; TUMOR SUPPRESSOR GENE;

ANIMALS; BASE SEQUENCE; DNA PRIMERS; FEMALE; FURANS; GENES, P53; GENES, RAS; IMMUNOHISTOCHEMISTRY; LIVER NEOPLASMS, EXPERIMENTAL; MALE; MUTAGENS; MUTATION; POLYMERASE CHAIN REACTION; POLYMORPHISM, SINGLE-STRANDED CONFORMATIONAL; PROLIFERATING CELL NUCLEAR ANTIGEN; RATS; RATS, WISTAR; WATER SUPPLY;

ANIMALIA; RATTUS NORVEGICUS;

EID: 0034534986     PISSN: 08936692     EISSN: None     Source Type: Journal    
DOI: 10.1002/1098-2280(2000)36:4<292::AID-EM5>3.0.CO;2-3     Document Type: Article

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