Cytokines and immuno-endocrine factors in recurrent miscarriage

Human Reproduction Update

Volumn 2, Issue 6, 1996, Pages 469-481

  Lim, K J H ^a   Odukoya, O A ^a   Li, T C ^a   Cooke, I D ^a  

^a JESSOP HOSPITAL FOR WOMEN   (United Kingdom)

Author keywords

Cytokines; Recurrent miscarriage

Indexed keywords

CYTOKINE; GAMMA INTERFERON; INTERLEUKIN 1; INTERLEUKIN 6; LUTEINIZING HORMONE; LYMPHOTOXIN; PHOSPHOLIPID ANTIBODY; TRANSFORMING GROWTH FACTOR BETA; TUMOR NECROSIS FACTOR ALPHA;

ALLOIMMUNITY; AUTOIMMUNITY; ENDOCRINE DISEASE; ENDOMETRIUM; FEMALE; HELPER CELL; HUMAN; IDIOPATHIC DISEASE; IMMUNOPATHOLOGY; PRIORITY JOURNAL; RECURRENT ABORTION; REVIEW; SPONTANEOUS ABORTION;

ABORTION, HABITUAL; CYTOKINES; ENDOCRINE GLANDS; ENDOMETRIUM; FEMALE; HUMANS; HYPOTHALAMO-HYPOPHYSEAL SYSTEM; IMMUNE SYSTEM; MODELS, BIOLOGICAL; OVARY; PREGNANCY;

EID: 0030431415     PISSN: 13554786     EISSN: None     Source Type: Journal    
DOI: 10.1093/humupd/2.6.469     Document Type: Review

References (152)

1. Adashi, E.Y. and Resnick, C.E. (1986) Antagonistic interactions of transforming growth factors in the regulation of granulosa cell differentiation. Endocrinology, 119, 1879-1881.
2. Adashi, E.Y. (1990) The potential relevance of cytokines to ovarian physiology: the emerging role of resident ovarian cells of the white blood cell series. Endocr. Rev., 11, 454-464.
3. Alberman, E. (1988) The epidemiology of repeated abortion. In Early Pregnancy Loss: Mechanisms and Treatment. Springer Verlag, New York, pp. 9-17.
4. Andreani, C.L., Payne, D.W., Packman, J.N. et al. (1991) Cytokine mediated regulation of ovarian function. J. Biol. Chem., 266, 6761-6766.
5. Ashkenazi, J., Farhi, J., Orvieto, R. et al. (1995) Polycystic ovary syndrome patients as oocyte donors: the effect of ovarian stimulation protocol on the implantation rate of the recipient. Fertil. Steril., 64, 564-567.
6. Balasch, J., Coll, O., Martorell, J. et al. (1989) Further data against HLA sharing in couples with recurrent spontaneous abortion. Gynecol. Endocrinol., 3, 63-69.
7. Bateman, A., Singh, A., Kral, T. and Solomon, S. (1989) The immune hypothalamic-pituitary-adrenal axis. Endocr. Rev., 10, 92-112.
8. Bazan, J.F. (1991) Neuropoietic cytokines in the hematopoietic fold. Neuron, 7, 197-208.
9. Bendell, J.J. and Dorrington, J. (1988) Rat thecal/interstitial cells secrete a transforming growth factor beta-like factor that promotes growth and differentiation in rat granulosa cells. Endocrinology, 123, 941-948.
10. Bonney, R.C., Watson, H., Beesley, J.S. et al. (1992) Endometrial phospholipases A2, polycystic ovaries and pelvic pain. Br. J. Obstet. Gynaecol., 99, 486-4891.
11. Bowcock, A.M., Kidd, J.R., Lathrop, M. et al. (1988) The human 'interferon-beta 2/hepatocyte stimulating factor/interleukin-6' gene: DNA polymorphism studies and localization to chromosome 7p21. Genomics, 3, 8-16.
12. Branch, D.W., Andres, R., Digre, K.B. et al. (1990a) The association of antiphospholipid antibodies with severe pre-eclampsia. Obstet. Gynecol., 73, 541-545.
13. Branch D.W., Dudley D.J., Mitchell M.D. et al. (1990b) IgG fractions from patients with antiphospholipid antibodies cause fetal death in Balb/c mice: a model for autoimmune fetal loss. Am. J. Obstet. Gynecol., 163, 210-216.
14. Branch, D.W., Silver, R.M., Blackwell, J.L. et al. (1992) Outcome of treated pregnancies in women with antiphospholipid syndrome: an update of the Utah experience. Obstet. Gynecol., 80, 614-620.
15. Brannstrom, M., Norman, R.J., Seamark, R.F. and Robertson, S.A. (1994) Rat ovary produces cytokines during ovulation. Biol. Reprod., 50, 88-94.
16. Camussi, G., Albano, E., Tetta, C. and Bussolino, F. (1991) The molecular action of tumour necrosis factor alpha. Eur. J. Biochem., 202, 3-14.
17. Casscells, W., Bazoberry, F., Speir, E. et al. (1990) Transforming growth factor β1 in normal heart and in myocardial infarction. Ann. N.Y. Acad. Sci., 593, 148-160.
18. Chaouat, G., Menu, E., Assal-Meliani, A. et al. (1994) Allopregnancy is a TH 2 like phenomenon: IL 10 can prevent CBAxDBA/2 fetal wastage and TH2 cytokine can be induced in vivo by tau interferons. Colloque Foundation Marcel Merieux, Annecy, 1994.
19. Clark, D.A., Chaput, A. and Tutton, O. (1986) Active suppression of host versus graft reaction in pregnant mice: spontaneous abortion of allogenic CBA/J, DBA/2 foetuses in the uterus of DBA/J mice correlates with deficient non T cell suppressor cell activity. J. Immunol., 136, 1668-1675.
20. Clifford, K., Rai, R., Watson, H. and Regan, L. (1994) An informative protocol for investigation of recurrent miscarriage: preliminary experience of 500 consecutive cases. Hum. Reprod., 9, 1328-1332.
21. Collette, A.A., Wakefield, L.M., Howell, F.V. et al. (1991) The growth inhibition of human breast cancer cells by a novel synthetic progestin involves the induction of transforming growth factor beta. J. Clin. Invest., 87, 277-283.
22. Coulam, C.B. (1986) Unexplained recurrent pregnancy loss: epilogue. Clin. Obstet. Gynecol., 29, 999-1004.
23. Coulam, C.B. (1992) Immunologic tests in the evaluation of reproductive disorders: a critical review. Am. J. Obstet. Gynecol., 167, 1844-1851.
24. Coulam, C.B. and Stern, J.J. (1994) Endocrine factors associated with recurrent spontaneous abortion. Clin. Obstet. Gynaecol., 37, 730-744.
25. Crosignani, P.G. (1988) The defective luteal phase. Hum. Reprod., 3, 157-160.
26. Daya, S., Clark, D.A., Devlin, C. and Jarrell, J. (1985) Preliminary characterisation of two types of suppressor cells in the human uterus. Fertil. Steril., 44, 778-785.
27. Devos, R., Cheroutre, H., Taya, Y. et al. (1982) Molecular cloning of human immune interferon cDNA and its expression in eukaryotic cells. Nucleic Acids Res., 10, 2487-2501.
28. Dinarello, C.A. (1986) Multiple biological properties of recombinant human interleukin 1 (beta). Immunobiology, 172, 301-315.
29. Dinarello, C.A. (1991) Interleukin-1 and interleukin-1 antagonism. Blood, 77, 1627-1652.
30. Dorrington, J., Chuma, A.V. and Bendell, J.J. (1988) Transforming growth factor beta and follicle stimulating hormone promote rat granulosa cell proliferation. Endocrinology, 123, 353-359.
31. Dower, S.K. and Urdal, D.L. (1987) The interleukin 1 receptor. Immunol. Today, 8, 46-51.
32. Eades, D.K., Corneium, P. and Pekala, P.H. (1988) Characterization of tumour necrosis factor receptor in human placenta. Placenta, 9, 247-251.
33. Edwards, C.K., Lorence, R.M., Dunham, D.M. et al. (1991) Hypophysectomy inhibits the synthesis of TNF alpha by rat macrophages: partial restoration by exogenous GH of IFN gamma. Endocrinology, 128, 989-996.
34. Feinman, M.A., Kliman, J.H. and Main, E.K. (1987) HLA antigen expression and induction by gamma interferon in cultured human trophoblast. Am. J. Obstet. Gynecol., 157, 1429-1434.
35. Fox, H.S., Bond, B.L. and Parslow, T.G. (1991) Estrogen regulates the IFN gamma promoter. J. Immunol., 146, 4362-4367.
36. Gajewski, T.F. and Fitch, F.W. (1988) Anti-proliferative effect of IFN-gamma in immune regulation: IFN-gamma inhibits the proliferation of Th2 but not Th1 murine helper T lymphocyte clones. J. Immunol, 140, 4245-4252.
37. Gatenby, P.A. (1989) Systemic lupus erythematosus and pregnancy. Aust. N.Z. J. Med., 19, 261-278.
38. Gibbs, V.C., Williams, S.R., Gray, P.W. et al. (1991) The extracellular domain of the human interferon gamma receptor interacts with a species-specific signal transducer. Mol. Cell. Biol., 11, 5860-5866.
39. Glinoer, D., Soto, M.F., Bourdoux, P. et al. (1991) Pregnancy in patients with mild thyroid abnormalities: maternal and neonatal repercussions. J. Clin. Endocrinol Metab., 73, 421-427.
40. Gorospe, W.C., Hughes, F.M. Jr and Spangelo, B.L. (1992) Interleukin 6: effects on and production by rat granulosa cells in vitro. Endocrinology, 130, 1750-1752.
41. Gray, P.W. and Goeddel, D.V. (1982) Structure of the human immune interferon gene. Nature, 298, 859-863.
42. Hatasaka, H.H. (1994) Recurrent miscarriage: epidemiologic factors, definitions and incidence. Clin. Obstet. Gynaecol., 37, 625-634.
43. Hibi, M., Murakami, M., Saito, M. et al. (1990) Molecular cloning and expression of an IL-6 signal transducer, gp130. Cell, 63, 1149-1157.
44. Hill, J.A. (1989) Macrophage phagocytic function in normal pregnancy and spontaneous abortion. Abstract in Proceedings of the 36th annual meeting of the Society for Gynecologic Investigation, San Diego, California, March, 1989.
45. Hill, J.A. and Anderson, D.J. (1988) Cell mediated immune mechanisms in recurrent spontaneous abortion. In Talwar, G.P. (ed.), Contraceptive Research for Today and the Nineties. Vol. 11. Springer Verlag, New York, USA pp. 171-80.
46. Hill, J.A. and Anderson, D.J. (1990) Evidence for the existence and significance of immune cells and their soluble products in reproductive tissues. Immunol. Allergy. Clin. N. Am., 10, 1-12.
47. Hill, J.A., Polgar, K., Harlow, B.L. and Anderson, D.J. (1992) Evidence of embryo and trophoblast-toxic cellular immune responses in women with recurrent spontaneous abortion. Am. J. Obstet. Gynecol., 166, 1044-1052.
48. Hill, J.A., Polgar, K. and Anderson, D.J. (1995) T helper 1 type immunity to trophoblast in women with recurrent spontaneous abortion. J. Am. Med. Assoc., 273, 1933-1936.
49. Hirano, T., Yasukawa, K., Harada, H. et al. (1986) Complementary DNA for a novel human interleukin (BSF-2) that induces B lymphocytes to produce immunoglobulin. Nature, 324, 73-76.
50. Hunt, J.S., Atherton, R.A. and Pace, J.L. (1990) Differential responses of rat trophoblast cells and embryonic fibroblasts to cytokines that regulate proliferation and class I MHC antigen expression. J. Immunol., 145, 184-189.
51. Hunt, J.S., Chen, H.L., Hu, X.L. and Tabibzadeh, S.S. (1992) Tumour necrosis factor alpha mRNA and protein in human endometrium. Hum. Reprod., 7, 141-147.
52. Hurwitz, A., Payne, D.W., Packman, J.N. et al. (1991) Cytokine mediated regulation of ovarian function: IL1 inhibits gonadotrophin induced androgen biosynthesis. Endocrinology, 129, 1250-1256.
53. Imura, H., Fukata, J. and Mori, T. (1991) Cytokines and endocrine function: interaction between the immune and neuroendocrine systems. Clin. Endocrinol., 25, 107-115.
54. Jaattela, M., Kuusela, P. and Saksela, E. (1988) Demonstration of tumour necrosis factor in human amniotic fluids and supernatants of placental and decidual tissues. Lab. Invest., 58, 48-52.
55. Jacobs, A.L., Sehgal, P.B., Julian, J. and Carson, D.D. (1992) Secretion and hormonal regulation of interleukin 6 production by mouse uterine stromal and polarised epithelial cells cultured in vitro. Endocrinology, 131, 1037-1046.
56. Jacobs, H.S. (1991) The LH hypothesis. In Shaw R.W. (ed.), Polycystic Ovaries: a Disorder or a Symptom? Parthenon Press, Carnforth, UK, pp. 91.
57. Kalra, P.S., Sahu, A. and Kalra, S.P. (1990) Interleukin 1 inhibits the ovarian steroid induced LH surge and release of hypothalamic LH-RH in rats. Endocrinology, 126, 2145-2152.
58. Kalter, H. (1987) Diabetes and spontaneous abortion: a historical review. Am. J. Obstet. Gynecol., 156, 1243-1253.
59. Kauma, S., Matt, D., Strom, S. et al. (1990) IL 1β, HLA DRα and TGF-β expression in endometrium, placenta and placental membranes. Am. J. Obstet. Gynaecol., 163, 1430-1437.
60. Keye, W. (1994) Psychologie relationships. Clin. Obstet. Gynaecol., 37, 671-680.
61. Kilian, P.L., Kaffka, K.L., Stern, A.S. et al. (1986) Interleukin 1α and interleukin 1β bind to the same receptor on T cells. J. Immunol., 136, 4509-14.
62. Kilpatrick, D.C. and Liston, W.A. (1995) Investigation of recurrent miscarriage. Hum. Reprod., 10, 694-695.
63. Knabbe, C., Lippman, M.E., Wakefield, L.M. et al. (1987) Evidence that transforming growth factor β is a hormonally regulated negative growth factor in human breast cancer cells. Cell, 48, 417-428.
64. Kronke, M., Hensel, G., Schluter, C. et al. (1988) Tumor necrosis factor and lymphotoxin gene expression in human tumor cell lines. Cancer Res., 48, 5417-5421.
65. Lagage, M., Maroc, N., Dubreuil, P. et al. (1987) The human interleukin 1α gene is located on the long arm of chromosome 2 at band q13. Blood, 73, 104-107.
66. Laird, S.M., Li, T.C. and Bolton, A.E. (1993) The production of placental protein 14 and interleukin 6 by human endometrial cells in culture. Hum. Reprod., 8, 793-798.
67. Lee, C.S. (1987) Luteal phase defect. Obstet. Gynecol. Surv., 42, 267-274.
68. Li, T.C., Serle, E., Warren, M.A. and Cooke, I.D. (1993) Is endometrial development in the peri-implantation period influenced by high concentrations of luteinizing hormone in the follicular phase? Hum. Reprod., 8, 1021-1024.
69. Li, Z.G., Danis, V.A. and Brooks, P.M. (1992) Effect of gonadal steroids on the production of IL 1 and IL 6 by blood mononuclear cells in vitro. Clin. Exp. Rheumatol., 11, 157-162.
70. Lockshin, M.D., Druzin, M.L., Goei, S. et al. (1985) Antibody to cardiolipin as a predictor of fetal distress or death in pregnant patients with SLE. N. Engl. J. Med., 313, 152-156.
71. Lomedico, P.T., Kilian, P.L., Gubler, U. et al. (1986) Molecular biology of interleukins. Cold Spring Harbor Symp. Quant. Biol., 51, 631-639.
72. Loy, R.A., Loukides, J.A., Polan, M.L. (1992) Ovarian steroids modulate human monocyte tumour necrosis factor alpha messenger ribonucleic acid levels in cultured human peripheral monocytes. Fertil. Steril., 58, 733-739.
73. Lubbe, W.F., Butler, W.S., Palmer, S.J. and Liggins, G.C. (1984) Lupus anticoagulant in pregnancy. Br. J. Obstet. Gynaecol., 91, 357-363.
74. Mallmann, P., Mallmann, R. and Krebs, D. (1991) Determination of tumour necrosis factor alpha and interleukin 2 in women with idiopathic recurrent miscarriage. Archiv. Gynecol. Obstet., 249, 73-78.
75. Marquette, C., Ban, E., Fillon, G. and Haour, F. (1990) Receptors for interleukin 1, 2 and 6 in mouse, rat and human pituitary. Neuroendocrinology, 52, 48.
76. Massague, J. (1992) Receptors for the TGF-beta family. Cell, 69, 1067-1070.
77. McNeely, M.J. and Soules, M.R. (1989) The diagnosis of luteal phase deficiency: a critical review. Fertil. Steril., 51, 582-587.
78. Medawar, P.B. (1953) Some immunological and endocrinological problems raised by evolution of viviparity in vertebrates. Symp. Soc. Exp. Biol., 7, 320-338.
79. Miller, D.A., Pelton, R.W., Derynck, R. and Moses H.L. (1990) Transforming growth factor β: A family of growth regulatory peptides. Ann. N.Y. Acad. Sci., 593, 208-217.
80. Mills, J.L., Simpson, J.L., Driscoll, S.G. et al. (1988) Incidence of spontaneous abortion among normal women and insulin dependant diabetic women whose pregnancies were identified within 21 days of conception. N. Engl. J. Med., 319, 1617-1623.
81. Miodovnik, M., Lavin, J.P., Knowles, H.C. et al. (1984) Spontaneous abortion among insulin dependant diabetic women. Am. J. Obstet. Gynecol., 150, 372-376.
82. Mizel, S.B., Kilian, P.L., Lewis, J.C. et al. (1987) The interleukin 1 receptor. Dynamics of interleukin 1 binding and internalisation in T cells and fibroblasts. J. Immunol., 138, 2906-2912.
83. Moghissi, K.S. (1982) What causes habitual abortion? Contemp. Ob. Gyn., 20, 45.
84. Mosmann, T.R., Cherwinski, H., Bond, M.W. et al. (1986) Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins. J. Immunol., 136, 2348-2357.
85. Mulheron, G.W. and Schomberg, D.W. (1990) Rat granulosa cells express transforming growth factor beta type 2 messenger ribonucleic acid which is regulatable by follicle stimulating hormone in vitro. Endocrinology, 126, 1777-1779.
86. Nabel, C. (1989) Malimplantation: a cause of failure after IVF and ET. Am. J. Reprod. Immunol., 6, 56-57.
87. Nedwin, G.E., Jarett-Nedwin, J., Smith, D.H. et al. (1985a) Structure and chromosomal localization of the human lymphotoxin gene. J. Cell. Biochem., 29, 171-181.
88. Nedwin, G.E., Naylor, S.L., Sakaguchi, A.Y. et al. (1985b) Human lymphotoxin and tumor necrosis factor genes: structure, homology and chromosomal localization. Nucleic Acids Res., 13, 6361-6373.
89. Neppert, J., Mueller-Eckhardt, G., Neumeyer, H. et al. (1989) Pregnancy maintaining antibodies: workshop report (Giessen, 1988). J. Reprod. Immunol., 15, 159-167.
90. Nilsson, I.M., Astedt, B., Hedner, U. and Berezin, D. (1975) Intrauterine death and circulating anticoagulant, 'antithromboplastin' Acta. Med. Scand., 197, 153-159.
91. Nishino, E., Matsuzaki, N., Masuhiro, K. et al. (1990) Trophoblast derived IL 6 regulates hCG release through IL 6 receptor on human trophoblasts. J. Clin. Endocrinol. Metab., 71, 436-441.
92. Noyes, R.W., Hertig, A.T. and Rock, J. (1950) Dating the endometrial biopsy. Fertil. Steril., 1, 3-10.
93. Ojeda, S.R., Urbanski, H.F., Costa, M.E. et al. (1990) Involvement of transforming growth factor alpha in release of LH-RH from the developing female hypothalamus. Proc. Natl. Acad. Sci. USA, 87, 9698-9702.
94. Oppenheim, J.J., Kovacs, E.J., Matsushima, K. and Durum, S.K. (1986) There is more than one interleukin 1. Immunol. Today, 7, 45-56.
95. Out, H.J., Kooijman, C.D., Bruinse, H.W. and Derksen, R.H.W.M. (1991) Histopathological findings from patients with intrauterine fetal death and antiphospholipid antibodies. Eur. J. Obstet. Gynaecol., 41, 179-186.
96. Park, M.I., Edwin, S.S., Scott, J.R. and Branch, D.W. (1990) Interpretation of blocking activity in maternal serum depends on the equation used for calculation of mixed lymphocyte culture results. Clin. Exp. Immunol., 82, 363-368.
97. Patton, P.E. (1994) Anatomic uterine defects. Clin. Obstet. Gynaecol., 37, 705-721.
98. Paulesu, L., King, A., Loke, Y.W. et al. (1991) Immunohistochemical localisation of IL 1 alpha and beta in normal human placenta. Lymphokine Cytokine Res., 10, 443-448.
99. Pestka, S. and Langer, J.A. (1987) Interferons and their actions. Ann. Rev. Chem, 56, 727-777.
100. Philippaeaux, M.M. and Piguet, P.F. (1993) Expression of tumour necrosis factor alpha and its mRNA in the endometrial mucosa during the menstrual cycle. Am. J. Pathol., 143, 480-486.
101. Quaglino, Jr D., Nanney, L.B., Kennedy, R. and Davidson, J.M. (1990) Transforming growth factor β stimulates wound healing and modulates extracellular matrix gene expression in pig skin. Excisional wound model. Lab. Invest., 63, 307-319.
102. Ralston, S.H., Russell, R.G.G. and Gowen, M. (1990) Estrogen inhibits release of tumour necrosis factor from peripheral blood mononuclear cells in postmenopausal women. J. Bone. Mineral. Res., 5, 983-988.
103. Ratner, L., Polmar, S.H., Paul, N. et al. (1987) Cytotoxic factors secreted by cells infected by human immunodeficiency virus type I. AIDS Res. Hum. Retroviruses, 3, 147-155.
104. Regan, L., Owen, E.J. and Jacobs, H.S. (1990) Hypersecretion of LH, infertility and miscarriage. Lancet, ii, 1141-1144.
105. Reshef, E., Lei, Z.M., Rao, C.V. et al. (1990) The presence of gonadotrophin receptors in non pregnant uterus, human placenta, fetal membranes and decidua. J. Clin. Endocrinol. Metab, 70, 421-430.
106. Robertson, A., Brannstrom, M. and Seamark, R.F. (1992) Cytokine in rodent reproduction and the cytokine-endocrine interaction. Curr. Opin. Immunol., 4, 585-590.
107. Rodger, J.C. (1985) Lack of a requirement for a maternal humoral immune response to establish or maintain successful allogenic pregnancy. Transplantation, 40, 372-375.
108. Romero, R., Wu, K.Y., Brody, D.R. et al. (1989) Human decidua: a source of IL 1. Obstet. Gynecol., 73, 31-34.
109. Salat-Baroux, J. (1988) Recurrent spontaneous abortions. Reprod. Nutr. Dev., 28, 1555-1568.
110. Scarborough, D.E. (1990) Cytokine modulation of pituitary hormone secretion. Ann. N.Y. Acad. Sci., 594, 169-187.
111. Schmid, S., Hornung, R., McGrath, K.M. et al. (1987) Target cell DNA fragmentation is mediated by lymphotoxin and tumor necrosis factor. Lymphokine Res., 6, 195-202.
112. Schoenfeld, H.J., Poeschl, B., Frey, J.R. et al. (1991) Efficient purification of recombinant human tumor necrosis factor beta from Escherichia coli yields biologically active protein with a trimeric structure that binds to both tumor necrosis factor receptors. J. Biol. Chem., 266, 3863-3869.
113. Serle, E., Aplin, J., Li, T.C. et al. (1994) Endometrial differentiation in the peri-implantation phase of women with recurrent miscarriage: a morphological and immunohistochemical study. Fertil. Steril., 62, 989-996.
114. Silver, R.M., Draper, M.L., Byrne, J.L.B. et al. (1994) Unexplained elevations of maternal serum AFP in women with antiphospholipid antibodies: a harbinger of fetal death. Obstet. Gynecol., 83, 150-155.
115. Simón, C., Piquette, G.N., Frances, A. and Polan, M.L. (1993) Localisation of interleukin 1 type receptor and interleukin 1 β in human endometrium throughout the menstrual cycle. J. Clin. Endocrinol. Metab., 77, 549-555.
116. Simón, C., Frances A., Piquette G. et al. (1994a) Embryonic implantation in mice is blocked by interleukin 1 receptor antagonist. Endocrinology, 134, 519-520.
117. Simón, C., Frances, A., Piquette, G. et al. (1994b) Interleukin 1 system in the materno-trophoblast unit in human implantation: immunohistochemical evidence for autocrine/paracrine function. J. Clin. Endocrin. Metab., 78, 847-854.
118. Simón, C., Frances, A., Pellicer, A. and Polan, M.L. (1995) Cytokines in implantation. Sem. Reprod. Endocrinol, 13, 142.
119. Skinner, M.K., Keski-Oja, J., Oskeen, K.G. and Moses, H.L. (1987) Ovarian thecal cells produce transforming growth factor beta which can regulate granulosa cell growth. Endocrinology, 121, 786-792.
120. Smith, J.W. 2nd, Urba, W.J., Curti, B.D. et al. (1992) The toxic and hematologic effects of interleukin-1 alpha administered in a phase I trial to patients with advanced malignancies. J. Clin. Oncol., 10, 1141-1152.
121. Solary, E., Prud'Homme, J.F., Magglelenat, H. and Calvo, F. (1991) Modulation of proliferation, estradiol receptors and estrogen regulated protein PS2/BCEI in human breast cancer lines by gamma interferon. J. Br. Regul. Homeost. Agents, 5, 98-106.
122. Sporn, M.B., Roberts, A.B. (1990) The transforming growth factor betas: past, present and future. Ann. N.Y. Acad. Sci., 593, 1-6.
123. Stagnaro-Green, A., Roman, S.H., Cobin, R.H. et al. (1990) Detection of at risk pregnancy by means of highly sensitive assays for thyroid autoantibodies. J. Am. Med. Assoc., 264, 1422-1425.
124. Stirrat, G.M. (1990) Recurrent miscarriage: its definition and epidemiology. Lancet, 336, 673-675.
125. Summers, P.R. (1994) Microbiology relevant to recurrent miscarriage. Clin. Obstet. Gynaecol., 37, 722-729.
126. Swain, S.L., Huston, G., Tonkonogy, S. and Weinberg, A.D. (1991) Transforming growth factor-beta and IL-4 cause helper T cell precursors to develop into distinct effector helper cells that differ in lymphokine secretion pattern and cell surface phenotype. J. Immunol., 147, 2991-3000.
127. Tabibzadeh, S. (1990) Evidence of T cell activation and potential cytokine action in human endometrium. J. Endocrinol. Metab., 71, 645-649.
128. Tabibzadeh, S. (1991a) Human endometrium: an active site of cytokine production and action. Endocrinol. Rev., 12, 272-290.
129. Tabibzadeh, S.S. (1991b) Ubiquitous expression of TNF α/cachectin in human endometrium. Am. J. Rep. Immunol., 26, 1-5.
130. Tabibzadeh, S.S. (1994) Cytokines and the hypothalamic pituitary-ovarian-endometrial axis. Hum. Reprod., 9, 947-967.
131. Tabibzadeh, S.S. and Satyaswaroop, P.G. (1989) Sex steroid receptors in lymphoid cells of human endometrium. Am. J. Clin. Pathol., 91, 656-663.
132. Tabibzadeh, S. and Sun, X.Z. (1992) Cytokine expression in human endometrium throughout the menstrual cycle. Hum. Reprod., 7, 1214-1221.
133. Tabibzadeh, S.S., Santhanam, U., Sehgal, P.B. and May, L. (1989) Cytokine induced production of interferon β2/interleukin 6 by freshly explanted human endometrial stromal cells: modulation by estradiol 17β. J. Immunol., 142, 3134-3139.
134. Taga, T., Hibi, M., Hirata, Y. et al. (1989) Interleukin-6 triggers the association of its receptor with a possible signal transducer, gp130. Cell, 58, 573-581.
135. Tamada, H., McMaster, M.T., Flanders, K.C. et al. (1990) Cell type specific expression of transforming growth factor β1 in the mouse uterus during preimplantation period. Mol. Endocrinol., 4, 965-972.
136. Tangri, S. and Raghupathy, R. (1993) Expression of cytokines in placentas of mice undergoing immunologically mediated spontaneous fetal resorptions. Biol. Reprod., 49, 850-856.
137. Tangri, S., Wegmann, T.G., Lin, H. and, Raghupathy, R. (1994) Maternal anti-placental reactivity in natural, immunologically mediated spontaneous fetal resorptions. J. Immunol., 152, 4903-4911.
138. Tho, P.T., Byrd, J.R. and McDonough, P.G. (1979) Etiologies and subsequent reproductive performance of 100 couples with recurrent abortion. Fertil. Steril., 32, 389-395.
139. Thompson, N.L., Flanders, K.C., Smith, J.M. et al. (1989) Expression of transforming growth factor beta 1 in specific cells and tissues of adult and neonatal mice. J. Cell. Biol., 108, 661-669.
140. Thorbecke, G.J., Shab, R., Leu, C.H. et al. (1992) Involvement of endogenous tumour necrosis factor alpha and transforming growth factor beta during induction of collagen type II arthritis in mice. Proc. Natl. Acad. Sci. USA, 89, 7375-7379.
141. Tracey, K.J. and Lowry, S.F. (1990) The role of cytokine mediators in septic shock. [Review]. Adv. Surg., 23, 21-56.
142. Tschachler, E., Rober-Gurroff, M., Gallo, R.C. et al. (1989) Human T-lymphotropic virus I-infected T cells constitutively express lymphotoxin in vitro. Blood, 73, 194-201.
143. Tulpalla, M., Stenman, U.H., Cacciatore, B. and Ylikorkala, O. (1993) Polycystic ovaries and levels of gonadotrophins and androgens in recurrent miscarriage: prospective study in 50 women. Br. J. Obstet. Gynaecol., 100, 348-352.
144. Wang, A.M., Creasey, A.A., Ladner, M.B. et al. (1985) Molecular cloning of the complementary DNA for human tumor necrosis factor. Science, 228, 149-154.
145. Warburton, D. and Strobino, B. (1987) Recurrent spontaneous abortion. In Bennett, M.J. and Edmonds, D.K. (eds), Spontaneous and Recurrent Abortion. Blackwell Scientific, Oxford, pp. 193-213.
146. Watson, H., Kiddy, D.S., Hamilton-Fairley, D. et al. (1993) Hypersecretion of LH and ovarian steroids in women with recurrent early miscarriage. Hum. Reprod., 8, 829-833.
147. Webb, A.C., Collins, K.L., Auron, P.E. et al. (1986) Interleukin 1 gene (IL 1) assigned to long arm of human chromosome 2. Lymphokine. Res., 5, 77-85.
148. Wegmann, T.G. (1984) Fetal protection against abortion: is it immuno-suppression or immuno-stimulation? Ann. Immunol. (Inst Pasteur), 135, 309-312.
149. Wegmann, T.G., Lin, H., Guilbert, L. and Mosmann, T.R. (1993) Bidirectional cytokine interactions in the maternal-fetal relationship: is successful pregnancy a TH 2 phenomenon? Immunol. Today, 14, 353-356.
150. Yamaguchi, M., Matsuzaki, N., Hirota, K. et al. (1990a) Interleukin 6 possibly induced by interleukin 1β in the pituitary gland stimulates the release of gonadotropins and prolactin. Acta Endocrinol., 122, 201-205.
151. Yamaguchi, M., Sakata, M., Matsuzaki, N. et al. (1990b) Induction by TNF alpha of rapid release of immunoreactive and bioactive luteinizing hormone from rat pituitary cells in vitro. Neuroendocrinology, 52, 468-472.
152. Yamoda, H., Polgar, K., Hill, J.A. (1994) Cell mediated immunity to trophoblast antigens in women with recurrent spontaneous abortion. Am. J. Obstet. Gynecol., 170, 1339-1344.