Pointing (zinc) fingers at BRCA1 targets

Nature Medicine

Volumn 6, Issue 12, 2000, Pages 1318-1319

  MacLachlan, T K ^a   El Deiry, W S ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ESTROGEN RECEPTOR; PROTEIN P53; ZINC FINGER PROTEIN;

BREAST CANCER; CANCER FAMILY; CANCER RISK; CANCER SUSCEPTIBILITY; CONTROLLED STUDY; DNA DAMAGE; GENE EXPRESSION; GENE MUTATION; GENE TARGETING; HUMAN; HUMAN CELL; KNOCKOUT GENE; ONCOGENE; PRIORITY JOURNAL; SHORT SURVEY; TUMOR SUPPRESSOR GENE;

ANIMALS; BRCA1 PROTEIN; BREAST NEOPLASMS; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; GENETIC PREDISPOSITION TO DISEASE; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MICE; OVARIAN NEOPLASMS; PROTEIN BINDING; PROTEINS; ZINC FINGERS;

EID: 0034534868     PISSN: 10788956     EISSN: None     Source Type: Journal    
DOI: 10.1038/82119     Document Type: Short Survey

References (8)

1. A strong candidate for the breast and ovarian cancer susceptibility gene BRCA1
2. BRCA1: Exploring the links to transcription
3. Sequence-specific transcriptional corepressor function for BRCA1 through a novel zinc finger protein, ZBRK1
4. Induction of GADD45- and INK/SAPK-dependent apoptosis following inducible expression of BRCA1
5. BRCA1 effects on the cell cycle and the DNA damage response are linked to altered gene expression
6. Functional link of BRCA1 and ataxia telangiectasia gene product in DNA damage response
7. Repression of BRCA1 through a Feedback Loop Involving p53
8. Tumor suppressor p53 is required to modulate BRCA1 expression