Molecular mechanism of activation and superactivation of Ret tyrosine kinases by ultraviolet light irradiation

Antioxidants and Redox Signaling

Volumn 2, Issue 4, 2000, Pages 841-849

  Kato, M ^a   Iwashita, T ^a   Akhand, A A ^a   Liu, W ^a   Takeda, K ^a   Takeuchi, K ^a   Yoshihara, M ^a   Hossain, K ^a   Wu, J ^a   Du, J ^a   Oh, C ^a   Kawamoto, Y ^a   Suzuki, H ^a   Takahashi, M ^a   Nakashima, I ^a  

^a NAGOYA UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE; CYSTEINE; GENE PRODUCT; HYBRID PROTEIN; PROTEIN RET; PROTEIN RFP; PROTEIN TYROSINE KINASE; UNCLASSIFIED DRUG;

AMINO ACID SUBSTITUTION; CATALYSIS; DIMERIZATION; DISULFIDE BOND; ENZYME ACTIVATION; ENZYME ACTIVITY; GENE MUTATION; HUMAN; HYBRID GENE; MALIGNANT TRANSFORMATION; NONHUMAN; ONCOGENE RET; PAPILLARY CARCINOMA; PATHOGENESIS; POLYMERIZATION; PRIORITY JOURNAL; RADIATION INJURY; REVIEW; SIPPLE SYNDROME; THYROID CARCINOMA; TRANSGENIC MOUSE; ULTRAVIOLET RADIATION;

EID: 0034534534     PISSN: 15230864     EISSN: None     Source Type: Journal    
DOI: 10.1089/ars.2000.2.4-841     Document Type: Review

References (29)

1. Mechanism of activation of the ret proto-oncogene by multiple endocrine neoplasia 2A mutations
2. Single missense mutation in the tyrosine-kinase catalytic domain of the RET proto-oncogene is associated with multiple endocrine neoplasia type 2B
3. Signaling of the Ret receptor tyrosine kinase through the c-Jun NH2-terminal protein kinases (JNKS): Evidence for a divergence of the ERKs and JNKs pathways induced by Ret
4. UV activation of receptor tyrosine kinase activity
5. The mammalian ultraviolet response is triggered by activation of Src tyrosine kinases
6. Mutations in the RET proto-oncogene are associated with MEN2A and FMTC
7. PTC is a novel rearranged form of the ret proto-oncogene and is frequently detected in vivo in human thyroid papillary carcinomas
8. A ring finger motif regulates transforming activity of the rfp/ret fusion gene
9. A mutation in the RET proto-oncogene associated with multiple endocrine neoplasia type 2B and sporadic medullary thyroid carcinoma
10. cDNA cloning and characterization of ret activated in a human papillary thyroid carcinoma cell line
11. Aberrant melanogenesis and melanocytic tumour development in transgenic mice that carry a metallothionein/ret fusion gene
12. The herbal medicine Sho-saiko-to inhibits growth and metastasis of malignant melanoma primarily developed in ret-transgenic mice
13. Transgenic mouse model for skin malignant melanoma
14. Linkage between melanocytic tumor development and early burst of Ret protein expression for tolerance induction in metallothionein-I/ret transgenic mouse lines
15. Ultraviolet light induces redox reaction-mediated dimerization and superactivation of oncogenic Ret tyrosine kinases
16. Dephosphorylation of receptor tyrosine kinase as target of regulation by radiation, oxidants or alkylating agents
17. Speculations on the role of ultraviolet radiation in the development of malignant melanoma
18. Germline mutations of the RET proto-oncogene in multiple endocrine neoplasia type 2A
19. Ultraviolet light and osmotic stress: Activation of the JNK cascade through multiple growth factor and cytokine receptors
20. Activation of RET as a dominant transforming gene by germline mutations of MEN2A and MEN2B
21. Defects in the kidney and enteric nervous system of mice lacking the tyrosine kinase receptor Ret
22. 2-induced T cell signal transduction
23. Clustered cysteine residues in the kinase domain of v-Src: Critical role for protein stability, cell transformation and sensitivity to herbimycin A
24. Oncogenic activation of the ret protooncogene in thyroid cancer
25. The role of the ret proto-oncogene in human disease
26. ret transforming gene encodes a fusion protein homologous to tyrosine kinases
27. Conserved cysteine residues are critical for the enzymatic function of the lymphocyte-specific tyrosine protein kinase p56lck
28. Ultraviolet radiation induces phosphorylation of the epidermal growth factor receptor
29. Sunburn and p53 in the onset of skin cancer