Ultraviolet light induces redox reaction-mediated dimerization and superactivation of oncogenic Ret tyrosine kinases

Molecular Biology of the Cell

Volumn 11, Issue 1, 2000, Pages 93-101

  Kato, Masashi ^a   Iwashita, Toshihide ^a   Takeda, Kozue ^a   Akhand, Anwarul A ^a   Liu, Wei ^a   Yoshihara, Motoi ^a   Asai, Naoya ^a   Suzuki, Haruhiko ^a   Takahashi, Masahide ^a   Nakashima, Izumi ^a  

^a NAGOYA UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

PROTEIN TYROSINE KINASE; SUPEROXIDE DISMUTASE;

AMINO ACID SUBSTITUTION; ARTICLE; AUTOPHOSPHORYLATION; DIMERIZATION; DISULFIDE BOND; GENE ACTIVATION; GENE ACTIVITY; GENE CONTROL; GENE MUTATION; GENE OVEREXPRESSION; OXIDATION REDUCTION REACTION; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTO ONCOGENE; ULTRAVIOLET RADIATION;

EID: 0033973130     PISSN: 10591524     EISSN: None     Source Type: Journal    
DOI: 10.1091/mbc.11.1.93     Document Type: Article

References (29)

1. Asai, N., Iwashita, T., Matsuyama, M., and Takahashi, M. (1995). Mechanism of activation of the ret proto-oncogene by multiple endocrine neoplasia 2A mutations. Mol. Cell. Biol. 15, 1613-1619.
2. Carlson, K.M., Dou, S., Chi, D., Scavarda, N., Toshima, K., Jackson, C.E., Wells, S.A., Jr., Goodfellow, P.J., and Donis-Keller, H. (1994). Single missense mutation in the tyrosine-kinase catalytic domain of the RET proto-oncogene is associated with multiple endocrine neoplasia type 2B. Proc. Natl. Acad. Sci. USA 91, 1579-1583.
3. Chiariello, M., et al. (1998). Signaling of the Ret receptor tyrosine kinase through the c-Jun NH2-terminal protein kinases (JNKS): evidence for a divergence of the ERKs and JNKs pathways induced by Ret. Oncogene 16, 2435-2445.
4. Coffer, P.J., Burgering, B.M., Peppelenbosch, M.P., Bos, J.L., and Kruijer, W. (1995). UV activation of receptor tyrosine kinase activity. Oncogene 11, 561-569.
5. Devary, Y., Gottlieb, R.A., Smeal, T., and Karin, M. (1992). The mammalian UV response is triggered by activation of Src tyrosine kinases. Cell 71, 1081-1091.
6. Dhanwada, K.R., Dickens, M., Neades, R., Davis, R., and Pelling, J.C. (1995) Differential effects of UV-B and UV-C components of solar radiation on MAP kinase signal transduction pathways in epidermal keratinocytes. Oncogene 11, 1947-1953.
7. Donis-Keller, H., Dou, S., Chi, D., Carlson, K.M., Toshima, T., Laimore, T.C., Howe, J.R., Moley, J.F., Goodfellovv, P., and Wells, S.A., Jr. (1993). Mutations in the RET proto-oncogene are associated with MEN 2A and FMTC. Hum. Mol. Genet. 2, 851-856.
8. Flanagan, J.G., and Leder, P. (1990). The kit ligand: a cell surface molecule altered in steel mutant fibroblasts. Cell 63, 185-194.
9. Grieco, M., Santoro, M., Berlingieri, M.T., Melillo, R.M., Donghi, R., Bongarzone, I., Pierotti, M.A., Della Porta, G., Fusco, A., and Vecchio, G. (1990). PTC is a novel rearranged form of the ret proto-oncogene and is frequently detected in vivo in human thyroid papillary carcinomas. Cell 60, 557-563.
10. Hofstra, R.M.W., et al. (1994). A mutation in the RET proto-oncogene associated with multiple endocrine neoplasia type 2B and sporadic medullary thyroid carcinoma. Nature 367, 375-376.
11. Ishizaka, Y., Ushijima, T., Sugimura, T., and Nagao, M. (1990). cDNA cloning and characterization of ret activated in a human papillary thyroid carcinoma cell line. Biochem. Biophys. Res. Commun. 168, 402-408.
12. Iwamoto, T., Takahashi, M., Ito, M., Hamatani, K., Ohbayashi, M., Wajjwalku, W., Isobe, K., and Nakashima, I. (1991). Aberrant melanogenesis and melanocytic tumor development in transgenic mice that carry a metallothionein/ret fusion gene. EMBO J. 10, 3167-3175.
13. Iwashita, T., Asai, N., Murakami, H., Matsuyama, M., and Takahashi, M. (1996). Identification of tyrosine residues that are essential for transforming activity of the ret proto-oncogene with MEN2A or MEN2B mutation. Oncogene 12, 481-487.
14. Kato, M., Liu, W., Akhand, A.A., Dai, Y., Ohbayashi, M., Tuzuki, T., Suzuki, H., Isobe, K., Takahashi, M., and Nakashima, I. (1999). Linkage between melanocytic tumor development and early burst of Ret protein expression for tolerance induction in metallothionein-I/ret transgenic mouse lines. Oncogene 18, 837-842.
15. Kato, M., Liu, W., Yi, H., Asai, N., Hayakawa, A., Kozaki, K., Takahashi, M., and Nakashima, I. (1998a). The herbal medicine Sho-saiko-to inhibits growth and metastasis of malignant melanoma primarily developed in ret-transgenic mice. J. Invest. Dermatol. 111, 640-644.
16. Kato, M., Takahashi, M., Akhand, A.A., Liu, W., Dai, Y., Shimizu, S., Iwamoto, T., Suzuki, H., and Nakashima, I. (1998b). Transgenic mouse model for skin malignant melanoma. Oncogene 17, 1885-1888.
17. Knebel, A., Rahmsdorf, H.J., Ullrich, A., and Herrlich, P. (1996). Dephosphorylation of receptor tyrosine kinase as target of regulation by radiation, oxidants or alkylating agents. EMBO J. 15, 5314-5325.
18. Mulligan, L.M., et al. (1993). Germ-line mutations of the RET proto-oncogene in multiple endocrine neoplasia type 2A. Nature 363, 458-460.
19. Rosette, C., and Karin, M. (1996). UV light and osmotic stress: activation of the JNK cascade through multiple growth factor and cytokine receptors. Science 274, 1194-1197.
20. Sachsenmaier, C., Radler-Pohl, A., Zinck, R., Nordheim, A., Herrlich, P., and Rahmsdorf, H.J. (1994). Involvement of growth factor receptors in the mammalian UVC response. Cell 78, 963-972.
21. Santoro, M., et al. (1995). Activation of RET as a dominant transforming gene by germline mutations of MEN2A and MEN2B. Science 267, 381-383.
22. 2-induced T cell signal transduction. J. Biol. Chem. 269, 20718-20726.
23. Schuchardt, A., D'Agati, V., Larsson-Blomberg, L., Costantini, F., and Pachnis, V. (1994). Defects in the kidney and enteric nervous system of mice lacking the tyrosine kinase receptor Ret. Nature 367, 380-383.
24. Senga, T., Miyazaki, K., Machida, K., Iwata, H., Matsuda, S., Nakashima, I., and Hamaguchi, M. (2000). Clustered cysteine residues in the kinase domain of v-Src: critical role for protein stability, cell transformation and sensitivity to herbimycin A. Oncogene (in press).
25. Takahashi, M. (1995). Oncogenic activation of the ret protooncogene in thyroid cancer. Crit. Rev. Oncogenesis 6, 35-46.
26. Takahashi, M. (1997). The role of the ret proto-oncogene in human disease. Nagoya J. Med. Sci. 60, 23-30.
27. Takahashi, M., Asai, N., Iwashita, T., Isomura, T., Miyazaki, K., and Matsuyama, M. (1993). Characterization of the ret proto-oncogene products expressed in mouse L cells. Oncogene 8, 2925-2929.
28. Veillette, A., Dumont, S., and Fournel, M. (1993). Conserved cysteine residues are critical for the enzymatic function of the lymphocyte-specific tyrosine protein kinase p56lck. J. Biol. Chem. 268, 17547-17553.
29. Warmuth, I., Harth, Y., Matsui, M.S., Wang, N., and DeLeo, V.A. (1994). UV radiation induces phosphorylation of the epidermal growth factor receptor. Cancer Res. 54, 374-376.