Evaluation of the pharmacokinetics and electrocardiographic pharmacodynamics of loratadine with concomitant administration of ketoconazole or cimetidine

British Journal of Clinical Pharmacology

Volumn 50, Issue 6, 2000, Pages 581-589

  Kosoglou, T ^a   Salfi, M ^a   Lim, J M ^a   Batra, V K ^a   Cayen, M N ^a   Affrime, M B ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

Cimetidine; Electrocardiographic; Ketoconazole; Loratadine; Repolarization

Indexed keywords

CIMETIDINE; DESLORATADINE; KETOCONAZOLE; LORATADINE;

ABDOMINAL PAIN; ADULT; ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; DIARRHEA; DRUG BLOOD LEVEL; DRUG METABOLISM; DRUG SAFETY; DRUG TOLERABILITY; DYSPEPSIA; ELECTROCARDIOGRAPHY; GASTROINTESTINAL SYMPTOM; HEADACHE; HEART REPOLARIZATION; HUMAN; HUMAN EXPERIMENT; MALE; NAUSEA; NORMAL HUMAN; PHARMACODYNAMICS; PRIORITY JOURNAL; QT INTERVAL; RANDOMIZED CONTROLLED TRIAL; SINGLE BLIND PROCEDURE; VOMITING;

ADULT; ANTIFUNGAL AGENTS; CIMETIDINE; CONSUMER PRODUCT SAFETY; CROSS-OVER STUDIES; DRUG INTERACTIONS; ELECTROCARDIOGRAPHY; HISTAMINE H1 ANTAGONISTS; HISTAMINE H2 ANTAGONISTS; HUMANS; KETOCONAZOLE; LORATADINE; MALE; SINGLE-BLIND METHOD;

EID: 0034533744     PISSN: 03065251     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2125.2000.00290.x     Document Type: Article

References (23)

1. Torsades de pointes associated with terfenadine in a case of liver cirrhosis and hepatocellular carcinoma
2. Torsades de pointes occurring in association with terfenadine use
3. Inhibition of terfenadine metabolism in vitro by azole antifungal agents and by selective serotonin reuptake inhibitor antidepressants: Relation to pharmacokinetic interactions in vivo
4. Torsades de pointes ventricular tachycardia associated with overdose of astemizole
5. Torsades de pointes complicating treatment with terfenadine
6. Changes in the pharmacokinetics and electrocardiographic pharmacodynamics of terfenadine with concomitant administration of erythromycin
7. Terfenadine-ketoconazole interaction. Pharmacokinetic and electrocardiographic consequences [published erratum appears in JAMA 1993; 269: 2088]
8. Astemizole-induced torsade de pointes
9. Warnings issued on the nonsedating antihistamines terfenadine and astemizole
10. Identification of human liver cytochrome P450s involved in the microsomal metabolism of the antihistaminic drug loratadine
11. Loratadine administered concomitantly with erythromycin: Pharmacokinetic and electrocardiographic evaluations
12. Differential inhibition of individual human liver cytochromes P-450 by cimetidine
13. [Serum IgE in patients suffering from IgA deficiency with or without atopy]
14. Pharmacokinetics
15. Sensitive gas-liquid chromatographic method for the determination of loratadine and its major active metabolite, descarboethoxyloratadine, in human plasma using a nitrogen-phosphorus detector
16. Risks of non-sedating antihistamines
17. Dangers of non-sedating antihistamines
18. Pharmacokinetics and dose proportionality of loratadine
19. Suppression of mammalian K+ channel family by ebastine
20. Comparative effects of loratadine and terfenadine on cardiac K+ channels
21. Regulation of potassium channels by nonsedating antihistamines
22. Antihistamine activity, central nervous system and cardiovascular profiles of histamine H1 antagonists: Comparative studies with loratadine, terfenadine and sedating antihistamines in guinea-pigs
23. Three month evaluation of electrocardiographic effects of loratadine in humans