A pilot study of N-acetyl glucosamine, a nutritional substrate for glycosaminoglycan synthesis, in paediatric chronic inflammatory bowel disease

Alimentary Pharmacology and Therapeutics

Volumn 14, Issue 12, 2000, Pages 1567-1579

  Salvatore, S ^a,b   Heuschkel, R ^a,b   Tomlin, S ^a,b   Davies, S E ^a,b   Edwards, S ^a,b   Walker Smith, J A ^a,b   French, I ^a,b   Murch, S H ^a,b,c  

^a ROYAL FREE AND UNIVERSITY COLLEGE MEDICAL SCHOOL   (United Kingdom)

^b Glucogenics Pharmaceuticals   (Canada)

^c ROYAL FREE HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

GLYCOPROTEIN; GLYCOSAMINOGLYCAN; METALLOPROTEINASE; N ACETYLGLUCOSAMINE;

ADOLESCENT; ARTICLE; CHILD; CHRONIC DISEASE; CLINICAL ARTICLE; COLON BIOPSY; DISEASE SEVERITY; DRUG EFFICACY; ENDOSCOPY; ENTERITIS; ENZYME ACTIVITY; FEMALE; FOLLOW UP; GLYCOSAMINOGLYCAN METABOLISM; HISTOCHEMISTRY; HUMAN; INTESTINE MUCOSA; LAMINA PROPRIA; MALE; NUTRIENT; PRIORITY JOURNAL; PROCTITIS; RADIODIAGNOSIS; REMISSION; TISSUE REPAIR; TREATMENT INDICATION;

ACETYLGLUCOSAMINE; ADMINISTRATION, ORAL; ADMINISTRATION, RECTAL; ADOLESCENT; ADRENAL CORTEX HORMONES; CHILD; CHRONIC DISEASE; COLITIS, ULCERATIVE; CROHN DISEASE; FEMALE; GLYCOSAMINOGLYCANS; HUMANS; MALE; PILOT PROJECTS;

EID: 0034533278     PISSN: 02692813     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2036.2000.00883.x     Document Type: Article

References (35)

1. Evidence of fibroblast heterogeneity and the role of fibroblast subpopulations in fibrosis
2. Disruption of sulphated glycosaminoglycans in intestinal inflammation
3. Alteration in glycosaminoglycan metabolism and surface charge on human umbilical vein endothelial cells induced by cytokines, endotoxin and neutrophils
4. Proteolytic degradation of intestinal mucosal extracellular matrix after lamina propria T cell activation
5. Mucosal TNF-α production and extensive disruption of sulfated glycosaminoglycans begin within hours of birth in neonatal respiratory distress syndrome
6. Localisation of tumour necrosis factor α by immunohisto-chemistry in chronic inflammatory bowel disease
7. Tumor necrosis factor-alpha producing cells in the intestinal mucosa of children with inflammatory bowel disease
8. A p55 TNF receptor-immunoadhesin prevents T cell-mediated intestinal injury by inhibiting matrix metalloprotease production
9. Early production of macrophage inflammatory protein-1α occurs in respiratory distress syndrome and is associated with poor outcome
10. A major role for matrix metalloproteinases in T cell injury in the gut
11. Tumor necrosis factor α antibody (infliximab) therapy profoundly downregulates the inflammation in Crohn's ileocolitis
12. Glycosaminoglycans and their binding to biological macromolecules
13. Architecture and matrix of the small intestine
14. Cytokine regulation of human lung hyaluronan (hyaluronic acid) production. Evidence for cytokine-regulated hyaluronan degradation and human lung fibroblast-derived hyaluronidase
15. Dermatan sulfate activates nuclear factor-κB and induces endothelial and circulating intercellular adhesion molecule-1
16. Alterations in nonhuman primate (M. nemestrina) lung proteoglycans during normal development and acute hyaline membrane disease
17. Fibrogenic cytokines and connective tissue production
18. Reversal of experimental autoimmune encephalomyelitis with a hydroxyamate inhibitor of matrix metalloproteases
19. Imbalance of stromelysin-1 and TIMP-1 mRNA and protein in the mucosal lesions of children with inflammatory bowel disease
20. 3H-N-acetyl glucosamine in the intestinal mucosa of patients with inflammatory bowel disease
21. Unifying hypothesis for inflammatory bowel disease and associated colon cancer: Sticking the pieces together with sugar
22. Dynamic O-linked glycosylation of nuclear and cytoskeletal proteins
23. Pilot study of oral polymeric N-acetyl-glucosamine as a potential treatment for patients with osteorthritis
24. Therapeutic activity of oral glucosamine sulfate in osteoarthrosis: A placebo-controlled double-blind investigation
25. Altered lectin binding by colonic epithelial glycoconjugates in ulcerative colitis and Crohn's disease
26. Hype about glucosamine
27. Glucosamine and acetyl-glucosamine tolerance in man
28. Mucosal glucosamine synthetase activity in inflammatory bowel disease
29. Glucosamine synthetase activity of the colonic mucosa in ulcerative colitis and Crohn's disease
30. Heparin, cell adhesion, and pathogenesis of inflammatory bowel disease
31. Inhibition of superoxide anion release from human polymorphonuclear leukocytes by N-acetyl-galactosamine and N-acetyl-glucosamine
32. Mannam and oligomers of N-acetylglucosamine protect intestinal mucosa of celiac patients with active disease from in vitro toxicity of gliadin peptides
33. Use of glycosaminoglycans to increase efficiency of long-term continuous peritoneal dialysis
34. N-acetyl glucosamine changes permeability of peritoneum during chronic peritoneal dialysis in rats
35. Prevention of post-operative abdominal adhesions by a sodium hyaluronate-based membrane: A prospective, randomized, double-blind multicenter study