Expression of the MRP and MDR1 multidrug resistance genes in small cell lung cancer

Clinical Cancer Research

Volumn 3, Issue 1, 1997, Pages 115-122

  Campling, Barbara G ^a,b   Young, Leah C ^a   Baer, Kathy A ^a   Lam, Yuk Miu ^a   Deeley, Roger G ^a   Cole, Susan P C ^a   Gerlach, James H ^a  

^a QUEEN S UNIVERSITY   (Canada)

^b Cancer Centre of South Eastern Ontario   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

CARBOPLATIN; CISPLATIN; CYCLOPHOSPHAMIDE; DOXORUBICIN; ETOPOSIDE; LOMUSTINE; MESSENGER RNA; METHOTREXATE; MITOXANTRONE; PROCARBAZINE; VINCRISTINE;

ARTICLE; CELL LINE; CONTROLLED STUDY; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; LUNG SMALL CELL CANCER; MULTIDRUG RESISTANCE; PLEURA EFFUSION; PRIORITY JOURNAL; RNA ANALYSIS;

CARCINOMA, SMALL CELL; DRUG RESISTANCE, MULTIPLE; DRUG RESISTANCE, NEOPLASM; DRUG SCREENING ASSAYS, ANTITUMOR; GENE EXPRESSION; GENES, MDR; HUMANS; LUNG NEOPLASMS; P-GLYCOPROTEIN; RNA, MESSENGER; TUMOR CELLS, CULTURED;

EID: 0031058811     PISSN: 10780432     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (25)

1. Ihde, D. G., Pass, H. I., and Glatstein, E. J. Small cell lung cancer. In: V. T. DeVita, Jr., S. Hellman, and S. A. Rosenberg (eds.), Cancer: Principles and Practice of Oncology, pp. 723-758. Philadelphia: J. B. Lippincott Co., 1993.
2. Bradley, G., Juranka, P., and Ling, V. Mechanism of multidrug resistance. Biochim. Biophys. Acta, 948: 87-128, 1988.
3. Gerlach, J. H. Structure and function of P-glycoprotein. In: R. F. Ozols (ed.), Drug Resistance in Cancer Therapy, pp. 37-52. Boston: Kluwer Academic Publishers, 1989.
4. Lai, S. L., Goldstein, L. J., Gottesman, M. M., Pastan, I., Tsai, C. M., Johnson, B. E., Mulshine, J. L., and Ihde, D. C. MDR1 gene expression in lung cancer. J. Natl. Cancer Inst., 81: 1144-1150, 1989.
5. Goldstein, L. J., Galski, H., Fojo, A., Willingham, M., Lai, S. L., Gazdar. A., Pirker, R., and Green, A. Expression of a multidrug resistance gene in human cancers. J. Natl. Cancer Inst., 81: 116-124, 1989.
6. Noonan, K. E., Beck, C., Holzmayer, T. A., Chin, J. E., Wunder, J. S., Andrulis, I. L., Gazdar, A. F., and Willman, C. L. Quantitative analysis of MDR1 (multidrug resistance) gene expression in human tumors by polymerase chain reaction. Proc. Natl. Acad. Sci. USA, 87: 7160-7164, 1990.
7. Milroy, R., Plumb, J. A., Batstone, P., Maclay, A., Wishart, G. C., Hay, F. G., Candlish, W., and Adamson, R. Lack of expression of P-glycoprotein in 7 small cell lung cancer cell lines established both from untreated and from treated patients. Anticancer Res., 12: 193-200, 1992.
8. Cole, S. P. C., Bhardwaj, G., Gerlach, J. H., Mackie, J. E., Grant, C. E., Almquist, K. C., Stewart, A. J., Kurz, E. U., Duncan, A. M. V., and Deeley, R. G. Overexpression of a transporter gene in a multidrug-resistant human lung cancer cell line. Science (Washington DC), 255: 1650-1654, 1992.
9. Grant, C. E., Valdimarsson, G., Hipfner, D. R., Almquist, K. C, Cole, S. P. C, and Deeley, R. G. Overexpression of multidrug resistance-associated protein (MRP) increases resistance to natural product drugs. Cancer Res., 54: 357-361, 1994.
10. Cole, S. P. C., Sparks, K. E., Fraser, K., Loe, D. W., Grant, C. E., Wilson, G. M., and Deeley, R. G. Pharmacological characterization of multidrug resistant MRP-transfected human tumor cells. Cancer Res., 54:5902-5910, 1994.
11. Campling, B. G., Haworth, A. C., Baker, H. M., Greer, D. L., Holden, J. J. A., Bradley, W. E. C., Pym, J., and Dexter, D. F. Establishment and characterization of a panel of human lung cancer cell lines. Cancer (Phila.), 69: 2064-2074, 1992.
12. Campling, B. G., Baer, K., Baker, H. M, Lam, Y. M., and Cole, S. P. C. Do glutathione and related enzymes play a role in drug resistance in small cell lung cancer cell lines? Br. J. Cancer, 68: 327-335, 1993.
13. Dalton, W. S., Durie, B. G. M., Alberts, D. S., Gerlach, J. H., and Cress, A. E. Characterization of a new drug-resistant human myeloma cell line that expresses P-glycoprotein. Cancer Res., 46: 5125-5130, 1986.
14. Mirski, S. E. L., Gerlach, J. H., and Cole, S. P. C. Multidrug resistance in a human small cell lung cancer cell line selected in Adriamycin. Cancer Res., 47: 2594-2598, 1987.
15. Campling, B. G., Pym, J., Baker, H. M., Cole, S. P. C., and Lam, Y. M. Chemosensitivity testing of small cell lung cancer using the MTT assay. Br. J. Cancer, 63: 75-83, 1991.
16. Cole, S. P. C. Multidrug resistance in human lung cancer. In: H. I. Pass, J. Mitchell, D. H. Johnson, and A. T. Turrisi (eds.), Lung Cancer. Principles and Practice, pp. 169-204, Philadelphia: J. B. Lippincott Company, 1996.
17. Reeve, J. G., Rabbitts, P. H., and Twentyman, P. R. Amplification and expression of mdr1 gene in a multidrug resistant variant of small cell lung cancer cell line NCI-H69. Br. J. Cancer, 60: 339-342, 1989.
18. Holzmayer, T. A., Hilsenbeck, S., Von Hoff, D. D., and Roninson, I. B. Clinical correlates of MDR1 (P-glycoprotein) gene expression in ovarian and small-cell lung carcinomas. J. Natl. Cancer Inst., 84: 1486-1491, 1992.
19. Poupon, M. F., Arvelo, F., Goguel, A. F., Bourgeois, Y., Jacrot, M., Hanania, N., Arriagada, R., and Le Chevalier, T. Response of small-cell lung cancer xenografts to chemotherapy: multidrug resistance and direct clinical correlates. J. Natl. Cancer Inst., 85: 2023-2029, 1993.
20. Tew, K. D. Glutathione-associated enzymes in anticancer drug resistance. Cancer Res., 54: 4313-4320, 1994.
21. Meijer, C., Mulder, N. H., Timmer-Bosscha, H., Zijlstra, J. G., and De Vries, E. G. E. Role of free radicals in an Adriamycin-resistant human small cell lung cancer cell line. Cancer Res., 47: 4613-4617, 1987.
22. Cole, S. P. C., Downes, H. F., Mirski, S. E. L., and Clements, D. J. Alterations in glutathione and glutathione-related enzymes in a multidrug resistant small cell lung cancer cell line. Mol. Pharmacol., 37: 192-197, 1990.
23. Campling, B. G., Baer, K. A., Lam, Y-M., Gerlach, J. H., Cole, S. P. C., and Mirski, S. E. L. Correlation of topoisomerase II levels and drug response in small cell lung cancer. Proc. Am. Soc. Cancer Res., 35: 453, 1994.
24. Giaccone, G., Gazdar, A. F., Beck. H., Zunino, F., and Capranico, G. Multidrug sensitivity phenotype of human lung cancer cells associated with topoisomerase II expression. Cancer Res., 52: 1666-1674, 1992.
25. Kasahara, K., Fujiwara, Y., Sugimoto, Y., Nishio, K., Tamura, T., Matsuda, T., and Saijo, N. Determinants of response to the DNA topoisomerase II inhibitors doxorubicin and etoposide in human lung cancer cell lines. J. Natl. Cancer Inst., 84: 113-118, 1992.