Pharmacokinetics and bioavailability of tacrolimus in rats with experimental renal dysfunction

Journal of Pharmacy and Pharmacology

Volumn 52, Issue 12, 2000, Pages 1467-1472

  Okabe, H ^a   Hashimoto, Y ^a   Inui, K I ^a  

^a KYOTO UNIVERSITY HOSPITAL   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

TACROLIMUS;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG METABOLISM; EXPERIMENTAL MODEL; KIDNEY DISEASE; KIDNEY FUNCTION; MALE; NONHUMAN; RAT;

ALANINE TRANSAMINASE; ANIMALS; AREA UNDER CURVE; ASPARTATE AMINOTRANSFERASES; BIOLOGICAL AVAILABILITY; BLOOD UREA NITROGEN; CISPLATIN; CREATININE; IMMUNOSUPPRESSIVE AGENTS; INFUSIONS, INTRAVENOUS; INTESTINAL ABSORPTION; KIDNEY FAILURE; MALE; METABOLIC CLEARANCE RATE; RATS; RATS, WISTAR; TACROLIMUS;

EID: 0034527650     PISSN: 00223573     EISSN: None     Source Type: Journal    
DOI: 10.1211/0022357001777676     Document Type: Article

References (21)

1. Influence of renal failure on the hepatic clearance of bufuralol in man
2. Pharmacokinetics and effects of propranolol in terminal uraemic patients and in patients undergoing regular dialysis treatment
3. Influence of renal disease on pharmacokinetics
4. Pharmacokinetics of d-propoxyphene in anephric patients
5. Effects of intestinal and hepatic metabolism on the bioavailability of tacrolimus in rats
6. The mechanism of action of cyclosporin A and FK506
7. Reduced hepatic uptake of propranolol in rats with acute renal failure
8. Increased availability of propranolol in rats with uranyl nitrate-induced acute renal failure
9. Intestinal absorption of drugs in rats with glycerol-induced acute renal failure
10. Altered S(-)-propranolol disposition in bilateral ureter-ligated rats
11. P-glycoprotein and drug therapy in organ transplantation
12. Pharmacokinetics of oral propranolol in chronic renal disease
13. Renal excretion of vancomycin in rats with acute renal failure
14. Hepatic extraction of tacrolimus in rats with experimental liver diseases
15. Influence of glycerol-induced acute renal failure of the pharmacokinetics of cyclosporin in rats
16. Effect of experimental renal failure on the disposition kinetics of 1-propranolol in rats
17. Pharmacokinetics of 1-propranolol during repetitive dosing in normal and uranyl nitrate-induced renal failure rats
18. Reduced extraction of 1-propranolol by perfused rat liver in the presence of uremic blood
19. Clinical pharmacokinetics of tacrolimus
20. Pharmacokinetics and pharmaco-dynamics of FK506 in pediatric patients receiving living-related donor liver transplantations
21. Identification of human CYP isoforms involved in the metabolism of propranolol enantiomers - N-desisopropylation is mediated mainly by CYP1A2