Intramyocardial injection of DNA encoding vascular endothelial growth factor in a myocardial infarction model

Journal of Thrombosis and Thrombolysis

Volumn 10, Issue 3, 2000, Pages 285-289

  Kloner, Robert A ^a   Dow, Joan ^a   Chung, Gene ^b   Kedes, Larry H ^b  

^a Good Samaritan Hospital   (United States)

^b UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

Author keywords

Angiogenesis; Gene therapy; Myocardial infarction; Vascular endothelial growth factor (VEGF)

Indexed keywords

DNA; VASCULOTROPIN;

ANGIOGENESIS; ANGIOMA; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; DOSE RESPONSE; GENE THERAPY; HEART INFARCTION; HEART MUSCLE; HEART MUSCLE BLOOD FLOW; HISTOPATHOLOGY; NONHUMAN; PRIORITY JOURNAL; RAT; TREATMENT FAILURE;

ANIMALS; CELL LINE; DISEASE MODELS, ANIMAL; ENDOTHELIAL GROWTH FACTORS; HEART VENTRICLES; HEMANGIOMA; INJECTIONS, INTRA-ARTERIAL; LYMPHOKINES; MYOCARDIAL INFARCTION; NEOVASCULARIZATION, PHYSIOLOGIC; RATS; RATS, SPRAGUE-DAWLEY; REGIONAL BLOOD FLOW; TRANSFECTION; VACCINES, DNA; VASCULAR ENDOTHELIAL GROWTH FACTOR A; VASCULAR ENDOTHELIAL GROWTH FACTORS; VENTRICULAR REMODELING;

EID: 0034526683     PISSN: 09295305     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1026507627097     Document Type: Article

References (14)

1. Angiogenic factors
2. Intracoronary gene transfer of fibroblast growth factor-5 increases blood flow and contractile function in an ischemic region of the heart
3. 165 as sole therapy for myocardial ischemia
4. Evaluation of the effects of intramyocardial injection of DNA expressing vascular endothelial growth factor (VEGF) in a myocardial infarction in the rat-angiogenesis and angioma formation
5. Left ventricular topographic alterations in the completely healed rat infarct caused by early and late coronary reperfusion
6. Angiogenic-induced enhancement of collateral blood flow to ischemic myocardium by vascular endothelial growth factors in dogs
7. Basic fibroblast growth factor improves myocardial function in chronically ischemic porcine hearts
8. Comparative effects of basic fibroblast growth factor and vascular endothelial growth factor on coronary collateral development and the arterial response to injury
9. Angiogenesis by gene therapy: A new horizon for myocardial revascularization
10. Induction of neoangiogenesis in ischemic myocardium by human growth factors: First clinical results of a new treatment of coronary heart disease
11. Salvage of infarct myocardium by angiogenic action of basic fibroblastic growth factor
12. Adenovirus-mediated gene transfer into infarcted myocardium: Feasibility, timing, and location of expression
13. Ischemic/reperfused myocardium can express recombinant protein following direct DNA or retroviral injection
14. Reduction in myocardial infarct size by basic fibroblastic growth factor after temporary coronary occlusion in a canine model