Improved in vivo antitumor efficacy and reduced systemic toxicity of carboxymethylpullulan-peptide-doxorubicin conjugates

Japanese Journal of Cancer Research

Volumn 91, Issue 12, 2000, Pages 1333-1338

  Nogusa, H ^a   Hamana, H ^a   Uchida, N ^a   Meakawa, R ^a   Yoshioka, T ^a  

^a SHIONOGI AND CO LTD   (Japan)

Author keywords

Carboxymethylpullulan; Doxorubicin; Enhanced permeability and retention; Polymeric drug

Indexed keywords

ANTIMETASTATIC AGENT; ANTINEOPLASTIC AGENT; DOXORUBICIN; DOXORUBICIN DERIVATIVE; DRUG CARRIER; DRUG VEHICLE; GLYCINE; HYDROXYL GROUP; LEUCINE; MALTOTRIOSE; N (2 HYDROXYPROPYL)METHACRYLAMIDE; PHENYLALANINE; PLASMA SUBSTITUTE; POLYMER; PULLULAN; SODIUM CHLORIDE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER SURVIVAL; CONTROLLED STUDY; DOSE RESPONSE; DRUG CONJUGATION; DRUG EFFICACY; DRUG MIXTURE; DRUG STRUCTURE; FEMALE; IN VIVO STUDY; LEUKEMIA; LUNG CARCINOMA; METASTASIS INHIBITION; MOUSE; NONHUMAN; PRIORITY JOURNAL; RETICULOSARCOMA; TOXICITY TESTING; TUMOR MODEL; TUMOR REGRESSION; WEIGHT REDUCTION;

EID: 0034526074     PISSN: 09105050     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1349-7006.2000.tb00922.x     Document Type: Article

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