Protein kinase C βI is implicated in the regulation of neuroblastoma cell growth and proliferation

Cell Growth and Differentiation

Volumn 11, Issue 12, 2000, Pages 641-648

  Svensson, K ^a   Zeidman, R ^a   Troller U ^a   Schultz, A ^a   Larsson, C ^a  

^a LUND UNIVERSITY   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; BROXURIDINE; CYCLIN A; GREEN FLUORESCENT PROTEIN; LY 379196; PACLITAXEL; PHORBOL ESTER; PROTEIN KINASE C; PROTEIN KINASE C INHIBITOR; VINCRISTINE;

ANIMAL CELL; ARTICLE; CELL GROWTH; CELL PROLIFERATION; CONTROLLED STUDY; ENZYME INHIBITION; GENETIC TRANSFECTION; MICROTUBULE; NEUROBLASTOMA CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN EXPRESSION;

ANTINEOPLASTIC AGENTS, PHYTOGENIC; BLOTTING, WESTERN; BROMODEOXYURIDINE; CELL DIFFERENTIATION; CELL DIVISION; CELL SURVIVAL; CYCLIN A; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME INHIBITORS; ISOENZYMES; MICROSCOPY, FLUORESCENCE; MODELS, BIOLOGICAL; NEUROBLASTOMA; PACLITAXEL; PLASMIDS; PROTEIN ISOFORMS; PROTEIN KINASE C; PROTEIN STRUCTURE, TERTIARY; TUMOR CELLS, CULTURED; VINCRISTINE;

ANIMALIA;

EID: 0034524218     PISSN: 10449523     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (28)

1. Intracellular signaling by hydrolysis of phospholipids and activation of protein kinase C
2. Regulation of protein kinase C
3. The extended protein kinase C family
4. Overexpression of protein kinase C-δ and -ε in NIH 3T3 cells induces opposite effects on growth, morphology, anchorage dependence, and tumorigenicity
5. Two closely related isoforms of protein kinase C produce reciprocal effects on the growth of rat fibroblasts
6. The roles of protein kinase C βI and βII in vascular smooth muscle cell proliferation
7. Phenotypic changes of human neuroblastoma cells in culture induced by 12-0-tetradecanoyl-phorbol-13-acetate
8. Protein kinase C remains functionally active during TPA induced neuronal differentiation of SH-SY5Y human neuroblastoma cells
9. PKCε, via its regulatory domain and independently of its catalytic domain, induces neurite-like processes in neuroblastoma cells
10. Novel and classical isoforms have different functions in proliferation, survival and differentiation of neuroblastoma cells
11. Anchoring proteins for protein kinase C: A means for isozyme selectivity
12. C2 region-derived peptides inhibit translocation and function of β protein kinase C in vivo
13. A protein kinase C translocation inhibitor as an isozyme-selective antagonist of cardiac function
14. An inhibitory fragment derived from protein kinase Cε prevents enhancement of nerve growth factor responses by ethanol and phorbol esters
15. Protein kinase C βII specifically binds to and is activated by F-actin
16. Mapping of a molecular determinant for protein kinase C βII isozyme function
17. Specific interaction of the PDZ domain protein PICK1 with the COOH terminus of protein kinase C-α
18. Coordination of an array of signaling proteins through homo- and heteromeric interactions between PDZ domains and target proteins
19. A multivalent PDZ-domain protein assembles signalling complexes in a G-protein-coupled cascade
20. Pharmacologic modulation of protein kinase C isozymes: The role of RACKs and subcellular localisation
21. Multiple pathways control protein kinase C phosphorylation
22. (S)-13-[(Dimethylamino)mehtyl]- 10,11,14,15-tetrahydro-4,9,16,21-dimetheno- 1H,13H-dibenzo[e,k]pyrrolo[3,4-h][1,4,13] oxadiazacyclohexadecene ione (LY333531) and related analogues: Isozyme selective inhibitos of protein kinase C β
23. Effects of protein kinase Cα overexpression on A7r5 smooth muscle cell proliferation and differentiation
24. Decreased PKC-α expression increases cellular proliferation, decreases differentiation, and enhances the transformed phenotype of CaCo-2 cells
25. 1 phase
26. Characterization of vascular endothelial growth factor's effect on the activation of protein kinase C, its isoforms, and endothelial cell growth
27. Overexpression of protein kinase C βII induces colonic hyperproliferation and increased sensitivity to colon carcinogenesis
28. Enzymatic rationale and preclinical support for a potent protein kinase C β inhibitor in cancer therapy