The molecular mechanism of dopamine-induced apoptosis: Identification and characterization of genes that mediate dopamine toxicity

Journal of Neural Transmission, Supplement

Volumn 60, Issue , 2000, Pages 59-76

  Barzilai, A ^a   Zilkha Falb, R ^a   Daily, D ^a   Stern, N ^a   Offen, D ^b   Ziv, I ^b   Melamed, E ^b   Shirvan, A ^b  

^a TEL AVIV UNIVERSITY   (Israel)

^b RABIN MEDICAL CENTER   (Israel)

Author keywords

[No Author keywords available]

Indexed keywords

ASCORBIC ACID; CHAPERONIN; DOPAMINE; DOPAMINE RECEPTOR; HEAT SHOCK PROTEIN 60; IRON; NEUROMELANIN; SEMAPHORIN 3A; T COMPLEX PROTEIN 1 DELTA INHIBITOR; UNCLASSIFIED DRUG;

AEROBIC METABOLISM; ANIMAL CELL; ANIMAL TISSUE; APOPTOSIS; CELL VIABILITY; CHICK EMBRYO; CONFERENCE PAPER; DOPAMINE RELEASE; DOPAMINERGIC NERVE CELL; EMBRYO; NEUROPROTECTION; NEUROTOXICITY; NEUROTRANSMITTER RELEASE; NEWBORN; NONHUMAN; PARKINSON DISEASE; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT;

ANIMALS; APOPTOSIS; CELLS, CULTURED; CHAPERONIN 60; CHAPERONINS; CHICK EMBRYO; DOPAMINE; GENE EXPRESSION REGULATION; GLYCOPROTEINS; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; MICE; NERVE TISSUE PROTEINS; NEURONS; OXIDATIVE STRESS; OXIDOREDUCTASES; PARKINSON DISEASE; PROTEINS; RATS; RNA, MESSENGER; SEMAPHORIN-3A; UP-REGULATION;

EID: 0034520369     PISSN: 03036995     EISSN: None     Source Type: Journal    
DOI: 10.1007/978-3-7091-6301-6_4     Document Type: Article

References (77)

1. Glutaredoxin homologue encoded by vaccinia virus is a virion-associated enzyme with thioltransferase and dehydroascorbate reductase activity
2. Apoptosis and autophagy in nigral neurons of patients with Parkinson's disease
3. Dopamine neurotoxicity: Inhibition of mitochondrial respiration
4. Mitochondrial respiratory failure in skeletal muscle from patient with Parkinson's disease and multiple system atrophy
5. Lesions of central norepinephrine terminals with 6-hydroxydopamine: Biochemistry and fine structure
6. Rapid ATP loss caused by methamphetamine in the mouse striatum: Relationship between energy impairment and dopaminergic neurotoxicity
7. Role of dopamine autoxidation, hydroxyl radical generation and calcium overload in underlying mechanisms involved in MPTP-induced parkinsonism
8. Oxidative stress in the nervous system
9. Parkinson's disease: A new link between monoamine oxidase and mitochondrial electron flow
10. Selective protection by hsp 70 against cytotoxic drug-, but not Fas-induced T-cell apoptosis
11. The involvement of p53 in dopamine induced apoptosis of cerebellar granule neurons and leukemic cells overexpressing p53
12. The oxidant stress hypothesis in Parkinson's disease. Evidence supporting it
13. Secreted chick semaphorins bind recombinant neuropilin with similar affinities but bind different subsets of neurons in situ
14. Pre- and postsynaptic neurotoxic effects of dopamine demonstrated by intrastriatal injection
15. Role of catechol autoxidation in the degeneration of dopamine neurons
16. Heat shock proteins protect cultured fibroblasts from the cytotxic effects of MPP+
17. Selective role of glutathione in protecting human neuronal cells from dopamine-induced apoptosis
18. Semaphorin III can induce death in sensory neurons
19. Increased heat shock protein 90 (hsp90) expression leads to increased apoptosis in the monoblastoid cell line U937 following induction with TNF-α and cycloheximide
20. The primary structure of pig liver thioltrasferase
21. Complete amino acid sequence of yeast thiol transferase (glutaredoxin)
22. A cytoplasmic chaperonin that catalyzes β-actin foleling
23. Molecular mechanisms for neurodegeneration: Synergism between reactive oxygen species, calcium and excitoxic amino acids
24. 1-Trechloromethyl-l,2,3,4-tetrahydro-b-carboline (TaClo) increases extracellular serotonin and stimulates hydroxyl radical production
25. The likeness of being: Phylogenetically conserved molecular mechanisms of growth cone guidance
26. Collapsin-induced growth cone collapse mediated by an intracellular protein related to UNC-33
27. 3H] dopamine: Impact of ascorbic acid and glutathione
28. Neuropilin is a receptor for the axonal chemorepellent semaphorin III
29. Distribution of semaphorin IV in adult human brain
30. The primary structure of Escherichia coli glutaredoxin. Distant homology with thioredoxins in a superfamily of small proteins with a redox-active cystine disulfide/cysteine dithiol
31. Glutaredoxin from rabbit bone marrow. Purification, characterization and amino acid sequence determined by tandem mass spectrometry
32. Ulterated aconitase activity but decreased complex I activity in substantia nigra pars compacta of patients with Parkinson's disease
33. Parkinsonism-inducing neurotoxin, N-methyl-4-phenyl-l,2,3,6-tetrahydropyridine: Uptake of the metabolite N-methyl-4-phenylpyridine by dopamine neurons explains selective toxicity
34. Oxidative stress as a cause of Parkinson's disease
35. The primary structure of calf thymus glutaredoxin. Homology with the corresponding Escherichia coli protein but elongation at ends and with an additional half-cysteine/cysteine pair
36. Growth cones and the cues that repel them
37. Neuropilin is a semaphorin III receptor
38. A 70 amino acid region within the semaphorin domain activates specific cellular response of semaphorin family members
39. A family of molecules related to collapsin in the embryonic chick nervous system
40. Dopamine induces apoptotic cell death of cathecolaninergic cell line derived from the central nervous system
41. Toxicity of dopamine to striatal neurons in vitro and potentiation of cell death by a mitochondrial inhibitor
42. Toxicity of 6-hydroxydopamine and dopamine for dopaminergic neurons in cell culture
43. Cloning and sequence analysis of a cDNA encoding rice glutaredoxin
44. Apoptosis in neurodegenerative disorders
45. Toxic and protective effects of L-DOPA on mesencephalic cell cultures
46. Methamphetamine-induced dopamine terminals alteration by dopamine D1 and D2 antagonists
47. Dopamine-induced programmed cell death in mouse thymocytes
48. Dopamine-induced apoptosis is inhibited in PC12 cells expressing Bcl-2
49. Purification from placenta, amino acid sequence, structure comparison and cDNA cloninig of human glutaredoxin
50. Abnormalities in electron transport chain in idiopathic Parkinson's disease
51. Chronic levodopa administration alters cerebral mitochondrial respiratory chain activity
52. Heat shock and apoptosis; The two defense systems of the organism may have overlapping molecular elements
53. BAX translocation is a critical event in neuronal apoptosis: Regulation by neuroprotectants, BCL-2, and caspases
54. +) and its analogs with rotenone/piericidin binding site of NADH dehydrogenase
55. Transition metals ferritin, gltathione, and ascorbic acid in parkinsonian brains
56. Catecholamine toxicity in cerebral cortex of dissociated cell cultur
57. Neuronal death caused by apoptosis in Parkinson disease
58. Presence of pre-apoptotic complex of pro-caspase-3, Hsp60 and Hsp10 in the mitochondrial fraction of Jurkat cells
59. Mitochondrial complex I deficiency in Parkinson's disease
60. Two waves of cyclin B and proliferating nuclear antigen expression during dopamine-triggered neuronal apoptosis
61. Semaphorins as mediators of apoptosis
62. Dopamine induced apoptosis in human neural cells: Inhibition by nucleic acid antisense to the dopamine transporter
63. +) in the neostriatum of the rat
64. The t-complex polypeptide 1 complex is a chaperonin for tubulin and actin in vivo
65. DOPA and dopamine cause cultured neuronal death in the presence of iron
66. A fluorescent double-labeling method to detect and confirm apoptotic nuclei in parkinson's disease
67. The molecular biology of axon guidance
68. A family of rat CRMP genes is differentially expressed in the neurvous system
69. Hsp60 accelerates the maturation of procaspase-3 by upstream activator proteases during apoptosis
70. TCP-1 complex is a molecular chaperone in tubulin biogenesis
71. The possible role of iron in the ethiology of Parkinson's disease
72. Iron melanin interaction and Parkinson's disease
73. Monoamines-induced apoptotic neuronal cell death
74. Dopamine induced apoptosis-like cell death in cultured chick sympathetic neurons-a possible novel pathogenetic mechanism in Parkinson's disease
75. The protooncogene bcl-2 inhibits cellular toxicity of dopamine: Possible implication for Parkinson's disease