Cardiovascular effects of ketanserin on normotensive rats in vivo and in vitro

General Pharmacology: The Vascular System

Volumn 35, Issue 2, 2000, Pages 95-105

  Orallo, Francisco ^a   Rosa, Elizabeth ^a   García Ferreiro, Tomás ^a   Campos Toimil, Manuel ^a   Cadavid, M Isabel ^a   Loza, M Isabel ^a  

^a UNIVERSITY OF SANTIAGO DE COMPOSTELA   (Spain)

Author keywords

1 adrenoceptor blocking; 5 HT2A blocking; Anaesthetized normotensive rats; Calcium antagonist activity; Ketanserin; Rat aorta; Rat atria

Indexed keywords

ALPHA 1 ADRENERGIC RECEPTOR; ANTIHYPERTENSIVE AGENT; CALCIUM ION; KETANSERIN; POTASSIUM ION; SEROTONIN 2A RECEPTOR;

ALPHA ADRENERGIC RECEPTOR BLOCKING; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD PRESSURE REGULATION; CALCIUM ANTAGONISM; CALCIUM TRANSPORT; CARDIOVASCULAR EFFECT; CHRONOTROPISM; CONCENTRATION RESPONSE; CONTROLLED STUDY; DOSE RESPONSE; DRUG ACTIVITY; DRUG MECHANISM; DRUG MEGADOSE; HEART ATRIUM CONTRACTION; HYPOTENSION; IN VITRO STUDY; IN VIVO STUDY; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; RECEPTOR BLOCKING; VASODILATATION;

ANIMALS; BLOOD PRESSURE; CALCIUM; DOSE-RESPONSE RELATIONSHIP, DRUG; HEART RATE; HEMODYNAMIC PROCESSES; KETANSERIN; MALE; NOREPINEPHRINE; RATS; RATS, SPRAGUE-DAWLEY; SEROTONIN; SEROTONIN ANTAGONISTS;

EID: 0034518518     PISSN: 03063623     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0306-3623(01)00099-4     Document Type: Article

References (38)

1. Some quantitative uses of drug antagonists
2. Differences in the acute and chronic antihypertensive mechanism of action of ketanserin in spontaneously hypertensive rats
3. Cardiovascular profile and hypotensive mechanism of ketanserin in the rabbit
4. Vascular serotonin receptors and blood pressure regulation
5. 2) receptor antagonist, does not lower blood pressure in the spontaneously hypertensive rat
6. Peripheral and central cardiovascular effects of ketanserin in conscious normotensive rats
7. An investigation of the effects of intravenous injection of the 5-hydroxytryptamine 2 receptor antagonists ketanserin and LY 53857 on blood pressure in anaesthetized spontaneously hypertensive rats
8. Mechanism of the hypotensive effect of ketanserin
9. Antihypertensive effects of ketanserin in the spontaneously hypertensive rat: Mode of action
10. Central sympathoinhibitory effects of ketanserin in the spontaneously hypertensive rat
11. Peripheral serotonergic mechanisms in cardiovascular regulation in the spontaneously hypertensive rat
12. 1-adrenoceptor antagonist, in anaesthetized rabbits
13. Characterization of the antihypertensive properties of ketanserin (R 41 468) in rats
14. 2A receptors in cardiovascular regulation in anaesthetized rats
15. Mechanism of ketanserin-induced sympatho-inhibition
16. Effects of ketanserin on the pacemaker activity of rabbit sinus node in vitro
17. 2 receptors
18. Ketanserin reduces a particular monoamine pool in peripheral tissues
19. 45Ca inducidas por noradrenalina y 5-HT en aorta de rata sin endotelio
20. Influence of alpha 1-adrenoceptor antagonism of ketanserin on the nature of its 5-HT2 receptor antagonism
21. Studies on the mechanism of action of the hypotensive effect of ketanserin
22. Characterization of the central sympathoinhibitory action of ketanserin
23. Evidence for an alpha-1 receptor-mediated central sympathoinhibitory action of ketanserin
24. Negative chronotropic action of ketanserin on isolated rat right atria and its mechanism analysis
25. Regulation of cytosolic calcium levels in vascular smooth muscle
26. Study of the in vivo and in vitro cardiovascular effects of a hydralazine-like vasodilator agent (HPS-10) in normontensive rats
27. Cardiovascular effects in the rat of ketanserin, a novel 5-hydroxytryptamine receptor blocking agent
28. 2) receptor blockade with ketanserin in the spontaneously hypertensive rat
29. Hypotensive actions of ketanserin in dogs: Involvement of a centrally mediated inhibition of sympathetic vascular tone
30. + channels?
31. 2 analysis I: Schild plot
32. 2-serotonergic antagonist ketanserin
33. 5-Hydroxytryptamine and vascular disease
34. 2 serotonergic receptors
35. Interaction between S2-serotonergic and alpha 1-adrenergic receptor activities at vascular sites
36. Cumulative dose-response curves: II. Technique for the making of dose-response curves in isolated organs and the evaluation of drug parameters
37. 5HT, alpha-adrenoceptors and blood pressure effects of ketanserin in essential hypertension and autonomic insufficiency
38. Ketanserin inhibits depolarization-activated outward potassium current in rat ventricular myocytes