Hexokinase 'binding sites' of normal and tumoral human brain mitochondria

Molecular and Cellular Biochemistry

Volumn 215, Issue 1-2, 2000, Pages 115-121

  Golestani, Abolfazl ^a   Nemat Gorgani, Mohsen ^a  

^a UNIVERSITY OF TEHRAN   (Iran)

Author keywords

Binding sites; Hexokinase type I; Monoclonal antibody; Normal and tumoral brain mitochondria; Porin

Indexed keywords

HEXOKINASE; MONOCLONAL ANTIBODY; PORIN;

AMINO TERMINAL SEQUENCE; ARTICLE; BINDING AFFINITY; BINDING SITE; BRAIN MITOCHONDRION; BRAIN TUMOR; CONTROLLED STUDY; ENZYME ASSAY; ENZYME BINDING; GLYCOLYSIS; HUMAN; HUMAN CELL; HUMAN TISSUE; MITOCHONDRIAL MEMBRANE; PROTEIN ANALYSIS; PROTEIN DEGRADATION; PROTEIN INTERACTION; RECEPTOR SOLUBILIZATION; REGULATORY MECHANISM; SOLUBILIZATION;

AMINO ACID SEQUENCE; ANIMALS; BINDING SITES; BRAIN; BRAIN NEOPLASMS; CATALYTIC DOMAIN; GLUCOSE-6-PHOSPHATE; HEXOKINASE; HUMANS; KINETICS; LIVER; MITOCHONDRIA; MODELS, BIOLOGICAL; MOLECULAR SEQUENCE DATA; PROTEIN BINDING; RATS; SEQUENCE HOMOLOGY, AMINO ACID; THIOCYANATES; TISSUE DISTRIBUTION;

EID: 0034516873     PISSN: 03008177     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1026562920315     Document Type: Article

References (49)

1. Pore protein and hexokinase-binding protein from the outer membrane of rat liver mitochondria are identical
2. Evidence for identity between the hexokinase-binding protein and the mitochondrial porin in the outer membrane of rat liver mitochondria
3. Homologous and heterologous interactions between hexokinase and mitochondrial porin: Evolutionary implications
4. Effect of macromolecules on the structure of the mitochondrial inter-membrane space and the regulation of hexokinase
5. Hexokinase receptor complex in Hepatoma mitochondria: Evidence from N, N′-Dicyclohexylcarbodiimide-labeling studies for the involvement of the pore-forming protein VDAC
6. An intact hydrophobic N-terminal sequence is critical for binding of rat hexokinase to mitochondria
7. Regulation of mitochondrial hexokinase in cultured HT29 human cancer cells. An ultrastructure and biochemical study
8. Targeting of hexokinase 1 to liver and hepatoma mitochondria
9. Coordinated regulation of cerebral glycolytic and oxidative metabolism, mediated by mitochondrially bound hexokinase dependent on intramitochondrially generated ATP
10. Complexes between kinases, mitochondrial porin and adenylate translocator in rat brain resemble the permeability transition pore
11. Subfractionation of the outer membrane of rat brain mitochondria: Evidence for the existence of a domain containing the porin-hexokinase complex
12. Mitochondrial hexokinase of rat hepatoma cells in culture: Solubilization and kinetic properties
13. Mitochondrial hexokinase in brain of various species: Differences in sensitivity to solubilization by glucose 6-phosphate
14. Effect of neutral salts on the interaction of rat brain hexokinase with the outer mitochondrial membrane
15. A high-yield preparation method for isolation of rat liver mitochondria
16. New method for quantitative determination of serum proteins separated by paper electrophoresis
17. Rapid purification of mitochondrial hexokinase from rat brain by a single affinity chromatography step on Affi-Gel Blue
18. Purification and properties of rat brain hexokinase
19. Cleavage of structural proteins during the assembly of the head of bacteriophage T4
20. Rat brain hexokinase: Further studies on the specificity of the hexose and hexose 6-phosphate binding sites
21. A practical curve-fitting microcomputer program for the analysis of enzyme kinetics data on IBM-PC compatible computers
22. Tetrameric structure of mitochondrially bound rat brain hexokinase: A crosslinking study
23. Disposition of mitochondrially bound hexokinase at the membrane surface, deduced from reactivity with monoclonal antibodies recognizing epitopes of defined location
24. The nervous system
25. Intracellular localization and properties of particulate hexokinase in Novikoff ascites tumor
26. Purification and characterization of a bindable form of mitochondrial bound hexokinase from the highly glycolytic AS-30D hepatoma cell line
27. Hexokinases
28. Rat brain hexokinase: The hydrophobic N-terminus of the mitochondrially bound enzyme is inserted in the lipid bilayer
29. Aberrant glycolytic metabolism of cancer cells: A remarkable coordination of genetic, transcriptional, post-translational, and mutational events that lead to a critical role of type II hexokinase
30. Modulation of glycolysis in neuroepithelial tumors
31. Glycolytic profile in normal brain tissue and gliomas determined by a micro-method analysis
32. High glycolysis in gliomas despite low hexokinase transcription and activity correlated to chromosome 10 loss
33. Energy metabolism of tumor cells. Requirement for a form of hexokinase with a propensity for mitochondrial binding
34. Microcompartmentation of energy metabolism at the outer mitochondrial membrane: Role in diabetes mellitus and other diseases
35. Functional significance of mitochondrial bound hexokinase in tumor cell metabolism: Evidence for preferential phosphorylation of glucose by intramitochondrially generated ATP
36. Regulation of mammalian hexokinase activity
37. Hexokinase of rat brain mitochondria: Relative importance of adenylate kinase and oxidation phosphorylation as source of substrate ATP, and interaction with intramitochondrial compartments of ATP and ADP
38. Mitochondria-bound hexokinase as target for therapy of malignant gliomas
39. Maximum activities of key enzymes of glycolysis, glutaminolysis, pentose phosphate pathway and tricarboxylic acid cycle in normal, neoplastic and suppressed cells
40. Gliomas are driven by glycolysis: Putative roles of hexokinase, oxidative phosphorylation and mitochondrial ultrastructure
41. High Km glucose-phosphorylating (glucokinase) activities in a range of tumor cell lines and inhibition of rates of tumor growth by the specific enzyme inhibitor mannoheptulose
42. Neoplastic diseases of the brain
43. The influence of specific phospholipids on the interaction of hexokinase with the outer mitochondrial membrane
44. High aerobic glycolysis of rat hepatoma cells in culture: Role of mitochondrial hexokinase
45. Functional organization of mammalian hexokinases: Characterization of chimeric hexokinases constructed from the N- and C-terminal domains of the rat type-I and type-II isozymes
46. Brain hexokinase: A proposed relation between soluble-particulate distribution and activity in vivo
47. Rat brain hexokinase: A kinetic comparison of soluble and particulate forms
48. Mitochondrial hexokinase: Release, rebinding, and location
49. Monoclonal antibodies against rat brain hexokinase